Protein Alignment Rim and rims2a

DIOPT Version :10

• Sequence 1: NP_001247163.1
• Gene: Rim / 42150
• FlyBaseID: FBgn0053547
• Length: 2798
• Species: Drosophila melanogaster
• Sequence 2: XP_073782743.1
• Gene: rims2a / 393672
• ZFINID: ZDB-GENE-040426-1656
• Length: 1489
• Species: Danio rerio
• Alignment Length: 2863
• Identity: 604/2863 - (21%)
• Similarity: 869/2863 - (30%)
• Gaps: 1462/2863 - (51%)

  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVELD 65
            :.|||||||||..||..|..|:.|||:||||:..::::       |..|.....:|.:|.|.|..
Zfish    13 LPEMPDLSHLTEEERKIILGVMDRQKKEEEKEQSMLKK-------LHQQFEMYKDQVQKMGEEAQ 70

  Fly    66 A---------TCHICLKTKFADGVGHICHYCNIRCCARCGGKVTLRSNKVIWVCILCRKKQELLS 121
            :         ||.||.|||||||.||:|.||..:.||||||:|:||||||:|||.||||:||:|:
Zfish    71 SGPEQKSDAPTCGICHKTKFADGCGHLCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILT 135

  Fly   122 KTGQWINKTAAQQDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKLERT----RSAAEKENLP-M 181
            |:|.|.   .:...|.:    |.|:||..:.....|.   :|:.||:..    :|:.::...| :
Zfish   136 KSGAWF---FSGPGGAL----PAGASDPRRRHEEAPQ---EKKAKLQEAPLLYQSSGDRSRAPGL 190

  Fly   182 QRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQ 246
            .|..|:......:...||:.|..:..:..||      ..:::|::::|......|.:.    ||
Zfish   191 PRQASLNNNSSLKPNDPTSNRKRSPSATRDP------NQKYNQREEKADRSQYAPGEG----GM- 244

  Fly   247 QQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQ- 310
                |||...|...| |.::|   |..|        |....:....::..::...|.|:...|:
Zfish   245 ----PRSPSDYGAGD-RQWRG---GCGR--------SYEDAEVARGAYRARRGGWHSQEEYPPEP 293

  Fly   311 ---QHRPSPQQHSQQQQQQQQHSQQFAA----RQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPH 368
               ...|...:|..|:|:|:::..::.:    .:...:.|.:::|::.  ||::.:  .:|...|
Zfish   294 GFLPDGPPLSEHELQRQRQEEYQNRYRSDPNLARYPVKPQPYEEQMRM--HAEVSR--FRHERRH 354

  Fly   369 SQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYA 433
            |.....:.:|:...|   |..|.:..|.                   |.|...:...:..|:..|
Zfish   355 SDVSLAYTEMEEPLG---PLRGPHYSPG-------------------SGQTHWRSNHSPPGTDSA 397

  Fly   434 SQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGG 498
            .:||            ||                         |||
Zfish   398 HRQQ------------QL-------------------------LDP------------------- 406

  Fly   499 GGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTRTARLDVQQRNSLNRSNHER 563
                                .||.::.:       ||::|                |:.|::
Zfish   407 --------------------VSAVRKSK-------REKME----------------SMLRND--- 425

  Fly   564 QFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDR 628
                                                |.||..:.|...|..||
Zfish   426 ------------------------------------SLSSDQSESVRPPPPKP------------ 442

  Fly   629 GSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAA 693
                                    ..::|||.:...       |:||:|    :|.||:...::.
Zfish   443 ------------------------HKTKRGGKMRQV-------SLSSSE----EELATTPEYTSC 472

  Fly   694 QD--------SRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKS 750
            :|        |.:...:|.|:.....:|                              .||.|:.
Zfish   473 EDVEIESESVSEKGDSQRGKRQTFEQSH------------------------------TLSEGQK 507

