DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and Rims1

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	XP_017452146.2	Gene:	Rims1 / 84556	RGDID:	620000	Length:	1642	Species:	Rattus norvegicus

Alignment Length:	2928	Identity:	598/2928 - (20%)
Similarity:	864/2928 - (29%)	Gaps:	1446/2928 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMR---------------------------- 37
            |.|:|||||||..||..|..|:.|||:||||:..:::
  Rat    19 MQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLN 83

  Fly    38 --------RK-------QDEVVTLEMQIRQRSEQQKKAGVEL---------DA-TCHICLKTKFA 77
                    ||       .:....|..|.....||.:|.|.|.         || ||.||.|||||
  Rat    84 IFRCVCVPRKPSSEEGGPERDWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFA 148

  Fly    78 DGVGHICHYCNIRCCARCGGKVTLRSNK----VIWVCILCRKKQELLSKTGQWINKTAAQ---QD 135
            ||.||:|.||..:.||||||:|:||||.    |:|||.||||:||:|:|:|.|...:..|   ||
  Rat   149 DGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQPSQD 213

  Fly   136 GFIRRIEPDGSSDISQHPIVDPHDTTDKRPKL-ERTRSAAEKENLPMQRAGSMLRRQYSQQE--- 196
            |.:........|::.:          :|:.:| ||:||     ..|:..|.      .|.|:
  Rat   214 GTLSDTATGAGSEVPR----------EKKARLQERSRS-----QTPLSTAA------VSSQDTAT 257

  Fly   197 --QPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPD 259
              .|.:|...|         .|.||....:|:|.:|.:...|::.::..|:.:|.  ..||
  Rat   258 PGAPLDRNKGA---------EPSQQALGPEQKQASRSRSEPPRERKKAPGLSEQN--GKGG---- 307

  Fly   260 DDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQ 324
                         .:........|.|||   .:..:.:::.:.:::....::.|  .|.:|.:.:
  Rat   308 -------------QKSERKRVPKSVVQP---GEGIADERERKERRETRRLEKGR--SQDYSDRPE 354

  Fly   325 QQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQM 389
            ::..      .|..:.|:|:.:::.|..|                              :|.|.:
  Rat   355 KRDN------GRVAEDQKQRKEEEYQTRY------------------------------RSDPNL 383

  Fly   390 GGYQ-KPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLA 453
            ..|. |.||                      ::||.|..|....|..::|   .|:....|...|
  Rat   384 ARYPVKAPP----------------------EEQQMRMHARVSRARHERR---HSDVALPHTEAA 423

  Fly   454 AQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLY 518
            |......|||.                                             .:.||.|:.
  Rat   424 AAAPAEATAGK---------------------------------------------RAPATARVS 443

  Fly   519 ASADQRDR---YELQLQH---------------RERLEQYPLTRTARLDVQQRNSLNRSNHERQF 565
            .....|.|   .:...:|               ..|:.: ||.:..|||......|.::..|:
  Rat   444 PPESPRARAPAAQPPTEHGPPPPRPAPGPAEPPEPRVPE-PLRKQGRLDPGSAVLLRKAKREK-- 505

  Fly   566 SGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQ-SKPQIVIGPGSGYDRG 629
                            |....|           ..|.||..|.|..|. .||.   .|..|..|.
  Rat   506 ----------------AESMLR-----------NDSLSSDQSESVRPSPPKPH---RPKRGGKRR 540

  Fly   630 SGSMASMASAAAAT-----AADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSS 689
            ..|::|......:|     ..|.:.::...|::|.|                 ..||.:|||
  Rat   541 QMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDL-----------------DYYWLDPAT--- 585

  Fly   690 SSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAV 754
                                  .|..|.|.::|
  Rat   586 ----------------------WHSRETSPISS-------------------------------- 596

  Fly   755 GVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMI 819
                                                          :||.||.|.:..||||.:|
  Rat   597 ----------------------------------------------HPVTWQPSKEGDRLIGRVI 615

