DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment htl and pdgfra

DIOPT Version :9

Sequence 1:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001096290.1 Gene:pdgfra / 100124862 XenbaseID:XB-GENE-6072920 Length:1091 Species:Xenopus tropicalis


Alignment Length:807 Identity:213/807 - (26%)
Similarity:334/807 - (41%) Gaps:214/807 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 WRNPKKMSFLQTRP-----SGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRN------- 155
            |:....:|.....|     :|..:|::|..|.|....:.||..|.   .||.|  |||       
 Frog   211 WKATHNISVEMEAPQTVFRTGETITISCIVLENEVVELKWYYPGQ---QRGVG--KRNVEESRVP 270

  Fly   156 ----RWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVN-HKPILMTGPLNLTLVVNST 215
                .:|||:.:....|.|.|.|.|.::    ..|.:||....:. |:    .|.:||..:..| 
 Frog   271 SQRLVYTLTIANATADDSGEYQCAVLHA----TLDNKVIKKTNITVHE----KGFINLEPMFGS- 326

  Fly   216 GSMHCKYLSDLTSKKAWIF----VPCHGMTNCSNNRSIIAED----------------KDQLDFV 260
                 :..::|...|::|.    .||..:....:||: ::|:                :.:|..:
 Frog   327 -----EEYANLHEVKSFIVDLHAYPCPRVFWLKDNRT-LSENLTEITTSTVTTKETRFQSKLKLI 385

  Fly   261 NVRMEQEGWYTCVESNSLGQSNSTAYLRVVRSLHVLEAGVASGSLHSTS---------------F 310
            ..:.|..|.||.|..|.....:.:..|::.....:||   .....|.||               .
 Frog   386 RAKEEDSGLYTLVAQNDAETKSYSFILQIKVPALILE---LVDEHHGTSGEQTVGCLAKGMPVPD 447

  Fly   311 VYIFVFGGLIFIFMTTLFVFYAIR----KMKHEKVLKQRIETVHQWTKKVI-------------- 357
            |...|...:......||:...||.    .|:..:..:..||:  |.|.|.:              
 Frog   448 VEWLVCKDIKRCNNDTLWSLLAINGSEISMETHQDYENTIES--QVTFKKVEETMAIRCIARNDL 510

  Fly   358 --------IFKPEGGGDSSGSMDTMIMPVVRI-----------QKQR--------TTVLQNGNEP 395
                    :..|....:.:.:...:::.|:.|           ||.|        .::..:|:|.
 Frog   511 GVVARELKLVAPTLRSELTVAAAVLVLLVIVIISLIVLVIIWKQKPRYEIRWRVIESISPDGHEY 575

  Fly   396 APFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVNNAI-------VAVKMVKEGHTDDD 453
            ...:..:.|.||.||..|..||||..||.||||:||........       |||||:|......:
 Frog   576 IYVDPMQLPYDSRWEFQRDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSE 640

  Fly   454 IASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRP----------- 507
            ..:|:.|:::|..:|.|:||:||||.|:::||:|:|.||..:|:|.::|:|||.           
 Frog   641 KQALMSELKIMTHLGAHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDNFQSRHPEKSK 705

  Fly   508 -----FGRD--------------------------------------------------QDRDSS 517
                 ||.:                                                  .||.:|
 Frog   706 KDLDIFGLNPADESTRSYVILSFENNGDYMDMKQADTMQYVPMLEMKEPSKYSDIQRSLYDRPAS 770

  Fly   518 --QPPPSPPAHVITEK-----------DLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYV 569
              :.|.|...:::::.           ||:.|.:|:||||::|||:.|:||||||||||::...:
 Frog   771 YKKKPLSEVKNILSDDGFDGFDGLTVLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAHGKI 835

  Fly   570 LKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPY 634
            :||.||||||||.....|....:..||:|||||||:.:..|.:.|||||:|||||||.:.|..||
 Frog   836 VKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSFGILLWEIFSLGGTPY 900

  Fly   635 PTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKLL--QTKED 697
            |.::.....|..:.||.||.||...:..:|.:|.:||:...:.||.|..:.:.::.||  :.|..
 Frog   901 PGMIVDSTFYNKIKSGYRMAKPDHATHEVYDIMVKCWNSEPEKRPSFRHLSDIVESLLPMEYKRC 965

  Fly   698 YLDV--DIANLDTPPSTSDEEEDETDN 722
            |..|  |....|.|..|  ....::||
 Frog   966 YETVLHDFLKSDHPAVT--RMRSDSDN 990

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
htlNP_524394.2 Ig 112..191 CDD:299845 25/94 (27%)
IG_like 113..191 CDD:214653 25/93 (27%)
IG_like 205..289 CDD:214653 19/103 (18%)
PKc_like 404..692 CDD:304357 128/373 (34%)
STYKc 416..688 CDD:214568 122/357 (34%)
pdgfraNP_001096290.1 Ig_3 29..101 CDD:404760
Ig 215..313 CDD:416386 27/106 (25%)
Ig strand A 215..219 CDD:409353 0/3 (0%)
Ig strand A' 226..230 CDD:409353 0/3 (0%)
Ig strand B 232..241 CDD:409353 2/8 (25%)
Ig strand C 246..251 CDD:409353 0/4 (0%)
Ig strand C' 254..256 CDD:409353 1/4 (25%)
Ig strand D 260..268 CDD:409353 4/9 (44%)
Ig strand E 272..280 CDD:409353 2/7 (29%)
Ig strand F 290..296 CDD:409353 2/5 (40%)
Ig strand G 301..307 CDD:409353 3/5 (60%)
Ig 316..416 CDD:416386 20/106 (19%)
PTKc_PDGFR_alpha 558..960 CDD:173653 132/401 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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