  Fly   751 LDAVGVGGADW---SRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNT 812
             ..|..||..|   :.| .|.|      .||||:||.|:.|.:|:.:..:  |:||.||.|.|..
Zfish   508 -KMVRFGGHSWEEDAEW-CEPQ------VKDSGVDTCSSTTLNEEHSHSE--KHPVTWQPSKDGD 562

  Fly   813 RLIGHMILRKYY-------DGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKR 870
            ||||.::|.|..       |...:|||||.||:...:|..               | |.:.||::
Zfish   563 RLIGRILLNKRMKDGSVPRDSGALLGLKVVGGKMTESGRL---------------C-AFITKVRK 611

  Fly   871 GSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSAN 935
            ||:||..|.:||||::||||||.|...:..|||:||.||:.:.||||:||||||
Zfish   612 GSLADTVGHLRPGDQVLEWNGRQLQGATFKEVYNIILESKPEPQVELVVSRPIG----------- 665

  Fly   936 VSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSV 1000
                         .:|....|.   |:.|.||                 :.:.|:.::.|  ||:
Zfish   666 -------------DIPRIPEST---HAQLESS-----------------SSSFESQKMER--PSI 695

  Fly  1001 LITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAP 1065
            .:|||.||.:              ||
Zfish   696 SVTSPMSPGV--------------LR--------------------------------------- 707

  Fly  1066 ASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVG 1130
                           .||..|.|..|
Zfish   708 ---------------DAPQYLSGQLT--------------------------------------- 718

  Fly  1131 GGIGMGSGSGTTTQPI-PIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLP 1194
                    |.:.::.| |...|:|:||.||:...|||||::.|..|..|:.|..||||.|::.||
Zfish   719 --------SQSLSRRIEPFNPRVQVKLWYDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLP 775

  Fly  1195 DRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDL 1257
            |||.|||||||||..:.||:|.|||:||.:.|.:...|:||:||||.  ||...::|:||::|:|
Zfish   776 DRSDKSKRRTKTVKKSLEPKWNQTFMYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIEL 840

  Fly  1258 AHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGM 1322
            ...::|||..||:||.|            ||..:.|..    |.||...|....|:
Zfish   841 ETALVDDEPHWYKLQTH------------DVSSVPLPK----SSPSLQRRALHGDS--------- 880

  Fly  1323 TPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASAT 1387
                            |...|..::|.|..:.|             ||....|:|        ..
Zfish   881 ----------------PTRRLQRSQRISDSEFS-------------DYDCEDGVG--------VV 908

  Fly  1388 GYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPP 1452
            ..||.|                                                ...:..:||.|
Zfish   909 SDYRNG------------------------------------------------RDLQSSTLSVP 925

  Fly  1453 DDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQ 1517
            :.      ||.                  |:..:.::...|.:|||    |:..|.:.....:|:
Zfish   926 EQ------VLS------------------SNHCSRSADINRARSRS----PSMPPSQSHFLTLPR 962

  Fly  1518 TSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDAR 1582
            |..|                           |||                     ||||  .|.|
Zfish   963 TRHS---------------------------QPH---------------------DSDL--QDLR 977

  Fly  1583 MRPRHSLSPDK-DFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLG 1646
               .:..:||: ::......:|..:.:           |||..||..|..|
Zfish   978 ---NYGGAPDRHEYHHRSRSADQRAAM-----------ERPMYSRSRSTER-------------- 1014

  Fly  1647 GAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAG 1711
                                                                             
Zfish  1015 ----------------------------------------------------------------- 1014

  Fly  1712 IGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDID 1776
                ||                                            ..||:
Zfish  1015 ----PP--------------------------------------------DGPHM---------- 1021

  Fly  1777 TIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPS 1841
                  ||:              :|.|||..     :.|       ||||
Zfish  1022 ------RSS--------------MPSLPSGH-----SAP-------SSPA--------------- 1039

