DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment htl and fgfr4

DIOPT Version :9

Sequence 1:	NP_524394.2	Gene:	htl / 42160	FlyBaseID:	FBgn0010389	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_571505.1	Gene:	fgfr4 / 100000160	ZFINID:	ZDB-GENE-980526-488	Length:	922	Species:	Danio rerio

Alignment Length:	694	Identity:	264/694 - (38%)
Similarity:	378/694 - (54%)	Gaps:	85/694 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GAADDDDNKADL----------PVNVSSKPYWRNPKKM-SFLQTRPSGSLLTLNCHALGNPEPNI 135
            |:.||||....|          .|.:|..|||.:.::| ..|...|:|:.:...|.|.|:|.|.|
Zfish   229 GSGDDDDEDNGLDDIGPETENDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTI 293

  Fly   136 TWYRNGTV---DWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIVSDRVNH 197
            .|.:||..   :...|...|:...|:|.||.:||.|.|||:|.|.|..|.|.|...:.|.:|..|
Zfish   294 RWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPH 358

  Fly   198 KPILMTG-PLNLTLVVNSTGSMHCKYLSDLTSKKAWI-FVPCHG---------MTNCSNNRSIIA 251
            :|||..| |.|.|.:|.......||..||......|: .:..:|         ........|:..
Zfish   359 RPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNM 423

  Fly   252 EDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVV------RSLHVLEAGVASGSLHSTSF 310
            .:.:.|...|:.||..|.|:|:..||:|.|:.:|:|.|:      :.:.::||......::::.|
Zfish   424 SEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGF 488

  Fly   311 VYIFVFGGLIFIFMTTLFV------FYAIRKMKHEKVLKQRIETVHQWTKKVIIFKPEGGGDSSG 369
            :.:.:  .::.:.:..:.|      |..:...|..|...:|..:|.              .:|||
Zfish   489 LALVM--AIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVE--------------SNSSG 537

  Fly   370 SMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAE 434
            .....:|.|.|:....:.:|      |...|:|.|.|.:||.||.:|.||..||||.||:||.||
Zfish   538 KSSASLMRVARLSSSCSPML------AGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAE 596

  Fly   435 ---VNN------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIV 490
               :|.      |.|||||:|:..||.|:|.|:.|||:||::.:|.|||||||.|:|:|||||:|
Zfish   597 AYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLV 661

  Fly   491 EYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHR 555
            |||..|:|:::|...||.|.|...|.::.|...    :|.|||:..|:|:||||:||||:|||||
Zfish   662 EYASKGSLREYLRARRPPGMDYTFDVTKVPEEQ----LTFKDLVSCAYQVARGMEYLASKRCIHR 722

  Fly   556 DLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYG 620
            |||||||||::|.|:|||||||||.:...|||:|.||||:|:||||||:|.::.|..:|||||:|
Zfish   723 DLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFG 787

  Fly   621 ILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIV 685
            :|:|||.|.|..|||.| ..|||:..|..|.||:||:.|:..:|:.||:|||.....||.|.::|
Zfish   788 VLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLV 851

  Fly   686 EYMDK-LLQTKEDYLDVDIANLDTP-----PSTSDEEED-ETDN 722
            |.:|: |:...::|||     |.||     ||..|.... .:||
Zfish   852 EELDRVLVSISDEYLD-----LSTPFEQYSPSCEDTSSSCSSDN 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
htl	NP_524394.2	Ig	112..191	CDD:299845	30/81 (37%)
		IG_like	113..191	CDD:214653	29/80 (36%)
		IG_like	205..289	CDD:214653	24/93 (26%)
		PKc_like	404..692	CDD:304357	159/297 (54%)
		STYKc	416..688	CDD:214568	152/280 (54%)
fgfr4	NP_571505.1	IG_like	44..135	CDD:214653
		Ig	52..136	CDD:299845
		IG_like	150..224	CDD:214653
		IGc2	156..212	CDD:197706
		Ig2_FGFR	268..352	CDD:143265	30/83 (36%)
		IG_like	273..352	CDD:214653	29/78 (37%)
		IG_like	367..461	CDD:214653	24/93 (26%)
		Ig3_FGFR-2	375..462	CDD:143266	20/86 (23%)
		PTKc_FGFR4	565..877	CDD:133230	166/321 (52%)
		Pkinase_Tyr	578..854	CDD:285015	152/280 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	1	1.010	-	-		QHG50158
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.740