DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7794 and TUB2

DIOPT Version :9

Sequence 1:	NP_650674.1	Gene:	CG7794 / 42159	FlyBaseID:	FBgn0038565	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_116616.1	Gene:	TUB2 / 850506	SGDID:	S000001857	Length:	457	Species:	Saccharomyces cerevisiae

Alignment Length:	451	Identity:	162/451 - (35%)
Similarity:	257/451 - (56%)	Gaps:	18/451 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIIQIHIGQAGVQIANACWELFCLEHGILANGRLTQSPMDD----SFLTFFEFTSHQPCVQPRLV 66
            |||.|..||.|.||..|.||..|.|||:..||  |....||    ....:|...|....| ||.:
Yeast     3 EIIHISTGQCGNQIGAAFWETICGEHGLDFNG--TYHGHDDIQKERLNVYFNEASSGKWV-PRSI 64

  Fly    67 MIDTEPTVIDEIRTGSYRNLFHPDTLITGKDDSGSNFARGYNLMASELLDRSMNAIRRVADRCRN 131
            .:|.||..||.:|..:..|||.||..|.|:..:|:.:|:|:....:||:|..|:.|||.|:.|.:
Yeast    65 NVDLEPGTIDAVRNSAIGNLFRPDNYIFGQSSAGNVWAKGHYTEGAELVDSVMDVIRREAEGCDS 129

  Fly   132 LRGFLVFRAIGGGSGSGLGTRIMERLVEDFGKKMTVVEFLVYPSPSISPVIVEPYNALLAAHFSM 196
            |:||.:..::|||:|||:||.::.::.|:|..:| :..|.|.|||..|..:||||||.|:.|..:
Yeast   130 LQGFQITHSLGGGTGSGMGTLLISKIREEFPDRM-MATFSVLPSPKTSDTVVEPYNATLSVHQLV 193

  Fly   197 DCADVSFIVDNEALYDICANTLNVPAPTYTNLNRIIAQVVSSFTASQRFGGGSTVSFQELQTNLV 261
            :.:|.:|.:|||||||||..||.:..|:|.:||.:::.|:|..|.|.|:.|......::|..|||
Yeast   194 EHSDETFCIDNEALYDICQRTLKLNQPSYGDLNNLVSSVMSGVTTSLRYPGQLNSDLRKLAVNLV 258

  Fly   262 PYPRIHYPLINYAPLVPISHSQFVNMSTAQLTGQCFQMSNQMVRCNPSHGKYMASVLLYRGDIAP 326
            |:||:|:.::.||||..|....|.:::..:||.|.|...|.|...:|.:|:|:.....:||.::.
Yeast   259 PFPRLHFFMVGYAPLTAIGSQSFRSLTVPELTQQMFDAKNMMAAADPRNGRYLTVAAFFRGKVSV 323

  Fly   327 NEINTALENIKRNRSFRFVDWSPTGFKIGVSPMPPYYVPGGDLAPTNRACVAISNNTNIRIAWCR 391
            .|:...:..::...|..||:|.|...:..|..:.|   .|.|:|.|     .|:|:|:|:..:.|
Yeast   324 KEVEDEMHKVQSKNSDYFVEWIPNNVQTAVCSVAP---QGLDMAAT-----FIANSTSIQELFKR 380

  Fly   392 LVNKFDKLYQRRAFVYHYVGEGLEEGNFNEASENICQLVHDYLEVDASAPTSRRDSDPEED 452
            :.::|..:::|:||::.|..||::|..|:||..|:..||.:|.:...:  |...|.:.:|:
Yeast   381 VGDQFSAMFKRKAFLHWYTSEGMDELEFSEAESNMNDLVSEYQQYQEA--TVEDDEEVDEN 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7794	NP_650674.1	alpha_tubulin	5..436	CDD:276955	159/433 (37%)
CG7794	NP_650674.1	PTZ00335	6..439	CDD:185562	159/436 (36%)
TUB2	NP_116616.1	beta_tubulin	2..426	CDD:276956	159/434 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5023
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810