Protein Alignment Rim and RIMS2

DIOPT Version :10

• Sequence 1: NP_001247163.1
• Gene: Rim / 42150
• FlyBaseID: FBgn0053547
• Length: 2798
• Species: Drosophila melanogaster
• Sequence 2: XP_011515697.1
• Gene: RIMS2 / 9699
• HGNCID: 17283
• Length: 1710
• Species: Homo sapiens
• Alignment Length: 2927
• Identity: 634/2927 - (21%)
• Similarity: 917/2927 - (31%)
• Gaps: 1384/2927 - (47%)

  Fly     3 EMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQD---------------EVVT------- 45
            |||||||||..||..|..|:.|||:||||:..:::.|::               |:|.
Human    25 EMPDLSHLTEEERKIILAVMDRQKKEEEKEQSVLKVKEEHKPQLTQWFPFSGITELVNNVLQPQQ 89

  Fly    46 -----------LEMQIRQRSEQQKKAGVEL--------DA-TCHICLKTKFADGVGHICHYCNIR 90
                       |..|.....||.||.|.|.        || ||.||.|||||||.||.|.||..:
Human    90 KQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICHKTKFADGCGHNCSYCQTK 154

  Fly    91 CCARCGGKVTLRSNK----VIWVCILCRKKQELLSKTGQWI----NKTAAQQDGFIRRIEPDGSS 147
            .||||||:|:|||||    |:|||.||||:||:|:|:|.|.    :.|..|.|..:.|
Human   155 FCARCGGRVSLRSNKEDKVVMWVCNLCRKQQEILTKSGAWFYNSGSNTPQQPDQKVLR------- 212

  Fly   148 DISQHPIVDPHDTTDKRPKL-ERTRSAAEKENL---PMQRAGSM-LRRQYSQQEQPTNRRLSASD 207
                 .:.:.....:|:||| |:|:......:|   .::::.|. |.||:|.:.....:...|||
Human   213 -----GLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGLTRQHSIKNGSGVKHHIASD 272

  Fly   208 SGMD------------------PVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSG 254
            ...|                  |.:|..|..::.|:::|         :....|.......|||.
Human   273 IASDRKTSSELLNSKIISRKRSPSVSRDQNRRYDQREER---------EEYSQYATSDTAMPRSP 328

  Fly   255 GAYPD----DDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPS 315
            ..|.|    .:|::|:                   ...|.....|.::..:|.:::::..:...|
Human   329 SDYADRRSQHEPQFYE-------------------DSDHLSYRDSNRRSHRHSKEYIVDDEDVES 374

  Fly   316 PQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHA--QIHQQPQQHPHPHSQQQQHHQQM 378
                                 :.::::|:.:::.|..|.:  .:.:.|.: |.|:.:|.:.|.::
Human   375 ---------------------RDEYERQRREEEYQSRYRSDPNLARYPVK-PQPYEEQMRIHAEV 417

  Fly   379 ---QHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSS-AYSQQQQQQQRRALAGSQYASQQQRS 439
               :|:...|               :::::.....||. :..:..:..::|:::..:.|.:.|||
Human   418 SRARHERRHS---------------DVSLANADLEDSRISMLRMDRPSRQRSISERRAAMENQRS 467

  Fly   440 FSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGG 504
            :|      ..:...|||.      |.|               .||:.|.
Human   468 YS------MERTREAQGP------SSY---------------AQRTTNH---------------- 489

  Fly   505 ADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGG 569
                  |..|.|                 |..|   |:.|.   |:::.:||.:.:|
Human   490 ------SPPTPR-----------------RSPL---PIDRP---DLRRTDSLRKQHH-------- 517

  Fly   570 AGVGPGGAGGGGAAGAYRRA--PPLAAAGGGGSSSSSTTSSSYYPQSKP----------QIVIGP 622
              :.|        :.|.|:.  ..:.......|.||..:.|...|..||          ||.:
Human   518 --LDP--------SSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQISL-- 570

