Protein Alignment Rim and rims2b

DIOPT Version :9

• Sequence 1: NP_001247163.1
• Gene: Rim / 42150
• FlyBaseID: FBgn0053547
• Length: 2798
• Species: Drosophila melanogaster
• Sequence 2: XP_021323970.1
• Gene: rims2b / 563393
• ZFINID: ZDB-GENE-060503-893
• Length: 1846
• Species: Danio rerio
• Alignment Length: 2896
• Identity: 688/2896 - (23%)
• Similarity: 982/2896 - (33%)
• Gaps: 1194/2896 - (41%)

  Fly     3 EMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRR--KQD---------------EVVT----- 45
            :||||||||..||..|.:|:.|||:||||:...::.  .:|               |:|:
Zfish    20 DMPDLSHLTEEERKIILSVMDRQKKEEEKEQSTLKEAPSEDTKPHPAQWNPFSGITELVSNVLQP 84

  Fly    46 -------------LEMQIRQRSEQQKKAGVEL---------DATCHICLKTKFADGVGHICHYCN 88
                         |..|.:...:|.||.|.|.         ..||.||.|||||||.||:|.||.
Zfish    85 QSKSPSEEEPKPKLHQQFKMYKDQVKKIGDEAPKNPEQKGDSPTCGICHKTKFADGCGHVCSYCQ 149

  Fly    89 IRCCARCGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDISQHP 153
            .:.||||||:|:||||||:|||.||||:||:|:|:|.|...            .|:||
Zfish   150 TKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGAWFYS------------GPEGS------- 195

  Fly   154 IVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQ 218
                  .:..:.|:.|..:.|.::.|   |.||.:         ||:|..|.|.| .||
Zfish   196 ------RSGPQAKVRRGPAGAYQDPL---RNGSGI---------PTDRNRSPSAS-RDP------ 235

  Fly   219 QMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPS 283
            ...::|::....:|          |...:...|||...|..|
Zfish   236 NAAYNQREGEGGLQ----------YAPAEGGMPRSPSDYGRD----------------------- 267

  Fly   284 QVQPQHTPQSH------SQQQQSQ---HQQ-QHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQ 338
               |.|:|:|.      ...|.|:   |.| |||..|......|:..:::.|.:..|....|| .
Zfish   268 ---PGHSPRSSRMYNEVGDYQDSRGRWHSQGQHLDGQLDDYELQRRREEEYQARYRSDPNLAR-Y 328

  Fly   339 QHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQ-HG----QS-VPQMGGYQKPPP 397
            ..:.|.:::|::  .|||:.:  .:|...||.....:.::... ||    || :|.:||     |
Zfish   329 PIKPQPYEEQMR--IHAQVSR--ARHERRHSDVSLAYTELDEPLHGPGGRQSRLPLLGG-----P 384

  Fly   398 LTRNLTI---SGGHAMDSSAYSQQQQQ----QQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQ 455
            ..|:.::   |.||.|.:.:.....:.    ..||.||........|          ||.
Zfish   385 SQRSYSVDRSSPGHRMSNHSPPTPHRSPVLGDSRRGLAEPTRKPIPQ----------QHH----- 434

  Fly   456 GAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYAS 520
                                 |||                               |.|.:|
Zfish   435 ---------------------LDP-------------------------------SSAMRR---- 443

  Fly   521 ADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGA 585
             ::||:.:..|::                    :||:....|                      :
Zfish   444 -NKRDKMDNMLRN--------------------DSLSSDQSE----------------------S 465

  Fly   586 YRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAAT-----AA 645
            .|..||                   .|....::      |..|..||.:|.....|.|     ..
Zfish   466 VRPPPP-------------------RPHRSKRL------GKLRTMGSFSSSEEELATTPEYTSCE 505

  Fly   646 DAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRF 710
            |.:.::...|::|.:....|        .:.|.||:.:  ||.:.|..|::          .|||
Zfish   506 DVELESESISEKGNIQRGKR--------KTNEQAYFLD--TSYAPSERQNT----------VVRF 550

  Fly   711 --DAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQD 773
              .:|:|:                                          |:|.          :
Zfish   551 WEGSHEED------------------------------------------AEWC----------E 563

  Fly   774 SATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYY-------DGEDILG 831
            ...||||:||.|:.|.:|:.:..|  |:||.||.|.|..||||.::|.|..       |...:||
Zfish   564 PQVKDSGVDTCSSTTLNEEHSHSD--KHPVTWQPSKDGERLIGRVVLNKRMKDGTVPRDTGALLG 626

