DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MAP3K4 and Map3k4

DIOPT Version :9

Sequence 1:NP_005913.3 Gene:MAP3K4 / 4216 HGNCID:6856 Length:1608 Species:Homo sapiens
Sequence 2:NP_036078.2 Gene:Map3k4 / 26407 MGIID:1346875 Length:1597 Species:Mus musculus


Alignment Length:1610 Identity:1422/1610 - (88%)
Similarity:1488/1610 - (92%) Gaps:15/1610 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MREAAAALVPPPAFAVTPAAAMEEPPPPPPPPPPPPEPETESEPECCLAARQEGTLGDSACKSPE 65
            ||:|.|..|||||.|.||||||||..|.|||.|.|       :||||.|||||..||:||.||.|
Mouse     1 MRDAIAEPVPPPALADTPAAAMEELRPAPPPQPEP-------DPECCPAARQECMLGESARKSME 58

Human    66 SDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHKDTGK 130
            ||.||||||||||.|||||||||||||||:|.|||||:.||||||||||||||.|:|.||||.||
Mouse    59 SDPEDFSDETNTETLYGTSPPSTPRQMKRLSAKHQRNSAGRPASRSNLKEKMNTPSQSPHKDLGK 123

Human   131 TVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSLPKKSIPDVDLNKPYLSLGCSN 195
            .||.||||||||||||||.|||||||.|||.|||||||||.||||||||||||||||||||||||
Mouse   124 GVETVEEYSYKQEKKIRATLRTTERDHKKNAQCSFMLDSVAGSLPKKSIPDVDLNKPYLSLGCSN 188

Human   196 AKLPVSVPMPIARPARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTSGFWLNRS 260
            ||||||:||||||.|||||||||||||||||||||||||||||||||||||||||||:.||.|||
Mouse   189 AKLPVSMPMPIARTARQTSRTDCPADRLKFFETLRLLLKLTSVSKKKDREQRGQENTAAFWFNRS 253

Human   261 NELIWLELQAWHAGRTINDQDFFLYTARQAIPDIINEILTFKVDYGSFAFVRDRAGFNGTSVEGQ 325
            |||||||||||||||||||||.|||||||||||||||||||||:|||.||..:.|||||..||||
Mouse   254 NELIWLELQAWHAGRTINDQDLFLYTARQAIPDIINEILTFKVNYGSIAFSSNGAGFNGPLVEGQ 318

Human   326 CKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIEALYPSLQALQKDYEKYAAKDFQDRV 390
            |:....|..||.|::|||||||||||||||||||||||:|||||||||||||||:||||||:|||
Mouse   319 CRTPQETNRVGCSSYHEHLQRQRVSFEQVKRIMELLEYMEALYPSLQALQKDYERYAAKDFEDRV 383

Human   391 QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGNEPEYEGDDTEGELKELE 455
            |||||||||||||||||||||||||||||||||||||||||||||||.|||.|.:|||.||:|||
Mouse   384 QALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPVFEIPSPRPSKGYEPEDEVEDTEVELRELE 448

Human   456 SSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCISKKLERLESEDDSLGWGAPDWSTEAGFSRH 520
            |.|:||:||....|||||:|...|...|.:|:.|:|:||||||||:||:|||..|...||  |||
Mouse   449 SGTEESDEEPTPSPRVPELRLSTDAILDSRSQGCVSRKLERLESEEDSIGWGTADCGPEA--SRH 511

Human   521 CLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQRARIALVKNDRPVEFSEFPDPMWGSDYVQL 585
            ||||||||||||||||||||||||||||||:|||||||:||||:|||||||:||.||||||||||
Mouse   512 CLTSIYRPFVDKALKQMGLRKLILRLHKLMNGSLQRARVALVKDDRPVEFSDFPGPMWGSDYVQL 576

Human   586 SRTPPSSEEKCSAVSWEELKAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQ 650
            |.||||||:||||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   577 SGTPPSSEQKCSAVSWEELRAMDLPSFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSLLSIKQ 641

Human   651 LVRECKEVLKGGLLMKQYYQFMLQEVLEDLEKPDCNIDAFEEDLHKMLMVYFDYMRSWIQMLQQL 715
            |||||||||||||||||||||||||||..|||.|||:|||||||.||||||||||||||||||||
Mouse   642 LVRECKEVLKGGLLMKQYYQFMLQEVLGGLEKTDCNMDAFEEDLQKMLMVYFDYMRSWIQMLQQL 706

Human   716 PQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTS 780
            ||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||.|||
Mouse   707 PQASHSLKNLLEEEWNFTKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLESGLQESCAELWTS 771

Human   781 ADDSSASDEIRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVL 845
            |||:.|:||:||||||||||||||||||||||||||||||||||||||||||.|||..|:|||.|
Mouse   772 ADDNGAADELRRSVIEISRALKELFHEARERASKALGFAKMLRKDLEIAAEFVLSASARELLDAL 836