  Fly   623 GSGYDRGSGSMASMASAAAATAA-DAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPAT 686
                   |.|...:||....|:. |.:.::...|::|......|                    .
Human   571 -------SSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKR--------------------K 608

  Fly   687 SSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSL 751
            :|..:...||...:||: |:.:.|..|..|..:
Human   609 TSEQAVLSDSNTRSERQ-KEMMYFGGHSLEEDL-------------------------------- 640

  Fly   752 DAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIG 816
                    :||          :...||||:||.|:.|.:|:.:..|  |:||.||.|.|..||||
Human   641 --------EWS----------EPQIKDSGVDTCSSTTLNEEHSHSD--KHPVTWQPSKDGDRLIG 685

  Fly   817 HMILRKYY-------DGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVA 874
            .::|.|..       |...:|||||.||:...:|..               | |.:.|||:||:|
Human   686 RILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRL---------------C-AFITKVKKGSLA 734

  Fly   875 DLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPI 939
            |..|.:|||||:||||||.|...:.:|||:||.||:.:.||||:||||||
Human   735 DTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIG--------------- 784

  Fly   940 SGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITS 1004
                     .:|....|.   |:.|.||.:.         :..:|          .|:||:.:||
Human   785 ---------DIPRIPDST---HAQLESSSSS---------FESQK----------MDRPSISVTS 818

  Fly  1005 PGSP----DIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAP 1065
            |.||    |:...:|  |.:|...|.:|
Human   819 PMSPGMLRDVPQFLS--GQLSSQSLSRR------------------------------------- 844

  Fly  1066 ASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVG 1130
                                                                             
Human   845 ----------------------------------------------------------------- 844

  Fly  1131 GGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPD 1195
                       ||..:|   |:|:||.:|:...|||||::.|..|..|:.|..||||.|::.|||
Human   845 -----------TTPFVP---RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPD 895

  Fly  1196 RSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLA 1258
            ||.|:|||||||..|.||:|.|||:||.:.|.:...|:||:||||.  ||...::|:||::|:|.
Human   896 RSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELE 960

  Fly  1259 HHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMT 1323
            ..:||||..||:||.|            ||..|   |..|.||.....:|.....|
Human   961 TALLDDEPHWYKLQTH------------DVSSL---PLPHPSPYMPRRQLHGESPT--------- 1001

  Fly  1324 PGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATG 1388
                                    ||.:|.      ||::.....||....|||        ...
Human  1002 ------------------------RRLQRS------KRISDSEVSDYDCDDGIG--------VVS 1028

  Fly  1389 YYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPD 1453
            .||..|.:...|.:......:|  |:..:||...|...|.|..        ||.||   |:.||.
Human  1029 DYRHDGRDLQSSTLSVPEQVMS--SNHCSPSGSPHRVDVIGRT--------RSWSP---SVPPPQ 1080

  Fly  1454 DRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQT 1518
            .|                 :|.||..|                   |.|.||
Human  1081 SR-----------------NVEQGLRG-------------------TRTMTG------------- 1096

  Fly  1519 SRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARM 1583
                                                            ||..:|..|.|    |:
Human  1097 ------------------------------------------------HYNTISRMDRH----RV 1109

  Fly  1584 RPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGA 1648
            ...| .|||:|
Human  1110 MDDH-YSPDRD------------------------------------------------------ 1119

  Fly  1649 GGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIG 1713
                                   .||:                          |||..|
Human  1120 -----------------------RDCE--------------------------AADRQP------ 1129

  Fly  1714 IQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTI 1778
                                                                             
Human  1130 ----------------------------------------------------------------- 1129

  Fly  1779 YPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSL 1843
            |...||...:|.::.|..           :.:....|.||..||.      |......|..||..
Human  1130 YHRSRSTEQRPLLERTTT-----------RSRSTERPDTNLMRSM------PSLMTGRSAPPSPA 1177

  Fly  1844 VGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEP 1908
            :         |.||.:.||...                                          .
Human  1178 L---------SRSHPRTGSVQT------------------------------------------S 1191