  Fly   832 LKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHN 896
            |||.||:...:|..               | |.:.||||||:||..|.:||||::||||||.|..
Zfish   627 LKVVGGKMTESGRL---------------C-AFITKVKRGSLADTVGHLRPGDQVLEWNGRVLQG 675

  Fly   897 KSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPH 961
            .:..|||:||.||:.:.||||:||||||          :|..|..::.|...|     ||::|
Zfish   676 ATFKEVYNIILESKPEPQVELVVSRPIG----------DVPRIPESTHGQLES-----SSSSF-- 723

  Fly   962 SGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDI--HTSVSGPGSVSGSG 1024
                                          |..:..||:.:|||.||.:  .||....|.:|...
Zfish   724 ------------------------------ESQKMGPSISVTSPMSPGMLRDTSQYLSGQLSSPC 758

  Fly  1025 LRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGT 1089
            |.:|
Zfish   759 LSRR------------------------------------------------------------- 762

  Fly  1090 TTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQL 1154
                                                                ||..:|   |:|:
Zfish   763 ----------------------------------------------------TTAFVP---RVQV 772

  Fly  1155 KLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTF 1219
            ||.||:...|||||::.|..|..|:.|..||||.|::.|||||.|||||||||..:.||:|.|||
Zfish   773 KLWYDKVGHQLIVTILGAKDLPPREDGRPRNPYVKIYFLPDRSDKSKRRTKTVKKSLEPKWNQTF 837

  Fly  1220 VYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLR 1282
            :||.:.|.:...|:|||||||.  ||...::|:||::|:|...:|||:..||:||.|
Zfish   838 MYSPVHRREFRERMLEVTLWDQARVREEESEFLGEILIELETALLDDQPHWYKLQTH-------- 894

  Fly  1283 DEGSDVDGLIL-TPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLN 1346
                ||..:.| .|:     |....||          :.|.:|...:.:.|     |....
Zfish   895 ----DVSSMPLPNPS-----PYMQRRL----------LHGESPTRRLQNKG-----PYFFN---- 931

  Fly  1347 ERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQ 1411
                      .|.:|::.....||....|||        ....||..|.:...|.:......:|
Zfish   932 ----------SGSQRISDSEFSDYDCEDGIG--------VISDYRHNGRDFQSSTLSVPEQVMS- 977

  Fly  1412 RSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQ 1476
             |:..:.||...:               ||.||   |:.||..|.:|:.|       ...||.|
Zfish   978 -SNHCSRSDMIRT---------------RSRSP---SVPPPQSRSLDHGV-------RGGPSHY- 1015

  Fly  1477 GPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGR 1541
            ||           |.:..:.|.       ||....|...|:|.......|...||
Zfish  1016 GP-----------QHRLSEDRY-------SPDSHYLTLPPRTRHRQASIDSAVQD---------- 1052

  Fly  1542 FGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMES 1606
            ...|...:.......|||.|.   |.|   ||...:|:|.|||               .|..|
Zfish  1053 PSMHPLFREDAVKLLRSTRMA---RAY---SDGAYNSLDRRMR---------------RDRQM-- 1094

  Fly  1607 VVSVTSSAFSTQSERP-RTSRG---LSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRAN 1667
                  |.:|...|.| |...|   :|.|  |      .|..:.|.||:..|..|: ..||
Zfish  1095 ------STYSDSYESPERYYNGPNHVSTP--W------PNHVMNGTGGDYRTCPRI-EIEP---- 1140

  Fly  1668 TIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAAL-AAADSPPISAGIGIQ----PPHQVLVTDANS 1727
            :.:.:..|.:|...|......|.|....:..:: .:..|.|:|:..|.|    ||...:  |...
Zfish  1141 STDTEREDQIPEFPANHDHFEEDLRANPRTGSVQTSPTSTPMSSRRGRQLPQVPPKGSM--DRKD 1203

  Fly  1728 GQLVEQFYVEPGTMAEEMMEPLDPHL--HPHSVFYSPSPHL----PPQPFDIDIDTIYPPRRSNG 1786
            |:.:.:.| |.||.|........|.|  ||.:|.......|    ||.|..:.
Zfish  1204 GEGITEPY-EAGTGAGPQPPAPPPVLSQHPQTVAAVGGASLHQAPPPPPLQVP------------ 1255

  Fly  1787 LKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQ 1851
                 ||.||                                               :|....||
Zfish  1256 -----QAVAA-----------------------------------------------MGGAVQHQ 1268

  Fly  1852 DKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMC 1916
                  .|....|.|:.         |..|:|...            |||     .||...|.:.
Zfish  1269 ------AQPPPPPQVIQ---------AVAAVGGAS------------QHQ-----APPPPQPQIT 1301

