DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7794 and TUB1

DIOPT Version :9

Sequence 1:	NP_650674.1	Gene:	CG7794 / 42159	FlyBaseID:	FBgn0038565	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_013625.1	Gene:	TUB1 / 854889	SGDID:	S000004550	Length:	447	Species:	Saccharomyces cerevisiae

Alignment Length:	452	Identity:	218/452 - (48%)
Similarity:	308/452 - (68%)	Gaps:	14/452 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIIQIHIGQAGVQIANACWELFCLEHGILANGRL---TQSPM--DDSFLTFFEFTSHQPCVQPRL 65
            |:|.|::||||.||.||||||:.|||||..:|.|   ...|.  ::.|.|||..|.:...| ||.
Yeast     3 EVISINVGQAGCQIGNACWELYSLEHGIKPDGHLEDGLSKPKGGEEGFSTFFHETGYGKFV-PRA 66

  Fly    66 VMIDTEPTVIDEIRTGSYRNLFHPDTLITGKDDSGSNFARGYNLMASELLDRSMNAIRRVADRCR 130
            :.:|.||.||||:|.|.|::||||:.||:||:|:.:|:|||:..:..|:|...::.||::||:|.
Yeast    67 IYVDLEPNVIDEVRNGPYKDLFHPEQLISGKEDAANNYARGHYTVGREILGDVLDRIRKLADQCD 131

  Fly   131 NLRGFLVFRAIGGGSGSGLGTRIMERLVEDFGKKMTVVEFLVYPSPSISPVIVEPYNALLAAHFS 195
            .|:|||...::|||:|||||:.::|.|..::||| :.:||.|||:|.:|..:|||||.:|..|.:
Yeast   132 GLQGFLFTHSLGGGTGSGLGSLLLEELSAEYGKK-SKLEFAVYPAPQVSTSVVEPYNTVLTTHTT 195

  Fly   196 MDCADVSFIVDNEALYDICANTLNVPAPTYTNLNRIIAQVVSSFTASQRFGGGSTVSFQELQTNL 260
            ::.||.:|:|||||:||:|...|::|.|::.|||.:|||||||.|||.||.|...|...|.||||
Yeast   196 LEHADCTFMVDNEAIYDMCKRNLDIPRPSFANLNNLIAQVVSSVTASLRFDGSLNVDLNEFQTNL 260

  Fly   261 VPYPRIHYPLINYAPLVPISHSQFVNMSTAQLTGQCFQMSNQMVRCNPSHGKYMASVLLYRGDIA 325
            |||||||:||::|:|::..|.:...:.|.:::|..||:..||||:|:|..|||||:.||||||:.
Yeast   261 VPYPRIHFPLVSYSPVLSKSKAFHESNSVSEITNACFEPGNQMVKCDPRDGKYMATCLLYRGDVV 325

  Fly   326 PNEINTALENIKRNRSFRFVDWSPTGFKIGVSPMPPYYVPGGDLAPTNRACVAISNNTNIRIAWC 390
            ..::..|:|.:|..::.:.|||.|||||||:...||...|...||..:||...:||.|:|..||.
Yeast   326 TRDVQRAVEQVKNKKTVQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWK 390

  Fly   391 RLVNKFDKLYQRRAFVYHYVGEGLEEGNFNEASENICQLVHDYLEVDASAPTSRRDSDPEED 452
            |:..|||.:|.:||||:.|||||:|||.|.||.|::..|..||:||.|       ||..||:
Yeast   391 RIDRKFDLMYAKRAFVHWYVGEGMEEGEFTEAREDLAALERDYIEVGA-------DSYAEEE 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7794	NP_650674.1	alpha_tubulin	5..436	CDD:276955	211/434 (49%)
CG7794	NP_650674.1	PTZ00335	6..439	CDD:185562	213/437 (49%)
TUB1	NP_013625.1	alpha_tubulin	2..436	CDD:276955	211/434 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S25
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000082
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11588
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820