DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and rims1b

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	XP_021332389.1	Gene:	rims1b / 568486	ZFINID:	ZDB-GENE-101223-4	Length:	1602	Species:	Danio rerio

Alignment Length:	2878	Identity:	616/2878 - (21%)
Similarity:	884/2878 - (30%)	Gaps:	1391/2878 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVEL- 64
            |.:||||||||..||..|..|::||::||||:..:::       ||..|.....||.:|.|.|.
Zfish    20 MPDMPDLSHLTEEERKVIMAVMVRQREEEEKEQAMLK-------TLHQQFESYKEQVRKIGAETK 77

  Fly    65 --------DA-TCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSN-----------KVIWV 109
                    || ||.||.|||||||.||:|.||..:.||||||:|:||||           :|:||
Zfish    78 RQQAVHKDDAPTCGICRKTKFADGCGHLCSYCQTKFCARCGGRVSLRSNNEDKVCLIGKDRVMWV 142

  Fly   110 CILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERTRSAA 174
            |.||||:||:|:|:|:|.:.            .|.|.......|:        ..|:||:.|...
Zfish   143 CNLCRKQQEILTKSGEWFSS------------GPGGRPLSVGSPL--------SGPELEKERKLR 187

  Fly   175 EKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQA 239
            .:..:|                       .|:|: :.|...||...:.......:|.:...|::.
Zfish   188 SRSQVP-----------------------GANDT-LLPNAGPGDHPKGADTMPASRSRSEPPREK 228

  Fly   240 QQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTP----------QSH 294
            ::...|.:|.....|           :||     |:.......||......|          :.|
Zfish   229 RRPVSMHEQNGKVIG-----------RGE-----RRRAPARLSSQASEDRAPGENRDGRRLEKDH 277

  Fly   295 SQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQ 359
            ||:....|             |::..:|::::         |::|.:::::|.:.
Zfish   278 SQEDDPTH-------------PERRRRQEEEE---------RERQRREEEYQTRY---------- 310

  Fly   360 QPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQR 424
                                    :|.|.:..|...|                    |:::|:.|
Zfish   311 ------------------------RSDPNLARYPVKP--------------------QKEEQEMR 331

  Fly   425 RALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNER 489
                       .....|...:|..|..||                                :||.
Zfish   332 -----------MHAKVSKMRQERHHSDLA--------------------------------INEV 353

  Fly   490 DLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRN 554
            .|:..||...|       ..:|.  ||:   |...||..|...||    .|.:.||
Zfish   354 GLMQDGGEAAG-------NRISR--QRV---ASNEDRKALLENHR----AYSVDRT--------- 393

  Fly   555 SLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQI- 618
                             || ||.||.|:          ...|.||                ||:
Zfish   394 -----------------VG-GGVGGQGS----------LKQGHGG----------------PQMG 414

  Fly   619 VIGP---GSGYDRG------SGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVS 674
            :.||   ..|.|.|      .||.|.:..|....||:...:                   .||:|
Zfish   415 LTGPPDLRDGQDWGPKGHLEPGSAAFLHRAKREKAAEIMRK-------------------DSSLS 460

  Fly   675 STEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSL--PPVTAILPSTAV 737
            |.:                                            |.||  ||..|..|...:
Zfish   461 SDQ--------------------------------------------SESLRPPPPRAYRPKRGL 481

  Fly   738 DVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSED------SNRG 796
            :                            :||.|..|:.::.|  ::..:||.||      |.:|
Zfish   482 N----------------------------KRQMSISSSEEEGG--STPEYTSCEDVEIESVSEKG 516

  Fly   797 DGP---------KNPVNWQTSADNTRLIGHMILRKY----YDGEDILGLKVNGGQPLATGGSVSG 848
            |..         .:||:||.|.:...|||.:.|.|.    .:...:|||||.||:
Zfish   517 DWDCHPLDPTVWHHPVSWQPSKEGDHLIGRITLSKRSTMPREAGSLLGLKVVGGK---------- 571

