DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rim and Rims3

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	NP_075220.2	Gene:	Rims3 / 65025	RGDID:	628762	Length:	307	Species:	Rattus norvegicus

Alignment Length:	333	Identity:	128/333 - (38%)
Similarity:	177/333 - (53%)	Gaps:	49/333 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  2476 GSKSAEGAGAEDKVDGSLS---DTANDRKKGGGVDQERSPKGGSGMGKK----------SNSTSQ 2527
            |......|||...|..|.|   :....::.|||.....:.|..|.:|.|          |.||.|
  Rat     4 GEPGPASAGASRNVVRSSSISGEICGSQQAGGGAGTTTAKKRRSSLGAKMVAIVGLTQWSKSTLQ 68

  Fly  2528 LSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGL 2592
            |     .:..|..||.:::  :.||.|.   .|..|:|:    .|:..|:..:..||
  Rat    69 L-----PQPEGATKKLRSN--IRRSTET---GIAVEMRS----RVTRQGSRESTDGS-------- 111

  Fly  2593 SRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLC 2657
            :..:|||            |...|...|..:...::|:|||||.|:||||.|..|.:||:.:::.
  Rat   112 TNSNSSE------------GTFIFPTRLGAESQFSDFLDGLGPAQIVGRQTLATPPMGDVHIAIM 164

  Fly  2658 HQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQ 2722
            .:.|.||||||.||||..|..||.|||.|:|.||:....||.|.||..|::|.||||||.|:|.:
  Rat   165 DRSGQLEVEVIEARGLTPKPGSKSLPATYIKAYLLENGACVAKKKTKVAKKTCDPLYQQALLFDE 229

  Fly  2723 SYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRR 2787
            ...|.:||:.|||||||::.|.|||:||||||:|:||.:|.||||||.|:|:..  :.:|..:||
  Rat   230 GPQGKVLQVIVWGDYGRMDHKCFMGMAQIMLDELDLSAVVTGWYKLFPTSSVAD--STLGSLTRR 292

  Fly  2788 SSIASLDS 2795
            .|.:||:|
  Rat   293 LSQSSLES 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600
		PDZ_signaling	817..919	CDD:238492
		C2A_RIM1alpha	1148..1272	CDD:175997
		C2B_RIM1alpha	2633..2775	CDD:175994	80/141 (57%)
Rims3	NP_075220.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..120		12/60 (20%)
Rims3	NP_075220.2	C2	140..285	CDD:417471	80/146 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337255
Domainoid	1	1.000	144	1.000	Domainoid score	I4482
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm44737
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12157
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.950