  Fly  1842 SLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYG 1906
                                                             |:.|||.
Zfish  1040 -------------------------------------------------LSRAHPR--------- 1046

  Fly  1907 EPPSSDPAMCGECVDQHFLGG--LTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSV 1969
                               ||  .|.|             |.||...||.|   ..|..||..::
Zfish  1047 -------------------GGSVQTSP-------------TGTPINSRRGR---QLPQLPPKGTL 1076

  Fly  1970 LRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRY 2034
            .|...:...:|...|:.:.|...|     .|.|:.:   :.:|.
Zfish  1077 ERKDGEEEVEACPGALDVEERTRQ-----MKLKMNK---YKQGT--------------------- 1112

  Fly  2035 EDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKI 2099
                                            ||::.:.|.|
Zfish  1113 --------------------------------GSDSRLEQDY----------------------- 1122

  Fly  2100 VTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPH 2164
                                    |::.| .||
Zfish  1123 ------------------------HKRSG-RDP-------------------------------- 1130

  Fly  2165 PPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQS 2229
                |...|.|.....|.:..::|                    .|..:|....|..|.:||
Zfish  1131 ----QRGENLSAKSSDSDVSDVSA--------------------VSRTSSASRFSSMSYISV--- 1168

  Fly  2230 HNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANN 2294
                 |.::....:.:||.|    ||..|:|      |||:|               :||
Zfish  1169 -----QSERPRGSRKIRQMG----TAAGGNM------TKSTS---------------IGG----- 1198

  Fly  2295 ASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQ 2359
                                                                             
Zfish  1199 ----------------------------------------------------------------- 1198

  Fly  2360 LQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATT 2424
                 :.|
Zfish  1199 -----DMC--------------------------------------------------------- 1201

  Fly  2425 TTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKV 2489
                                                                        :.:|.
Zfish  1202 ------------------------------------------------------------SLEKT 1206

  Fly  2490 DGSLSDTA------NDRKKGGGVDQERSPKGGS-----GMGKKSNSTSQLSAT---GRKRRMGFG 2540
            |||.||||      :|:|:       ||..|..     |:.:||.|.|||..|   |:|.|.
Zfish  1207 DGSQSDTAVSLVGTDDKKR-------RSSIGAKMAAVVGLSRKSRSASQLGQTEAGGKKLRS--- 1261

  Fly  2541 KKGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQ 2605
                   |:.||.|.             ||.|.:...              ::|.:|.|..
Zfish  1262 -------TIQRSTET-------------GLAVEMRSR--------------MTRQASREST---- 1288

  Fly  2606 FFGDG------AGGERFSPSLR--NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGC 2662
               ||      :.|....|.:|  :|...::|:|||||.||||||.|..|.:||||:.:..:||.
Zfish  1289 ---DGSMNSYSSEGNLIFPGVRLSSDSQFSDFLDGLGPAQLVGRQTLATPPMGDIQIGMVEKKGA 1350

  Fly  2663 LEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGC 2727
            |||||||||||..|..||.||||||||||:....|:.|.||..||:||||||||||.|::|..|.
Zfish  1351 LEVEVIRARGLVGKPGSKALPAPYVKVYLLENGACIAKKKTKVARKTLDPLYQQQLSFEESPGGK 1415

  Fly  2728 ILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIAS 2792
            :|||.|||||||::.|.|||.|||:||||:|||:||||:|||..:|||. ||...| :||:|..|
Zfish  1416 VLQIIVWGDYGRMDHKSFMGAAQILLDDLDLSNMVIGWFKLFPPSSLVD-PTLAPL-TRRASQTS 1478

  Fly  2793 LDS 2795
            |||
Zfish  1479 LDS 1481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:473978	62/126 (49%)
		PDZ_RIM-like	813..920	CDD:467198	46/113 (41%)
		C2A_RIM1alpha	1148..1272	CDD:175997	62/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	92/141 (65%)
rims2a	XP_073782743.1	None