back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7794 and TUBB4B

DIOPT Version :10

Sequence 1:	NP_650674.1	Gene:	CG7794 / 42159	FlyBaseID:	FBgn0038565	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_006079.1	Gene:	TUBB4B / 10383	HGNCID:	20771	Length:	445	Species:	Homo sapiens

Alignment Length:	452	Identity:	150/452 - (33%)
Similarity:	258/452 - (57%)	Gaps:	18/452 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EIIQIHIGQAGVQIANACWELFCLEHGILANGRL---TQSPMDDSFLTFFEFTSHQPCVQPRLVM 67
            ||:.:..||.|.||....||:...||||...|..   :...::...:.:.|.|..:  ..||.|:
Human     3 EIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGK--YVPRAVL 65

  Fly    68 IDTEPTVIDEIRTGSYRNLFHPDTLITGKDDSGSNFARGYNLMASELLDRSMNAIRRVADRCRNL 132
            :|.||..:|.:|:|.:..:|.||..:.|:..:|:|:|:|:....:||:|..::.:|:.|:.|..|
Human    66 VDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCL 130

  Fly   133 RGFLVFRAIGGGSGSGLGTRIMERLVEDFGKKMTVVEFLVYPSPSISPVIVEPYNALLAAHFSMD 197
            :||.:..::|||:|||:||.::.::.|::..:: :..|.|.|||.:|..:||||||.|:.|..::
Human   131 QGFQLTHSLGGGTGSGMGTLLISKIREEYPDRI-MNTFSVVPSPKVSDTVVEPYNATLSVHQLVE 194

  Fly   198 CADVSFIVDNEALYDICANTLNVPAPTYTNLNRIIAQVVSSFTASQRFGGGSTVSFQELQTNLVP 262
            ..|.::.:|||||||||..||.:..|||.:||.:::..:|..|...||.|......::|..|:||
Human   195 NTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVP 259

  Fly   263 YPRIHYPLINYAPLVPISHSQFVNMSTAQLTGQCFQMSNQMVRCNPSHGKYMASVLLYRGDIAPN 327
            :||:|:.:..:|||......|:..::..:||.|.|...|.|..|:|.||:|:....::||.::..
Human   260 FPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMK 324

  Fly   328 EINTALENIKRNRSFRFVDWSPTGFKIGVSPMPPYYVPGGDLAPTNRACVAISNNTNIRIAWCRL 392
            |::..:.|::...|..||:|.|...|..|..:||   .|..::.|     .|.|:|.|:..:.|:
Human   325 EVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPP---RGLKMSAT-----FIGNSTAIQELFKRI 381

  Fly   393 VNKFDKLYQRRAFVYHYVGEGLEEGNFNEASENICQLVHDYLEV-DASAPTSRRDSDPEEDS 453
            ..:|..:::|:||::.|.|||::|..|.||..|:..||.:|.:. ||   |:..:.:.||::
Human   382 SEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDA---TAEEEGEFEEEA 440

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.