  Fly  1909 PSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPP-------T 1966
            |||                                   ||.|.||.|   ..|..||       |
Human  1192 PSS-----------------------------------TPVAGRRGR---QLPQLPPKGTLDRST 1218

  Fly  1967 QSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRR 2031
            ..:...:||:.         |::.|....|   .|:||:            ||...:...|...
Human  1219 MDIEERNRQMK---------INKYKQVAGS---DPRLEQ------------DYHSKYRSGWDPH- 1258

  Fly  2032 IRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTD 2096
             |..|.|...|.|         |..|..:|:||                     ..|.|.|..|
Human  1259 -RGADNVSTKSSD---------SDVSDISAVSR---------------------TSSASRFSST- 1291

  Fly  2097 DKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRN 2161
                                                 ::||:..:|....|...|..
Human  1292 -------------------------------------SYMSVQSERPGGNKKIRPKG-------- 1311

  Fly  2162 LPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSV 2226
                                            :|:|...|
Human  1312 --------------------------------IEEGGKEG------------------------- 1319

  Fly  2227 SQSHNQQLQQQQQLQQQSV--RQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGG 2289
             ..|.:.:.::::::::.:  .:||||          .::...|..:...|
Human  1320 -DKHEEIVHEKEEVKEERINENEKGKE----------IAKTCNKEKNRESG-------------- 1359

  Fly  2290 TNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQ 2354
                             ..::.|.:|.........||.                     |..::.
Human  1360 -----------------DEEKTQDIHEQGKEKEQWNKE---------------------DLQRRF 1386

  Fly  2355 SQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNE 2419
            ||..                     |:..||...:.....:..|.|.:|:
Human  1387 SQDD---------------------TSVFTSKMQSRQMGISGKNMTKSTS--------------- 1415

  Fly  2420 PNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAG 2484
                                                 :..|....:|:
Human  1416 -------------------------------------ISGDMCSLEKN----------------- 1426

  Fly  2485 AEDKVDGSLSDTANDRKKGGGVDQERSPKGGS-----GMGKKSNSTSQLSAT---GRKRRMGFGK 2541
                 |||.||||.......| .:.||..|..     |:.:||.|.||||.|   |:|.|.
Human  1427 -----DGSQSDTAVGTLGTSG-KKRRSSLGAKMVAIVGLSRKSRSASQLSQTEAGGKKLRS---- 1481

  Fly  2542 KGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQF 2606
                  ||.||.|.             ||.|.:              ...::|.:|.|..
Human  1482 ------TVQRSTET-------------GLAVEM--------------RNWMTRQASREST----- 1508

  Fly  2607 FGDG------AGGERFSPSLR--NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCL 2663
              ||      :.|....|.:|  :|...::|:|||||.||||||.|..|::||||:.:..:||.|
Human  1509 --DGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQL 1571

  Fly  2664 EVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCI 2728
            |||:||||||..|..||.||||||||||:....|:.|.||..||:||:|||||.|.|::|..|.:
Human  1572 EVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGKV 1636

  Fly  2729 LQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASL 2793
            |||.|||||||::.|.|||||||:||:|.|||:||||:|||..:|||. ||...| :||:|.:||
Human  1637 LQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVD-PTLAPL-TRRASQSSL 1699

  Fly  2794 DS 2795
            :|
Human  1700 ES 1701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:473978	69/163 (42%)
		PDZ_RIM-like	813..920	CDD:467198	48/113 (42%)
		C2A_RIM1alpha	1148..1272	CDD:175997	62/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	89/141 (63%)
RIMS2	XP_011515697.1	PHD_SF	30..198	CDD:473978	70/167 (42%)
		PDZ_RIM-like	681..780	CDD:467198	48/114 (42%)
		C2A_RIM1alpha	851..974	CDD:175997	62/122 (51%)
		C2B_RIM1alpha	1541..1686	CDD:175994	91/145 (63%)