  Fly   849 AGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDA 913
                  :...|..||.:.|||:||:||:.|.:|.|||:|:|||:.|...:..|||:||.||:...
Zfish   572 ------MTESGRLGAFITKVKKGSLADIVGHLRAGDEVLQWNGKALPGATKKEVYNIILESQSAP 630

  Fly   914 QVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGG 978
            |||::||||||                         ...|..|.||
Zfish   631 QVEIVVSRPIG-------------------------CIQRILSKNF------------------- 651

  Fly   979 RYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLG-PSHS 1042
                    ..:....:::.|.:    ||:.  |..:...||.|         :.::|::. ||
Zfish   652 --------LKKVYRAYQETPRL----PGTS--HPPLESTGSSS---------IDESQKMDRPS-- 691

  Fly  1043 THSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQ 1107
                             .||.:|.|               ||.|...
Zfish   692 -----------------ISVMSPTS---------------PGMLRDL------------------ 706

  Fly  1108 HPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCA 1172
                                                 |:.:.|:|.:||.||:...||||.::.|
Zfish   707 -------------------------------------PLVLPGQLSVKLWYDKVGHQLIVNVLQA 734

  Fly  1173 TGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVT 1237
            ..|..|..|..||||.|::.|||||.|||||||||..:.||:|.|||:||.:.|.|...|:||:|
Zfish   735 RELPPRPDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKSAEPKWNQTFLYSHVHRRDFRERMLEIT 799

  Fly  1238 LWDYVR--YGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLS 1300
            :||..|  ...:||:||::|:|...:|||:|.||:.|.|            ||..|.|
Zfish   800 VWDQPRAQEEESDFLGEILIELETALLDDQAHWYKFQTH------------DVSSLPL------- 845

  Fly  1301 PPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGM 1365
                                              ..|.|.|     .||.....||.  |::
Zfish   846 ----------------------------------PQPSPCL-----PRRHVHGDSPS--KKL--- 866

  Fly  1366 VARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGA 1430
                                                         ||||....:|
Zfish   867 ---------------------------------------------QRSHRIIETD---------- 876

  Fly  1431 ASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQ 1495
                                     |.|                     |::..:::|.:..|.:
Zfish   877 -------------------------YDD---------------------GITVVSSAAERTSRDR 895

  Fly  1496 SRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTR-QPHHQATYRST 1559
            .||:|.|            ||:  |.|.::.|      .|..|..|..:.|.| :|.|....||.
Zfish   896 ERSSTLT------------VPE--RQAAIQHR------SRSVSPHREDQCRARSRPAHIPMQRSL 940

  Fly  1560 GMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRT 1624
            ......||:   |.|..|..|:....|.            ||||.|         :|..||
Zfish   941 DEIHQNRHH---SYSPSHYHDSHQEHRS------------GDSDYE---------YSEDSE---- 977

  Fly  1625 SRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLE 1689
                                          .|.:|.|..|               |.|      |
Zfish   978 ------------------------------VLEMHRSIRG---------------GSA------E 991

  Fly  1690 QLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLH 1754
            .|...::||
Zfish   992 CLHTNRKLA-------------------------------------------------------- 1000

  Fly  1755 PHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNF 1819
                                       |..|.|.|.         :|||.:
Zfish  1001 ---------------------------RHCNTLPPK---------MPLLVN-------------- 1015

  Fly  1820 FRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGA 1884
                   |:|...:..|.
Zfish  1016 -------GIHKDIYSSTL----------------------------------------------- 1026

  Fly  1885 CQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPN 1949
               |.||....|
Zfish  1027 ---PACLKSKAP----------------------------------------------------- 1035

  Fly  1950 AHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQS 2014
              ||.......|.....|.:||.:.::|...|                  :|.|:|
Zfish  1036 --RRTERDEVVPLSAIPQRILRFTDEVSSGDL------------------QPSLDR--------- 1071

  Fly  2015 RSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNI-RQSYMG 2078
                     .:|.....:|.|     ||...|..||.                   |: |.|...
Zfish  1072 ---------VRSASTTCLRPE-----SSFHSPERHSG-------------------NLDRPSCQI 1103

