Protein Alignment htl and epha8

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_031758381.1
• Gene: epha8 / 100487286
• XenbaseID: XB-GENE-5915618
• Length: 979
• Species: Xenopus tropicalis
• Alignment Length: 663
• Identity: 164/663 - (24%)
• Similarity: 262/663 - (39%)
• Gaps: 185/663 - (27%)

  Fly   116 PSGSLLTLNCHALGNPEPNITWYRNGT---VDWTRGYGS-----------LKRNRWTLTMEDLVP 166
            |||            || |:....|||   :|||....|           .:|..|
 Frog   323 PSG------------PE-NLISSVNGTSVSLDWTPPLDSGGRRDVTYNVICRRCAW--------- 365

  Fly   167 GDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHCKYLSDLTSKKA 231
             |.|.  |:.|.  |.:|:..|.:...|.:.....:...:|.|..|.:|..     :||. |.:.
 Frog   366 -DAGQ--CEPCG--GGVRYTPQQMGLARTSLTVANLQAHMNYTFWVEATNG-----VSDF-SLEP 419

  Fly   232 WIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWYTCV--------ESNSLGQSNSTAYLR 288
            .:|...:..||.:....::|          :| .|:.|.|.:        :.|.:.......|..
 Frog   420 RMFSSVNITTNQAAPSQVLA----------IR-HQKAWQTSISLLWPEPEQPNGVILEYEIKYYE 473

  Fly   289 VVRSLH---VLEA----GVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIR------------ 334
            ..:.:|   .|.|    .:.||....|.:|                   :.:|
 Frog   474 KGQEMHSYSTLRAKETRAIVSGLKPGTHYV-------------------FQVRARTSAGCGRFSP 519

  Fly   335 --KMKHEKVLKQRIET-VHQW-----------TKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQR 385
              :::..|.:..|..| ...|           ...|:|.|....|.|....|:       .:|:
 Frog   520 TVEVETSKAMALRYNTRTIVWICLILITGLVILLSVLICKKRHCGYSKAFQDS-------DEKK- 576

  Fly   386 TTVLQNGN----------EPAPFNEYEFPL----DSNWELPRSHLVLGATLGEGAFGRVVMAEV- 435
               ||||:          :|   :.||.|.    |...|:..|.:.:...:|.|.||.|....:
 Frog   577 ---LQNGHITLAASKLYVDP---HTYEDPCQAVRDFAREIEASRIRIEKIIGSGEFGEVCYGRLK 635

  Fly   436 ----NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG 496
                ....||:|.:|.|:::......:.|..:|.... |.|||.|.|..:::....::.||..:|
 Frog   636 VPGKREIPVAIKTLKAGYSEKQRRDFLSEASIMAQFD-HPNIIRLEGVVTRSKLTMIVTEYMENG 699

  Fly   497 NLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARN 561
            :|..||         :.||..       .::|   .|:.....|:.||.||:....|||||||||
 Frog   700 SLDSFL---------KSRDGQ-------FNII---QLVGMLRGISAGMKYLSDLGYIHRDLAARN 745

  Fly   562 VLVSDDYVLKIADFGLARDIQ-STDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE 625
            :||:::.|.|::||||:|.:: ..|.....|.|::||:|.|||::..:.:.|.|||||:||::||
 Frog   746 ILVNNNMVCKVSDFGLSRILEDDPDAAYTTTGGKIPIRWTAPEAITYRKFSSASDVWSFGIVMWE 810

  Fly   626 IMTYGQQPY------PTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEI 684
            ::.||::||      ..|.|.||       |.|:..|..|...::.||..||..:.::||.|:.|
 Frog   811 VLAYGERPYWNMTNRDVINSVEE-------GYRLPAPMGCPAALHQLMLDCWQRDRNERPRFSLI 868

  Fly   685 VEYMDKLLQTKED 697
            |..:|..|:..|:
 Frog   869 VSVLDNFLRNPEN 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	22/88 (25%)
		Ig strand B	121..125	CDD:409353	0/3 (0%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	1/3 (33%)
		Ig strand F	171..176	CDD:409353	1/4 (25%)
		Ig strand G	184..187	CDD:409353	1/2 (50%)
		Ig	200..289	CDD:472250	17/96 (18%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	0/3 (0%)
		Ig strand E	255..259	CDD:409353	0/3 (0%)
		Ig strand F	269..274	CDD:409353	2/12 (17%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	96/303 (32%)
epha8	XP_031758381.1	EphR_LBD	25..197	CDD:470656
		FN3	<305..>528	CDD:442628	48/267 (18%)
		FN3	434..525	CDD:238020	15/120 (13%)
		EphA2_TM	541..612	CDD:464211	17/84 (20%)
		Protein Kinases, catalytic domain	610..876	CDD:473864	93/292 (32%)
		SAM_EPH-A8	905..969	CDD:188949