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Protein Alignment htl and erbb4

DIOPT Version :10

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_031748752.1	Gene:	erbb4 / 100493234	XenbaseID:	XB-GENE-877077	Length:	1300	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	194/768 - (25%)
Similarity:	299/768 - (38%)	Gaps:	202/768 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PAITNNANQSSTSSADLDDGAADD--------DDNKADLPVNVSSKPYWR----NPKKMSF---- 111
            |.:.:.....|..||...|.:..|        :.|...|...:...||..    .|:|::.
Frog   332 PKVCDGIGTGSLQSAQTVDSSNIDKFINCTKINGNLHFLVTGIDGDPYHNIAALEPQKLNIFFTV 396

  Fly   112 --------LQTRP---------------------SG-SLLTLNCHAL-------------GN--- 130
                    :|:.|                     || |||.|...:|             ||
Frog   397 REITGFLNIQSWPRNMTDLSVFSNLVNIGGRVLYSGISLLILKQQSLNSLQFQSLKEISAGNVYI 461

  Fly   131 -PEPNITWYRNGTVDWTRGYGSLKR--NRWTLTMEDLVPGDC---GNYTCKVCNSLGCIRHDTQV 189
             ...|:.:|.  ||:||    ||.|  |:.|...|:..|.:|   |.....:|::.||.......
Frog   462 TDNRNLCYYH--TVNWT----SLFRTSNQRTTIRENKKPENCTAEGMVCDPLCSNAGCWGPGANQ 520

  Fly   190 IVSDRVNHKPILMTGPLNL-----TLVVNSTGSMHCKYLSDLTSKKAWIFVPCHG-----MTNCS 244
            .:|.|...:........||     ...||  ||: |........|.....|.|:|     .|.||
Frog   521 CLSCRYFSRGKSCVRSCNLYKGESREFVN--GSV-CVMCDSQCEKMEDSIVTCYGPGPDHCTKCS 582

  Fly   245 NNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTA----YLRVVRSLHVLEAGVASGS- 304
            |.:          |..|          |||....|...:.:    |....:..|........|.
Frog   583 NFK----------DGPN----------CVEKCPEGLQGANSFIFKYADEDKECHPCHPNCTDGCR 627

  Fly   305 ----------LHSTSFVYIFVFGGL-IFIFMTTLFVFYAIRK-MKHEKVLKQRIETVHQWTKKVI 357
                      :..|..:...|.||| |.:.|...|..|..|| :|.::.|::.:||
Frog   628 GPRLKDCIGIIDRTPLIAASVIGGLFIIVIMALTFAVYIRRKSIKKKRALRRFLET--------- 683

  Fly   358 IFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATL 422
                           .::.|:.          .:|..|   |:.:..:....||.|..:     |
Frog   684 ---------------ELVEPLT----------PSGTAP---NQAQLRILKETELKRIKI-----L 715

  Fly   423 GEGAFGRVVM------AEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS 481
            |.||||.|..      .|.....||:|::.|.......|..:.|..:|..:. |.:::.||| .|
Frog   716 GSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANAEFMDEALIMASMD-HPHLVRLLG-VS 778

  Fly   482 QNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDY 546
            .:..:.::.:..|||.|.|::::::      |...||.             |:.:..|||:||.|
Frog   779 LSPTIQLVTQLMPHGCLLDYVHEHK------DNIGSQL-------------LLNWCVQIAKGMMY 824

  Fly   547 LASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD 611
            |..||.:|||||||||||.....:||.||||||.::..:.......|::||||||.|.:..:.:.
Frog   825 LEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFT 889

  Fly   612 SKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNAD 676
            .:|||||||:.:||:||:|.:||..| ...|:...|..|:|:.:|..|::::|::|.:||..:||
Frog   890 HQSDVWSYGVTVWELMTFGGKPYDGI-PTREIPDLLEKGERLPQPPVCTIDVYMVMVKCWMIDAD 953

  Fly   677 DRPPFTEIVEYMDKLLQTKEDYLDVDIANLDTPPSTSD--------EEEDETD 721
            .||.|.|:.....::.:..:.||.:...:....||.:|        :|||..|
Frog   954 SRPKFKELAAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLGD 1006

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.