  Fly  2079 ANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRT 2143
            ||..                    |.|.|     |....|:.||:.|:|         ...|:..
Zfish  1104 ANKK--------------------TIDGD-----RLQPTSILRGSRRRR---------ETPLRPF 1134

  Fly  2144 SQQKLYG--PAAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAH 2206
            .|..|.|  |.:|  :..|:|||      ..::||              ||
Zfish  1135 GQTSLGGSCPNSP--RADRDLPH------GGHYSP--------------AG-------------- 1163

  Fly  2207 NTTSTHNSNHHNSQ--ASSVSVSQSH------NQQLQQQQQLQQQSVRQKGKEGTTAISGSMMAS 2263
             |||.........|  |.|.|:.|..      |..|..:::.:|..:|.
Zfish  1164 -TTSLGRRGRQLPQLPAKSSSIEQGRIPEEKPNSALAVEERARQLQMRV---------------- 1211

  Fly  2264 EQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRA 2328
                                |....|::||:|.     :|:.....::........:.:|.:.|:
Zfish  1212 --------------------HSYRPGSSANSAH-----DPEAELKNRRDMYKDQRRSCDNMSARS 1251

  Fly  2329 PSSTPQQNTNTINDANNLT-LDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAA 2392
             |.:...:.:.|:.|::.: |.||...|.|.:             .|...::....|||..:...
Zfish  1252 -SDSDMSDVSAISHASSASRLSATSYMSIQSE-------------RPHGRISRQVRTSSGRSMLK 1302

  Fly  2393 TTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAML 2457
            :|:.:...|.:
Zfish  1303 STSVSGDINTS------------------------------------------------------ 1313

  Fly  2458 DDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGM---- 2518
                                         ::.|||.||||.. ..|.|..:.||......:
Zfish  1314 -----------------------------ERTDGSQSDTALG-TVGTGAKKRRSSLNARFVAIVG 1348

  Fly  2519 GKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGG 2583
            .::|.||||:|.|....:...|.:|    |:.||:|.             |:.|.|
Zfish  1349 NRRSRSTSQISQTEASNKKSKGSQG----TIQRSQET-------------GMAVEL--------- 1387

  Fly  2584 SGGAGGGGLSRGSSSEVD--AIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGA 2646
                 ...:||..|.|.:  :...:..:|:   ...|::|.:...::|:|||||.||||||.|..
Zfish  1388 -----QRNMSRQPSRESNNGSTNSYNSEGS---PIFPAVRVETQFSDFLDGLGPAQLVGRQTLAT 1444

  Fly  2647 PSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLD 2711
            |::||||:.:.::||.|||||||||||.||..||.||||||||||:.....|.|.||..||:|||
Zfish  1445 PAIGDIQIGMVNKKGQLEVEVIRARGLIQKPGSKSLPAPYVKVYLLHNGAYVAKKKTKIARKTLD 1509

  Fly  2712 PLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVS 2776
            |||||.|.|::|..|.:||:.|||||||::.|.|||||||:|::|:||:.||||||||..:|||.
Zfish  1510 PLYQQTLQFEESPQGKVLQVIVWGDYGRMDHKSFMGVAQILLEELDLSSNVIGWYKLFPPSSLVD 1574

  Fly  2777 CPTNIGLGSRRSSIASLD 2794
             ||...| :||:|.:|||
Zfish  1575 -PTLASL-TRRASQSSLD 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	64/138 (46%)
		PDZ_signaling	817..919	CDD:238492	39/105 (37%)
		C2A_RIM1alpha	1148..1272	CDD:175997	62/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	90/141 (64%)
rims1b	XP_021332389.1	PHD_SF	27..160	CDD:328929	64/139 (46%)
		PDZ_signaling	554..636	CDD:238492	37/97 (38%)
		C2A_RIM1alpha	710..836	CDD:175997	62/125 (50%)
		C2B_RIM1alpha	1431..1576	CDD:175994	92/145 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576382
Domainoid	1	1.000	148	1.000	Domainoid score	I4404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	584	1.000	Inparanoid score	I968
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm24270
orthoMCL	1	0.900	-	-		OOG6_103451
Panther	1	1.100	-	-	O	PTHR12157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2115
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900