  Fly   820 LRKY----YDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRI 880
            |.|.    .:...:|||||.||:....                |..||.:.|||:||:||:.|.:
  Rat   616 LNKRTTMPKESGALLGLKVVGGKMTDL----------------GRLGAFITKVKKGSLADVVGHL 664

  Fly   881 RPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGG 945
            |.|||:|||||:.|...:.:|||:||.||:.:.|||:|||||||
  Rat   665 RAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIG--------------------- 708

  Fly   946 SANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDI 1010
               .:|....|::.|....:||.....:                      ::||:.:.||.||
  Rat   709 ---DIPRIPESSHPPLESSSSSFESQKM----------------------ERPSISVISPTSP-- 746

  Fly  1011 HTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHAS 1075

  Rat   747 ----------------------------------------------------------------- 746

  Fly  1076 ASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSG 1140
             .|...||
  Rat   747 -GALKDAP--------------------------------------------------------- 753

  Fly  1141 TTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTK 1205
               |.:|  |:|.:||.||:...||||.::.||.|..|..|..||||.|::.|||||.|||||||
  Rat   754 ---QVLP--GQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRRTK 813

  Fly  1206 TVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLAHHILDDEAEW 1268
            ||....||:|.||||||.:.|.|...|:||:|:||.  |:...::|:||::|:|...:||||..|
  Rat   814 TVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEPHW 878

  Fly  1269 YQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGS 1333
            |:||.|.::|..|.....      ..|..|:...|:..:|..|...||.||.
  Rat   879 YKLQTHDESSLPLPQPSP------FMPRRHIHGESSSKKLQRSQRISDSDIS------------- 924

  Fly  1334 SASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGV 1398
                                               ||....|||..
  Rat   925 -----------------------------------DYEVDDGIGVV------------------- 935

  Fly  1399 GSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLP 1463
                                                |..|||
  Rat   936 ------------------------------------PPVGYR----------------------- 941

  Fly  1464 VHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRL 1528
                                  |||.     :|::.|.|            ||:..|:.
  Rat   942 ----------------------ASAR-----ESKATTLT------------VPEQQRTT------ 961

  Fly  1529 GQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDK 1593
                           .||:|                                       |:||.:
  Rat   962 ---------------HHRSR---------------------------------------SVSPHR 972

  Fly  1594 DFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRL 1658
                  ||
  Rat   973 ------GD--------------------------------------------------------- 974

  Fly  1659 HHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVT 1723
               :.||
  Rat   975 ---DQGR---------------------------------------------------------- 978

  Fly  1724 DANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLK 1788
                                                  |...||..|....:|.|:|.|||..
  Rat   979 --------------------------------------PRSRLPNVPLQRSLDEIHPTRRSRS-- 1003

  Fly  1789 PNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDK 1853
                                                     |..|...|.:|:       ||:.:
  Rat  1004 -----------------------------------------PTRHHDASRSPA-------DHRSR 1020

  Fly  1854 SCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGE 1918
                                                       |.:.|   |...|.|:..|
  Rat  1021 -------------------------------------------HVESQ---YSSEPDSELLM--- 1036

  Fly  1919 CVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVA 1983
                                        .|.| :|.|...:.......|..|..:|..|.:.|
  Rat  1037 ----------------------------LPRA-KRGRSAESLHMTSELQPSLDRARSASTNCL-- 1070

  Fly  1984 AVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYP 2048
                     :|.:.|..|:.||.|     .|.|||          |||        |:|......
  Rat  1071 ---------RPDTSLHSPERERGR-----WSPSLD----------RRR--------PASPRIQIQ 1103

  Fly  2049 HSNP----YSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVG 2109
            |::|    :|..|...::.         :||..|...||:
  Rat  1104 HASPENDRHSRKSERCSIQ---------KQSRKGTASDAD------------------------- 1134

  Fly  2110 WTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNF 2174
               |.:.|.|.|     ||.|.||        .|.|..:.|            .||..::::.
  Rat  1135 ---RVLPPCLSR-----RGYATPR--------ATDQPVVRG------------KHPTRSRSSE-- 1169

