Protein Alignment MAP3K4 and mtk-1

DIOPT Version :9

• Sequence 1: NP_005913.3
• Gene: MAP3K4 / 4216
• HGNCID: 6856
• Length: 1608
• Species: Homo sapiens
• Sequence 2: NP_001367356.1
• Gene: mtk-1 / 172246
• WormBaseID: WBGene00003472
• Length: 1420
• Species: Caenorhabditis elegans
• Alignment Length: 1675
• Identity: 348/1675 - (20%)
• Similarity: 625/1675 - (37%)
• Gaps: 482/1675 - (28%)

Human    62 KSPESDLEDFSDETNTENLYGTSPPSTPRQMKRMSTKHQRNNVGRPASRSNLKEKMNAPNQPPHK 126
            ||......|..|:...:..|..||.|:.....|.....:|:|             .|:.|..|..
 Worm    65 KSKTERDRDMYDDMYDDEGYAASPTSSSSCTYRCIPILERSN-------------RNSQNYLPSA 116

Human   127 DTGKTVENVEEYSYKQEKKIRAALRTTERDRKKNVQCSFMLDSVGGSL-PKKSIPDVDLNKPYLS 190
            ::..:..|....|:...:.|                   :|.|...|: |::::....|:.....
 Worm   117 ESSSSDSNDRVISHPNHRPI-------------------LLYSTALSMAPQQNLSVESLSDALDE 162

Human   191 L-GCSNAKLPVSVPMPIARPARQTSR--------TDCPADRLKFFETLRLLLKLTSVSKKKDREQ 246
            | |...:||.:.:...:.:...:.|:        .:||    :|.:|:||:::
 Worm   163 LEGADRSKLHMEITQFLKKADGEKSKQIQMSQRLMNCP----QFGQTMRLIVE------------ 211

Human   247 RGQENTSGFWLNRSNELIWLELQAWHA----GRTIN-------DQDFFLYTARQAIPDIINEILT 300
             ..|:|...:.|    ::||.|:::.:    ||.:.       .:|..:..||:....:::.|..
 Worm   212 -ESEHTRYTFEN----ILWLILKSYFSTTSTGRDVMIGKSEWIAEDEKIVKARKQYMMVMDMIKE 271

Human   301 FKVDYGSFAFVRDRAGFNGTSVEGQCKATPGTKIVGYSTHHEHLQRQRVSFEQVKRIMELLEYIE 365
            ||.:.|.    .|:......|:..:.:.:|           ::.:..|.:.::|..:::..|.:.
 Worm   272 FKFEVGK----NDKDDSPFESLNRRMEFSP-----------DYCENLRDARKRVSDVLDKYETLV 321

Human   366 ALYPSLQALQK----DYEKYAAKDFQDRVQALCLWLNITKDLNQKLRIMGTVLGIKNLSDIGWPV 426
            .|:|:..||.|    |..:...|..:.|:.::.:|||...||..|.:.:|.:..|:.:.|
 Worm   322 DLFPNQNALWKVVELDRGEAEKKLLEGRMTSMRVWLNTLDDLTDKFKALGVLFEIETMPD----- 381

Human   427 FEIPSPRPSKGNEPEYEGDDTEGELKELESSTDESEEEQISDPRVPEIRQPIDNSFDIQSRDCIS 491
                                                                       :.:|..
 Worm   382 -----------------------------------------------------------AEECWF 387

Human   492 KKLERLESEDDSLGWGAPDWSTEAGFSRHCLTSIYRPFVDKALKQMGLRKLILRLHKLMDGSLQR 556
            :.|:    |::.:            |:...:.:::..:|..:|...|::|::.|:.|:::.:|.:
 Worm   388 RPLD----ENNKI------------FALEDVRAVFLEYVKNSLNLKGMKKVLSRVEKIIELTLVK 436

Human   557 ARIALVK-----------NDRPVEFSEFPDPMWGSDYVQLSRTPPSSEEKCSAVSWEELKAMDLP 610
            ..|.:.|           |.....||:.....:| |.::.        ..|::.|    .:::||
 Worm   437 TAILMQKPPTSYAAATASNGPSFPFSQTMKDRYG-DMIEW--------RFCNSTS----ISLNLP 488

Human   611 SFEPAFLVLCRVLLNVIHECLKLRLEQRPAGEPSL--LSIKQLVRECKEVLKGGLLMKQYYQFML 673
            .....|..|..|.:.::...|::|....|.....|  |:...::.:.::.::..:.:|:.|..:|
 Worm   489 PLNNLFFFLVAVPMQLVVHWLEIRAATEPPDSCLLDELTFDAMITDSRDCVEEAVRIKKNYLTIL 553

Human   674 QEVLEDLEKP----DCNIDAFEEDLHKMLMVYFDYMRSW--IQMLQQLPQASHSLKNLLEEEWNF 732
            |.:......|    ....:.:..|:.|.   |..|::.|  ...:::.|..   |.:.||.||:.
 Worm   554 QSMCSKCAMPGFLYPLKYNTYVLDVFKK---YIHYVKCWSNCDSVRKDPPL---LFSRLEMEWSS 612

Human   733 TKEITHYIRGGEAQAGKLFCDIAGMLLKSTGSFLEFGLQESCAEFWTSADDSSASDE-------- 789
            ..:....::.........:|||...|::...........|.....:....||...||
 Worm   613 AVQCAKSVKSALELLCTTYCDIVESLIREVVEVYADDQIEDIKNRYVYNTDSENEDEEDDEDMIT 677

