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Protein Alignment htl and fgfr2

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_012821350.1	Gene:	fgfr2 / 100124910	XenbaseID:	XB-GENE-1018296	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	694	Identity:	280/694 - (40%)
Similarity:	387/694 - (55%)	Gaps:	79/694 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 NANQSSTSSADLDDGAADDD---DNKADLPVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHAL 128
            |..::|:|..|.||....:|   ||.     |:.: |||.|.:|| ..|...|:.:.:.|.|.|.
Frog   135 NVTEASSSGDDEDDNDGSEDFTNDNN-----NIRA-PYWTNTEKMEKKLHAVPAANTVKLRCPAG 193

  Fly   129 GNPEPNITWYRNGTVDWTR-----GYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQ 188
            |||.|.:.|.:||. ::.:     || .::...|:|.||.:||.|.|.|||.|.|..|.|.|...
Frog   194 GNPTPRMRWLKNGK-EFKQEHRIGGY-KVRNQHWSLIMESVVPSDKGIYTCIVENEHGSINHTYH 256

  Fly   189 VIVSDRVNHKPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHGMTNCSNNR---- 247
            :.|.:|.:|:|||..| |.|.|.:|.......||..||......|: ::..:|      :|
Frog   257 LDVIERSSHRPILQAGLPANTTAMVGGDAEFVCKVYSDAQPHIRWVRYIEKNG------SRFGVD 315

  Fly   248 -------------SIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAG 299
                         ::..|:.:.|...||..|..|.|||:..||:|.|..:|:|.|    |  .|.
Frog   316 GLPYIKVLKAAGVNVTDEEIEVLYVRNVSFEDAGEYTCIAGNSIGISQHSAWLTV----H--PAT 374

  Fly   300 VASGSLHSTS-FVYIFVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIET---VHQWTKKVIIFK 360
            |:.|..:... ::.|.::...|||....:.:....|..:..|  |::..|   ||:.||::.:.:
Frog   375 VSPGEDNPVPYYMEIGIYSAGIFIIFCMVVICVVCRMRQGAK--KKKNFTGPPVHKLTKRIPLHR 437

  Fly   361 P-EGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPF---NEYEFPLDSNWELPRSHLVLGAT 421
            . ....|||.||:: ..|:|||    ||.|.:..:..|.   :|||.|.|..||..|..|.||..
Frog   438 QVTVSADSSSSMNS-TTPLVRI----TTRLLSSTDAMPLPNVSEYELPHDPLWEFSRDKLTLGKP 497

  Fly   422 LGEGAFGRVVMAEV---------NNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLL 477
            ||||.||:|||||.         .:..|||||:|:..|:.|:|.||.|||:|||||:|.||||||
Frog   498 LGEGCFGQVVMAEALGIDKDRPKESVTVAVKMLKDDATEKDLADLVSEMEMMKIIGKHKNIINLL 562

  Fly   478 GCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIAR 542
            |.|:|.|.||||||||..|||:.:|...||...:...|.::.|...    :|.|||:...:||||
Frog   563 GACTQGGTLYVIVEYAAKGNLRQYLRARRPLEMEYSFDVTRVPDEQ----MTFKDLVSCTYQIAR 623

  Fly   543 GMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQE 607
            ||:||||::|||||||||||||:::.|:||||||||||:.:.|||:|.||||||:||||||:|.:
Frog   624 GMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTTNGRLPVKWMAPEALFD 688

  Fly   608 KFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWH 672
            :.|..:|||||:|:|:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||
Frog   689 RVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPGNCTNELYMMMRDCWH 752

  Fly   673 FNADDRPPFTEIVEYMDKL--LQTKEDYLDVDIANLDTPPSTSD 714
            .....||.|.::||.:|::  |.|.|:|||:........||..|
Frog   753 AIPSHRPTFKQLVEDLDRILTLTTNEEYLDLSAPLEQYSPSFPD 796

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.