  Fly  1917 GECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDAL 1981
             :.|..|           :|::|      |.|       |....||.||.|:
Zfish  1302 -QAVAAH-----------VGMMP------PVP-------GPPTAPATPPAQA------------- 1328

  Fly  1982 VAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYP 2046
                |...|...|||.|..|....:.            ..:|..              ||:...|
Zfish  1329 ----PPPPAHPNPTSSLASPPTHAQP------------PQMHAP--------------PSATPAP 1363

  Fly  2047 YPHSNPYSS----YSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSD 2107
            .|.:.|.:|    .:|..|.:.:..:.:.:.|:          .||.|.
Zfish  1364 TPTAPPPASALPPQAPPPAPAAQSSASSLVHQA----------SLSESQ---------------- 1402

  Fly  2108 VGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAH 2172
                .|.|||....|          |..::.:.|   |:|:  ||.        :.....::|..
Zfish  1403 ----ERPVAPPPVNG----------RKEVTWEDQ---QKKI--PAL--------MSESTVSENGD 1440

  Fly  2173 NFSPMEPGS-GMDGLNAAAAGM-VEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQLQ 2235
            ..:..:|.. |||.|:..::.. |...:.|.|.               |:.||.|.....:::::
Zfish  1441 AGTLKDPSKRGMDSLSMRSSDSDVSDVSAMSSA---------------SRLSSTSYMSVQSERVR 1490

  Fly  2236 QQQQLQQ-QSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSS 2299
            ..:::.: ::::.:|:|||..:       |:|.::|:     .|...||....||.:..:
Zfish  1491 ASRKISRGEALQSQGEEGTVVV-------EELVEAST-----ASVQRAGLEGEGGRSIEH----- 1538

  Fly  2300 FANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPP 2364
                    |:::::        ....:||.::||..|
Zfish  1539 --------PEEEEE--------EEEPERAQTATPGSN---------------------------- 1559

  Fly  2365 NTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTT 2429
                             .|.||:......:...|
Zfish  1560 -----------------ITKSSSVGGDMCSLGRN------------------------------- 1576

  Fly  2430 NANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLS 2494
                                        |||    |.||......|...:|.
Zfish  1577 ----------------------------DDD----DDDKKRRSSFGAKMAAM------------- 1596

  Fly  2495 DTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGKKGKN-SFTVHRSEEVLPG 2558
                                 .|:||||.|||||.....      |||.|. ...:.||.|.
Zfish  1597 ---------------------VGLGKKSQSTSQLDPEEE------GKKKKPVRLAIQRSVET--- 1631

  Fly  2559 DITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSE-VDAIEQFFGDGAGGERFSPSLR- 2621
                      ||.:.:...              ::|..|.| .|..|:    ...|....|.::
Zfish  1632 ----------GLAIEMKSR--------------MTRQPSRETTDDSEK----PKPGNLIFPGVKI 1668

  Fly  2622 -NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAP 2685
             .|....||:|||||.||.|||.|..|.:||||:.:.|:|..|:|||||||||..|..:|..|||
Zfish  1669 SKDSQFTEFLDGLGPAQLAGRQTLATPPMGDIQIGMVHRKERLDVEVIRARGLVGKPGNKQTPAP 1733

  Fly  2686 YVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQ 2750
            ||||||:...:||:|.||.:||:||||||||||.|::|..|.:|||.|||||||::.|.|||.||
Zfish  1734 YVKVYLLDNGKCVNKKKTRTARKTLDPLYQQQLQFEESPEGKVLQIIVWGDYGRMDHKSFMGAAQ 1798

  Fly  2751 IMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSR 2786
            |:||||.|:|:||||||||..||||. ||...|.|:
Zfish  1799 ILLDDLELTNMVIGWYKLFPPTSLVD-PTLAPLSSK 1833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	66/161 (41%)
		PDZ_signaling	817..919	CDD:238492	44/108 (41%)
		C2A_RIM1alpha	1148..1272	CDD:175997	63/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	90/141 (64%)
rims2b	XP_021323970.1	PHD_SF	25..191	CDD:328929	67/177 (38%)
		FYVE_like_SF	<144..191	CDD:333710	29/58 (50%)
		PDZ_signaling	616..698	CDD:238492	42/97 (43%)
		C2A_RIM1alpha	769..892	CDD:175997	63/122 (52%)
		C2B_RIM1alpha	1681..1826	CDD:175994	92/145 (63%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4404
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm24270
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.020