DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment htl and styk1

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001123790.1	Gene:	styk1 / 100170540	XenbaseID:	XB-GENE-979179	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	425	Identity:	110/425 - (25%)
Similarity:	185/425 - (43%)	Gaps:	66/425 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 STAYLRVVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIE 347
            ||..|.:||:..           :....|.:|:.|..:.:....|::.|..||...:   .||.:
Frog    18 STDQLCIVRTQE-----------YEVIVVPVFLIGVSVILLAIILWLRYRPRKPDED---DQRQD 68

  Fly   348 TVHQWTKKVIIFKPEGGG-DSSGSMDTMIM-PVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWE 410
            ...         ||..|. :.:.|::.:.: .|:|.:......|                    |
Frog    69 EQR---------KPSAGYINHAISLEELTLDQVLRTKDPSLQAL--------------------E 104

  Fly   411 LPRSHLVLGATL-GEGAFGRVVMAEVN------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIG 468
            :||..:.....| |||.||.:...::|      ...|.:|.::......:|...::.:.....:|
Frog   105 IPRGRIRQPLQLAGEGRFGPIYRTKLNGPEDGKEKDVIIKRLRNSCGAQEIRDFLQRVAFQGWLG 169

  Fly   469 RHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD-QDRDSSQPPPSPPAHVITEKD 532
            :|.||:.|||||....|..:::|....|:|..||:..|   || ...|..       .:.:||..
Frog   170 QHPNIVELLGCCPNEKPFCMVLENIEPGSLLHFLWDCR---RDVMSMDGI-------LYDLTECQ 224

  Fly   533 LIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPI 597
            :...|.|:...:.:|..|:..|.||||||:|:..:...|:...|.|.:::.|..:......  |:
Frog   225 VYTIALQVLSALGFLHQRKLFHGDLAARNILIHRNLTAKLTGLGGACEMRQTGTFPSRRPA--PL 287

  Fly   598 KWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMN 662
            ||||||.|......:||||||:||||:|::|.|..|||.| ...::..:|..|..|::|..|...
Frog   288 KWMAPERLLRLPISAKSDVWSFGILLYEMITLGAPPYPEI-PPNDILQHLQRGNIMKRPPTCKPA 351

  Fly   663 IYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED 697
            :|.:|:.||.:.|.:||...|:.:.::...:...|
Frog   352 MYNVMKICWLWKAPERPSLPELRKRLESAKKASND 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845
		IG_like	113..191	CDD:214653
		IG_like	205..289	CDD:214653	3/5 (60%)
		PKc_like	404..692	CDD:304357	88/295 (30%)
		STYKc	416..688	CDD:214568	85/279 (30%)
styk1	NP_001123790.1	PTKc	118..378	CDD:270623	84/272 (31%)
styk1	NP_001123790.1	STYKc	118..377	CDD:214568	84/271 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910