Protein Alignment htl and tec

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_031751261.1
• Gene: tec / 100491653
• XenbaseID: XB-GENE-6076361
• Length: 648
• Species: Xenopus tropicalis
• Alignment Length: 758
• Identity: 168/758 - (22%)
• Similarity: 294/758 - (38%)
• Gaps: 209/758 - (27%)

  Fly    26 LLLSIWQPAVQVEGRRQMANSQEMIKDHLGARSQNKTPAITNNANQSSTSSADLDDGAADDDDNK 90
            |:.:.|:...|    |...||..::::.|..|||.|                            |
 Frog     7 LMFNGWKTNEQ----RVEMNSDIILEESLIKRSQQK----------------------------K 39

  Fly    91 ADLPVNVSSKPYWRNPKKMSFLQTRP-------SGSLLTLNC-HALGNPEPNITW---------Y 138
            ...|:|...:.:.....::::.:.||       |..:..:.| ..:.|...||..         |
 Frog    40 RTSPLNYKERVFVLTKSRLTYYEGRPEKKNKKGSVDITKVKCVEFVKNGSENIPCQYKYAFQIVY 104

  Fly   139 RNGTV-----------DWTRGY-GSLKRNRWTLT-----------------MEDLVPGDCGNYTC 174
            .:.|:           .|.:.. ..:|.|.:.::                 .|.|.||      |
 Frog   105 ESNTLYVFAPTAESRFKWVKLIKEEVKNNSFIMSKYHPQFWADGVYQCCRQTEKLAPG------C 163

  Fly   175 KVCNSLGCIRHDTQVIVSDRVNHKP------------------ILM-----TGPLNLTLVVNSTG 216
            :..|..|.|.........|.:..:|                  |.|     ..|.:|.||   ||
 Frog   164 EEYNLFGDITKKPLPPTPDAIRARPPPPRPPDPEPEDNGEETVIAMFDFHPVEPHDLRLV---TG 225

  Fly   217 SMHCKYLSDLTSKKAWI---------FVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTC 272
            ..:  ::.:......|.         ::|.:.:|            :.:||    .:.|..||
 Frog   226 EEY--FVLEKKDAHWWKARNTYGQQGYIPSNYVT------------EKKLD----NLYQYEWY-- 270

  Fly   273 VESNSLGQSNSTAYLR--------VVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFV 329
              |.::.:|.:...|:        :||:..  :||:.:.||::.       :||    ..:|...
 Frog   271 --SRNMNRSKAEQLLKSEDKEGGFIVRNSS--QAGLYTVSLYTK-------YGG----EGSTCIR 320

  Fly   330 FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNE 394
            .|.|::.::.|......:.|.....::|.:...   :::|.:..:..||....|...|.
 Frog   321 HYHIKETQYPKKYYLAEKHVFNTIPEMIEYHKH---NAAGLVTRLRYPVCSKNKSAPTT------ 376

  Fly   395 PAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-VAVKMVKEGHTDDDIASLV 458
             |.|: |:     .||:..|.|.....||.|.||.|.:.:..... ||:|.::||...::  ..:
 Frog   377 -AGFS-YD-----KWEINPSELTFMKELGSGLFGVVRLGKWRAQYKVAIKAIREGAMSEE--DFI 432

  Fly   459 REMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFL-YKNRPFGRDQDRDSSQPPPS 522
            .|.:||..: .|:.::.|.|.|:|..|:|::.|:..||.|.::| .::..|..|
 Frog   433 EEAKVMMKL-THLKLVQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQFSPD----------- 485

  Fly   523 PPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY 587
                     .|:.....:...|.||.....|||||||||.||:|..|:|::|||:.|.:.. |.|
 Frog   486 ---------ILLSMCQDVCEAMSYLEQNNFIHRDLAARNCLVNDAGVVKVSDFGMTRYVLD-DQY 540

  Fly   588 RKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAE--ELYTYLMSG 650
            ..:...:.|:||..||......:.|||||||:|:|:||:.|.|:.|:.:..:.|  |:.|   .|
 Frog   541 TSSCGAKFPVKWSPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGKMPFESYSNVEVVEMVT---RG 602

  Fly   651 QRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQ 693
            :|:.:|...:..||.:|..|||...:.||.|.::::.:..:|:
 Frog   603 ERLYRPKLATKIIYSVMVACWHEKPEGRPKFFDLMKQIGLILE 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	20/135 (15%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	2/12 (17%)
		Ig strand E	157..161	CDD:409353	0/20 (0%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	0/2 (0%)
		Ig	200..289	CDD:472250	19/110 (17%)
		Ig strand B	216..220	CDD:409353	1/3 (33%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	1/3 (33%)
		Ig strand F	269..274	CDD:409353	2/4 (50%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	90/291 (31%)
tec	XP_031751261.1	PH_Btk	27..168	CDD:269944	25/174 (14%)
		SH3_Tec	204..259	CDD:212838	11/71 (15%)
		SH2_Tec_Itk	262..368	CDD:198259	24/129 (19%)
		PTKc_Tec_Rlk	386..645	CDD:270685	88/285 (31%)