Protein Alignment htl and epha4

DIOPT Version :10

• Sequence 1: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_012825631.1
• Gene: epha4 / 100216124
• XenbaseID: XB-GENE-1015803
• Length: 986
• Species: Xenopus tropicalis
• Alignment Length: 737
• Identity: 186/737 - (25%)
• Similarity: 286/737 - (38%)
• Gaps: 200/737 - (27%)

  Fly    60 NKTPAITNNANQSSTSSADLDDGAADDDDNKADLP--------------VNVSS-KPYWRNPKKM 109
            :|.|..:....:.|| |...|.|....|.:.|.:|              ||.:| ...|..|:..
 Frog   291 SKCPPHSYALREGST-SCTCDRGYFRADTDPASMPCTRPPSAPQNLISNVNETSVNLEWSPPQNS 354

  Fly   110 SFLQTRPS----------GSLLTLNCHALG-----NPEPNITWYRNGTVDWTRGYGSLKRNRWTL 159
            .   .||.          ||.|| .|...|     :|:.|                .||..:.::
 Frog   355 G---GRPDVTYNLVCKRCGSDLT-RCRPCGSGVHYSPQQN----------------GLKTTKVSI 399

  Fly   160 TMEDLVPGDCGNYTCKVCNSLGCIR----HDTQVIVSDRVNHKPILMTGPLNLTLVVNSTGSMHC 220
            |  ||....  |||.:|....|..:    .|..|.|:...|     ...|..:|.:.....:.|.
 Frog   400 T--DLQAHT--NYTFEVWAINGVSKQNPGQDQAVSVTVTTN-----QAAPSTVTQIQPKEITRHS 455

  Fly   221 KYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAE------DKDQLDFVNVRMEQEGWYTCVESNS-- 277
            ..|:....::|               ..:|.|      :|||         .|..|..|::.|
 Frog   456 VSLTWPEPERA---------------NGVILEYEVKYYEKDQ---------NERSYRIVKTASRS 496

  Fly   278 ---LGQSNSTAYLRVVRSLHVLEAGVASGSLH---------------STSFVYIFVFGGLIFIFM 324
               .|.:..|||:..||:......|..||...               |.:.:.:.|.|.::.:.:
 Frog   497 ADIKGLNPLTAYVFHVRARTAAGYGEFSGPFEFTTNTVPSPMIGEGASPTVLLVSVAGSIVLVVI 561

  Fly   325 TTLFVFYAIRKMKHEKVLKQRIETVH--QWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTT 387
            .......:.|:.|:.|..::..|..|  |..|..:
 Frog   562 LIAAFVISRRRSKYSKAKQEADEEKHLNQGVKTYV------------------------------ 596

  Fly   388 VLQNGNEPAPFNEYEFP----LDSNWELPRSHLVLGATLGEGAFGRVVMAEV-----NNAIVAVK 443
                    .||. ||.|    .:...|:..|.:.:...:|.|.||.|....:     ....||:|
 Frog   597 --------DPFT-YEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREIYVAIK 652

  Fly   444 MVKEGHTDDDIASLVREMEVMKIIGR--HINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR 506
            .:|.|:||......:.|..:|   |:  |.|||:|.|..::..|:.:|.||..:|:|..||.||.
 Frog   653 TLKAGYTDKQRRDFLSEASIM---GQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKND 714

  Fly   507 PFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLK 571
              ||                 .|...|:.....|..||.||:....:||||||||:||:.:.|.|
 Frog   715 --GR-----------------FTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCK 760

  Fly   572 IADFGLARDIQSTDYYRKNT-NGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYP 635
            ::|||::|.::........| .|::||:|.|||::..:.:.|.||||||||::||:|:||::||
 Frog   761 VSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPY- 824

  Fly   636 TIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQT----KE 696
            ..||.:::...:..|.|:..|..|.:.::.||..||.....|||.|.:||..:|||::.    |.
 Frog   825 WDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVSMLDKLIRNPNSLKR 889

  Fly   697 DYLD----VDIANLDTPPSTSD 714
            ..||    .:.|.||  ||:.:
 Frog   890 TGLDNSSRTNTALLD--PSSPE 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	101..191	CDD:472250	24/108 (22%)
		Ig strand B	121..125	CDD:409353	2/3 (67%)
		Ig strand C	134..138	CDD:409353	1/3 (33%)
		Ig strand E	157..161	CDD:409353	0/3 (0%)
		Ig strand F	171..176	CDD:409353	3/4 (75%)
		Ig strand G	184..187	CDD:409353	0/6 (0%)
		Ig	200..289	CDD:472250	18/99 (18%)
		Ig strand B	216..220	CDD:409353	0/3 (0%)
		Ig strand C	229..233	CDD:409353	1/3 (33%)
		Ig strand E	255..259	CDD:409353	2/3 (67%)
		Ig strand F	269..274	CDD:409353	1/4 (25%)
		Ig strand G	282..285	CDD:409353	0/2 (0%)
		Protein Kinases, catalytic domain	404..692	CDD:473864	101/299 (34%)
epha4	XP_012825631.1	EphR_LBD_A4	30..203	CDD:198450
		FN3	329..435	CDD:238020	28/129 (22%)
		FN3	440..531	CDD:238020	23/114 (20%)
		EphA2_TM	550..617	CDD:464211	15/105 (14%)
		PTKc_EphR_A	615..881	CDD:270651	99/288 (34%)
		SAM_EPH-A4	911..981	CDD:188944