Human   790 ---IRRSVIEISR------ALKELFHEARERASKALGFAKMLRKDLEIAAEFRLSAPVRDLLDVL 845
               .::.::|:..      .|..|..|.:||..:.....::...|...|..:.|.:
 Worm   678 IGSPKKPLVELKAKHRFMLELNSLTREVKERELRIFSLLRITLNDSHDAVGYELRS--------- 733

Human   846 KSKQYVKVQIPGLENLQMF---VPDTLAEEKSIILQLLNAAAGKDCSKDSDD------------- 894
                       |::..|||   |||      ..::||..|:..:....|.||
 Worm   734 -----------GVDRAQMFHEMVPD------FCLIQLTMASDEQGDVNDDDDHVNLKIVLFVYRT 781

Human   895 ----VLIDAYLLLTKHGDRARDSEDSWGT--------------WEAQPVKVVPQVETVDTLRSMQ 941
                ..::..:|....|.:..|     |.              |:.:.||:|...||....|.::
 Worm   782 SVDKAYVETCMLAISEGRKIDD-----GCIVIVPDKDHKLRKHWKGRVVKIVIDEETRICYRWLR 841

Human   942 VDNLLLVVMQSAHLTIQRKAFQQSIEGLMTLCQEQTSSQPVIAKALQQLKNDAL-----ELCNRI 1001
            .|.:|.:...|....::.| ::..::.:...|    ||..:|...:|||..::|     |...||
 Worm   842 DDIILCLANGSIRADMEHK-YKNFLKCISPAC----SSNFLITSRIQQLTEESLLPHLDEERKRI 901

Human  1002 SNAIDRVDHMFTSEFDAEVDESES----------VTLQQYYREAMIQGYNFGFEYHKEVVRLMSG 1056
            ...:::      :|...|..|.:|          ..|::::..|        |:.|::|.:::|.
 Worm   902 GILLEK------TEIRLEPKEEQSKEKSALSSLGFKLEKHFLVA--------FQIHRDVAKVVSD 952

Human  1057 EFRQKIG----DKYISFARKWMNYVLTKCESGRGTRPRWATQGFDFLQAI-EPAFISALPE---- 1112
            .|...:|    :|.::..|:||.||..|......|.|.||:.||.|||.| ||.:.:  ||
 Worm   953 SFMDGLGNEMVEKALALTRQWMQYVEVKSTIPSPTLPMWASPGFTFLQYITEPRWSN--PEIMTN 1015

Human  1113 DDFLSLQALMNECIGHVIGKPHSPVTGLYLAIHRNSPRPMKVPRCHSDPPNPHLIIPTPEGFSTR 1177
            |.|.....|:.                |:.|         ||.:..|:       |.|| |.:..
 Worm  1016 DQFQEFNDLVK----------------LFEA---------KVIKSSSN-------IGTP-GNTGT 1047

Human  1178 SMPSDARSHGSPAAAAAAAAAAVAASRPSPSGGDSVLPKSISSAHDTRGSSVPENDRLASIAAEL 1242
            .|..:.||..|                           |:.||:.:....:..||..|     :|
 Worm  1048 PMQRNTRSTSS---------------------------KTSSSSMENHKRTRKENQML-----KL 1080

Human  1243 QFRSLSRHSSPTEERDEPAYPRGDSSGSTRRSWELRTLISQSKDTASKLGPIEAIQKSVRLFEEK 1307
            |                                ||                           |:|
 Worm  1081 Q--------------------------------EL---------------------------EDK 1086

Human  1308 RYREMRRKNIIGQVCDTPKSYDNVMHVGLRKVT----FKWQRGNKIGEGQYGKVYTCISVDTGEL 1368
            |.|.......||:|. |..:..|.:....:|:|    |:|...:.|..|.:|.|:..:.:|:..:
 Worm  1087 RNRIDYDNLQIGKVI-TDDNRRNFVLATDKKITTKAPFQWALLDHIASGSFGSVHRAMDIDSHRV 1150

Human  1369 MAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSRL 1433
            :|.|.:|.|..:||.|:   .|:.||..:.|.|||:|:||::...::.||||||.:||||.:...
 Worm  1151 IAAKVMRIQRENHKAIE---SEINIFRQLIHENLVKYYGVQVEDSDVIIFMEYCSQGTLERICHG 1212

Human  1434 GLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGE 1498
            .:...::|.|:..:..|:..||.|.|:|||||.|||||....::||||||||.:|..:: |:.||
 Worm  1213 KMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESS-TVYGE 1276

Human  1499 VNSTLGTAAYMAPEVI-------TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMY 1556
            ..:|.||..:||||:.       |.....|:||:.|||:||..|:.|:|||.|: |.:...||.:
 Worm  1277 FQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPF-EGQTRHQIAF 1340

Human  1557 KVGM-GHKPPIPERLS--PEGKDFLSHCLESDPKMRWTASQLLDHSFVKV 1603
            .:.. ..||..|:...  |:.|.|..:|.|..|..|.||::||..:|..|
 Worm  1341 ALCFRKQKPTYPDIADKRPDVKRFFDNCFEFLPNDRPTAAELLQTTFANV 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..136		15/73 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	429..478		0/48 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1157..1190		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1202..1231		3/28 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1244..1274		0/29 (0%)
		STKc_MEKK4	1342..1601	CDD:270796	101/268 (38%)
mtk-1	NP_001367356.1	PKc_like	1125..1388	CDD:419665	101/267 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I2312
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I2107
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46651
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto22043
orthoMCL	1	0.900	-	-		OOG6_104404
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1672
SonicParanoid	1	1.000	-	-		X2354
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.910