DRSC/TRiP Functional Genomics Resources

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Protein Alignment htl and btk

DIOPT Version :10

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001123732.1 Gene:btk / 100170477 XenbaseID:XB-GENE-6451230 Length:649 Species:Xenopus tropicalis


Alignment Length:628 Identity:146/628 - (23%)
Similarity:240/628 - (38%) Gaps:195/628 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 LNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTL-------TMEDLVPGDCGNYTCKVCNSL 180
            :.|..|||        .||.:...|   |.:|:|..|       :.:.|.|..|.:.        
 Frog   163 MGCQPLGN--------ANGFIRTER---SQRRSRKPLPPPPPQESQKPLPPTPCLSL-------- 208

  Fly   181 GCIRHDTQVIVSDRVNHKPILMTG--PLN-----------LTLVVNSTGSMHCKYLSDLTSKKAW 232
                            ||.:.|..  |||           ..|:...||:             .|
 Frog   209 ----------------HKVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGN-------------PW 244

  Fly   233 I----------FVP-----------------CHGMTNCSNNRSIIAEDKDQLDFVNVRMEQEGWY 270
            :          ::|                 ...||.....:.:.||||            ||.:
 Frog   245 LRARDKNGLEGYIPGNYVTEAQDPLEIYEWYSKNMTRSQAEKLLRAEDK------------EGGF 297

  Fly   271 TCVESNSLGQSNSTAYLR-----VVRSLHVLEAGVASGSLHSTSFVYIFVFGGLIFIFMTTLFVF 330
            ...:|:..|:...:.|.:     ::|...|.|   |.|:                        .:
 Frog   298 IVRDSSKAGKYTVSVYAKSSGEGIIRHYVVCE---APGN------------------------QY 335

  Fly   331 YAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEP 395
            |...|..:..:  ..:.|.||             .:::|.:..:..||..::|...:....|.  
 Frog   336 YLAEKHLYSSI--PELITYHQ-------------HNAAGLISRLKYPVCSLRKTAPSTAGLGY-- 383

  Fly   396 APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNA-IVAVKMVKEGHTDDDIASLVR 459
                       .:||:....|.....||.|.||.|...:.... .||:||:|||...:|  ..:.
 Frog   384 -----------GSWEIDPKDLTFLKELGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSED--EFIE 435

  Fly   460 EMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPP 524
            |.:.|..:. |.|::.|.|.|::..|:::|.|:..:|.|.::|...|  ||              
 Frog   436 EAKCMMKLS-HQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLR--GR-------------- 483

  Fly   525 AHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRK 589
               :::.||:.....:...|.||.|::.:||||||||.||:.|.::|::||||:|.:.. |.|..
 Frog   484 ---VSQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVLD-DEYTS 544

  Fly   590 NTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRME 654
            :...:.|::|.:||.|....:.|||||||:|:|:||:.|.|:.||....: .|:...:..|.|:.
 Frog   545 SLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLGRMPYDRFTN-NEIVEQITRGVRLY 608

  Fly   655 KPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLLQTKED 697
            :|...:..:|.:|..||...|||||.|..:   .:.:|:..||
 Frog   609 RPQNATDRVYSIMVSCWAEKADDRPTFRIL---HNTILEVLED 648

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 101..191 CDD:472250 14/74 (19%)
Ig strand B 121..125 CDD:409353 0/1 (0%)
Ig strand C 134..138 CDD:409353 0/3 (0%)
Ig strand E 157..161 CDD:409353 1/10 (10%)
Ig strand F 171..176 CDD:409353 0/4 (0%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 20/133 (15%)
Ig strand B 216..220 CDD:409353 1/3 (33%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 0/3 (0%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 92/288 (32%)
btkNP_001123732.1 PH_Btk 8..167 CDD:269944 1/3 (33%)
SH3_BTK 209..264 CDD:212839 11/67 (16%)
SH2_Tec_Btk 267..370 CDD:198260 24/156 (15%)
Protein Kinases, catalytic domain 388..638 CDD:473864 90/273 (33%)

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