  Fly  2175 SPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHH----NSQASSVSVSQSHNQQLQ 2235
                                           |::..|..|.||    .|...|..::::|.|...
  Rat  1170 -------------------------------HSSVRTLCSMHHLAPGGSAPPSPLLTRTHRQGSP 1203

  Fly  2236 QQ-------------QQLQQQSVRQKGKEGTTAI----SGSMMASEQLTKSSSGSGGATSAAAAG 2283
            .|             :||.|..||....|..:.:    :..|.......|.::|||.:
  Rat  1204 TQSPPADTSFGSRRGRQLPQVPVRSGSIEQASLVVEERTRQMKMKVHRFKQTTGSGSS------- 1261

  Fly  2284 HLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTL 2348
                                     |:......|..|::.:..|
  Rat  1262 -------------------------QELDHEQYSKYNIHKDQYR--------------------- 1280

  Fly  2349 DATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTT 2413
                             :|.|         .:..::.|:.::.:..:.|::|:..::    |:..
  Rat  1281 -----------------SCDN---------ASAKSSDSDVSDVSAISRASSTSRLSS----TSFM 1315

  Fly  2414 TNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSK 2478
            :..:..|....::.|.....                                 .:.|.......|
  Rat  1316 SEQSERPRGRISSFTPKMQG---------------------------------RRMGTSGRAIIK 1347

  Fly  2479 SAEGAG---AEDKVDGSLSDTANDRKKGGGVDQER--SPKGGSGMGKKSNSTSQLSAT--GRKRR 2536
            |...:|   ..::.|||.||||......||..:..  |.|..:.:.::|.||||||.|  |.|
  Rat  1348 STSVSGEIYTLERNDGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHK-- 1410

  Fly  2537 MGFGKKGKNSFTVHRSEEV-LPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEV 2600
                   |...|:.||.|. :..::.:.:|..                         ||.|:.
  Rat  1411 -------KLKSTIQRSTETGMAAEMRKMVRQP-------------------------SRESTD-- 1441

  Fly  2601 DAIEQFFGDG---AGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGC 2662
            .:|..:..:|   ..|.|..|    |...::|:|||||.||||||.|..|::||||:.:..:||.
  Rat  1442 GSINSYSSEGNLIFPGVRVGP----DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQ 1502

  Fly  2663 LEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGC 2727
            |||||||||.|.||..||..|||||||||:....|:.|.||..||:||||||||.|||.:|..|.
  Rat  1503 LEVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGK 1567

  Fly  2728 ILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIAS 2792
            :||:.|||||||::.|.|||||||:|::|:||::||||||||..:|||. ||...| :||:|.:|
  Rat  1568 VLQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVD-PTLAPL-TRRASQSS 1630

  Fly  2793 LDS 2795
            |:|
  Rat  1631 LES 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	66/174 (38%)
		PDZ_signaling	817..919	CDD:238492	41/105 (39%)
		C2A_RIM1alpha	1148..1272	CDD:175997	63/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	89/141 (63%)
Rims1	XP_017452146.2	FYVE_like_SF	<154..209	CDD:333710	28/54 (52%)
		DUF601	214..>316	CDD:282493	26/150 (17%)
		PLN03237	<433..550	CDD:215641	30/194 (15%)
		PDZ_signaling	618..703	CDD:238492	39/100 (39%)
		C2A_RIM1alpha	756..882	CDD:175997	64/127 (50%)
		PHA03307	887..>1241	CDD:223039	124/1003 (12%)
		C2B_RIM1alpha	1473..1618	CDD:175994	91/145 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337254
Domainoid	1	1.000	144	1.000	Domainoid score	I4482
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	622	1.000	Inparanoid score	I838
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm44737
orthoMCL	1	0.900	-	-		OOG6_103451
Panther	1	1.100	-	-	LDO	PTHR12157
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2115
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900