DRSC/TRiP Functional Genomics Resources

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Protein Alignment MAP3K4 and Pak3

DIOPT Version :10

Sequence 1:NP_005913.3 Gene:MAP3K4 / 4216 HGNCID:6856 Length:1608 Species:Homo sapiens
Sequence 2:NP_001262638.1 Gene:Pak3 / 41995 FlyBaseID:FBgn0044826 Length:583 Species:Drosophila melanogaster


Alignment Length:461 Identity:122/461 - (26%)
Similarity:202/461 - (43%) Gaps:88/461 - (19%)


- Green bases have known domain annotations that are detailed below.


Human  1198 AAVAASRPSPSG-GDSVLPKSISSAHDTRGSSVPENDRLASIAAELQFRSLSRHSSPTEERDEPA 1261
            ::.|....|.|| |.|....:.||.:|:...|....|.|..:..||:.....|.:.....::.|.
  Fly   126 SSTATETESSSGCGSSAGNSNSSSINDSSQQSTVPLDALEEVFKELKTNLEHRETLKAAPQEPPP 190

Human  1262 YP------------------------------RGDSSGSTRRSWELRTLISQ----SKDTASKLG 1292
            .|                              |.|.....:......|:|.:    ::|..:...
  Fly   191 VPPKKSPHTIPPKPQIKPKPRVTQKFSRTSDIRRDEDSDNQHKINTDTIIIKPAVGAQDAGADDN 255

Human  1293 PIEAIQKSVRLFEEKR--------YREMRRKNIIGQVC--DTPKSYDNVMHVGLRKVTFKWQRGN 1347
            |.|.|   :|..:|||        |.|:|      .:|  |.|:.              :::...
  Fly   256 PDETI---LRRSKEKRAQKTDAEIYVELR------AICNSDDPRE--------------RYKTTQ 297

Human  1348 KIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVEL-- 1410
            ::|:|..|.|:....:.....:|:|.|..:....|.:..|  |:::.:...|.|||.:....|  
  Fly   298 EVGKGASGIVFIAADLQNESQVAVKTIDMKNQSSKDLILT--EIRVLKDFNHKNLVNFLDAYLLE 360

Human  1411 HREEMYIFMEYCDEGTLEE-VSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSS 1474
            ..:::::.|||.|.|.|.: |:...::|..|....::...||:.||..||:|||||..|:.|...
  Fly   361 PEDQLWVVMEYMDGGPLTDVVTETVMKERQIACVCRETLYAISFLHAKGIIHRDIKSDNVLLGMD 425

Human  1475 GLIKLGDFGCSVKLKNN--AQTMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIE 1537
            |.:|:.|||....::.:  .|||       :||..:|||||:||.|   :|:..||||:|.:.||
  Fly   426 GSVKVTDFGFCANIEGDEKRQTM-------VGTPYWMAPEVVTRKK---YGKKVDIWSIGIMAIE 480

Human  1538 MVTGKRPWHEYEHNFQIMYKVGMGHKPPIP--ERLSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1600
            |:.|:.| :.||...:.:|.:....:|.|.  ::|||..:|||..||:.:...|.||.:||.|.|
  Fly   481 MIEGQPP-YLYETPLRALYLIAANGRPDIKSWDKLSPNLQDFLDRCLQVEVDRRATADELLSHPF 544

Human  1601 VKVCTD 1606
            :..|::
  Fly   545 LNDCSE 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAP3K4NP_005913.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..136
MEKK4_N 51..1269 CDD:466077 19/101 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..478
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1157..1190
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1231 9/29 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1244..1274 5/59 (8%)
STKc_MEKK4 1342..1601 CDD:270796 85/265 (32%)
Pak3NP_001262638.1 PBD 19..76 CDD:395634
Protein Kinases, catalytic domain 288..545 CDD:473864 86/283 (30%)
Blue background indicates that the domain is not in the aligned region.

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