Human   846 KSKQYVKVQIPGLENLQMFVPDTLAEEKSIILQLLNAAAGKDCSKDSDDVLIDAYLLLTKHGDRA 910
            |:||||||||||||||.:||||:|||||.|||||||||.|||||||.|||.:||:||||||||||
Mouse   837 KAKQYVKVQIPGLENLHVFVPDSLAEEKKIILQLLNAATGKDCSKDPDDVFMDAFLLLTKHGDRA 901

Human   911 RDSEDSWGTWEAQPVKVVPQVETVDTLRSMQVDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQE 975
            |||||.||||||:.||:|||||||||||||||||||||||:||||.:||||||||||||||:..|
Mouse   902 RDSEDGWGTWEARAVKIVPQVETVDTLRSMQVDNLLLVVMESAHLVLQRKAFQQSIEGLMTVRHE 966

Human   976 QTSSQPVIAKALQQLKNDALELCNRISNAIDRVDHMFTSEFDAEVDESESVTLQQYYREAMIQGY 1040
            ||||||:|||.||||||||||||||||:||||||||||.||||||:||||.||||||||||||||
Mouse   967 QTSSQPIIAKGLQQLKNDALELCNRISDAIDRVDHMFTLEFDAEVEESESATLQQYYREAMIQGY 1031

Human  1041 NFGFEYHKEVVRLMSGEFRQKIGDKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPA 1105
            ||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||
Mouse  1032 NFGFEYHKEVVRLMSGEFRQKIGDKYISFAQKWMNYVLTKCESGRGTRPRWATQGFDFLQAIEPA 1096

Human  1106 FISALPEDDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPT 1170
            |||||||||||||||||||||||||||||||||    |||||||||:||||||||||||||||||
Mouse  1097 FISALPEDDFLSLQALMNECIGHVIGKPHSPVT----AIHRNSPRPVKVPRCHSDPPNPHLIIPT 1157

Human  1171 PEGFSTRSMPSDARSHGS--PAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPEND 1233
            ||||||||:|||||:||:  .||||.||||..||.||.|.|||||..|.:::|.|||||||||||
Mouse  1158 PEGFSTRSVPSDARTHGNSVAAAAAVAAAATTAAGRPGPGGGDSVPAKPVNTAPDTRGSSVPEND 1222

Human  1234 RLASIAAELQFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQ 1298
            |||||||||||||||||||||||||||||||.||||||||||||||||||:||:|||.|||||||
Mouse  1223 RLASIAAELQFRSLSRHSSPTEERDEPAYPRSDSSGSTRRSWELRTLISQTKDSASKQGPIEAIQ 1287

Human  1299 KSVRLFEEKRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISV 1363
            ||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1288 KSVRLFEERRYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISV 1352

Human  1364 DTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE 1428
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1353 DTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE 1417

Human  1429 EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQ 1493
            |||||||||||||||:||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse  1418 EVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQ 1482

Human  1494 TMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV 1558
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1483 TMPGEVNSTLGTAAYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKV 1547

Human  1559 GMGHKPPIPERLSPEGKDFLSHCLESDPKMRWTASQLLDHSFVKVCTDEE 1608
            |||||||||||||||||.|||||||||||:||||||||||:|||||||||
Mouse  1548 GMGHKPPIPERLSPEGKAFLSHCLESDPKIRWTASQLLDHAFVKVCTDEE 1597

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MAP3K4NP_005913.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..136 97/134 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..478 33/48 (69%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1157..1190 29/34 (85%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1231 18/28 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1244..1274 28/29 (97%)
STKc_MEKK4 1342..1601 CDD:270796 253/258 (98%)
Map3k4NP_036078.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..129 97/134 (72%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 424..465 27/40 (68%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1137..1157 18/19 (95%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1190..1220 19/29 (66%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1233..1263 28/29 (97%)
STKc_MEKK4 1331..1590 CDD:270796 253/258 (98%)
S_TKc 1332..1590 CDD:214567 252/257 (98%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C83971416
Domainoid 1 1.000 2307 1.000 Domainoid score I214
eggNOG 1 0.900 - - E1_KOG4645
HGNC 1 1.500 - -
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H31346
Inparanoid 1 1.050 2844 1.000 Inparanoid score I700
Isobase 1 0.950 - 0 Normalized mean entropy S4833
NCBI 1 1.000 - -
OMA 1 1.010 - - QHG46651
OrthoDB 1 1.010 - - D55144at2759
OrthoFinder 1 1.000 - - FOG0002637
OrthoInspector 1 1.000 - - oto122450
orthoMCL 1 0.900 - - OOG6_104404
Panther 1 1.100 - - LDO PTHR48016
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1672
SonicParanoid 1 1.000 - - X2354
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1919.250

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