DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and fgfr3

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_012812743.1	Gene:	fgfr3 / 100196923	XenbaseID:	XB-GENE-479255	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	675	Identity:	278/675 - (41%)
Similarity:	383/675 - (56%)	Gaps:	65/675 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SSADLDDGAADDDDNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNITWY 138
            ||.|.:|   |||:...|     ...|.|..|:|| ..|...|:.:.:...|.|.|||.|.|.|.
Frog   149 SSGDDED---DDDEETED-----REPPRWTQPEKMDKKLTAVPAANTIRFRCPAAGNPTPTIHWL 205

  Fly   139 RNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNHKPI 200
            :||..   :...|...|:..:|:|.||.:||.|.|||||.|.|..|.||...|:.|.:|.:|:||
Frog   206 KNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDKGNYTCVVENKYGSIRQTYQLDVLERSSHRPI 270

  Fly   201 LMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKD--------- 255
            |..| |.|.|:|:.|....|||..||......|       :.:...|.|....|.|
Frog   271 LQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQW-------LKHVEVNGSKYGPDGDPYVTVLQSF 328

  Fly   256 --------QLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVR--SLHVLEAGVASGSLHSTSF 310
                    .|...||....||.|.|..:|.:|.:.::.:|.:.:  |...:|....:.|..:|..
Frog   329 TNGTEVDTTLSLKNVTETHEGQYVCRANNFIGVAEASFWLHIYKPASAEPVEKPTTTSSSSTTVL 393

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMI 375
            :.:.|..|  ||.:..:||.|.: |:..:|.:.  ...||: ..|..:.:.:...:|:.||::.
Frog   394 IVVSVITG--FILLVIIFVTYRV-KVPSKKAMS--APPVHK-VSKFPLKRQQVSLESNSSMNSN- 451

  Fly   376 MPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEV----- 435
            .|:|||....::   :|...|..:|...|||..|||.|:.|.||..||||.||:|||||.
Frog   452 TPLVRITHLSSS---DGTMLANVSELGLPLDPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEK 513

  Fly   436 ---NNAI-VAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG 496
               |..: |||||:|:..||.|::.||.|||:||:||:|.|||||||.|:|:|||||:||||..|
Frog   514 ERPNKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKG 578

  Fly   497 NLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARN 561
            ||:::|...||.|.|...|:.:    .||..:|.|||:..|:|:||||:||||::||||||||||
Frog   579 NLREYLKARRPPGMDYSFDTCK----IPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARN 639

  Fly   562 VLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEI 626
            |||:||.|:|||||||||||.:.|||:|.||||||:||||||:|.::.|..:|||||||:||||.
Frog   640 VLVTDDNVMKIADFGLARDIHNIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWET 704

  Fly   627 MTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL 691
            .|.|..|||.| ..|||:..|..|.||:|||.|:..:|::||:|||.....||.|.::||.:|::
Frog   705 FTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRV 768

  Fly   692 L--QTKEDYLDVDIANLDTPPSTSD 714
            |  .:.::|||:.:......|:..|
Frog   769 LTVTSTDEYLDLSVPFEQYSPACQD 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	32/81 (40%)
		IG_like	113..191	CDD:214653	31/80 (39%)
		IG_like	205..289	CDD:214653	25/100 (25%)
		PKc_like	404..692	CDD:304357	169/296 (57%)
		STYKc	416..688	CDD:214568	161/280 (58%)
fgfr3	XP_012812743.1	IGc2	74..129	CDD:197706
		Ig2_FGFR	177..261	CDD:143265	32/83 (39%)
		Ig3_FGFR	284..371	CDD:319280	21/93 (23%)
		PTKc_FGFR3	476..809	CDD:173652	175/323 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55437
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1519
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9491
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.010