DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and Fife

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	NP_001261340.1	Gene:	Fife / 38337	FlyBaseID:	FBgn0264606	Length:	1314	Species:	Drosophila melanogaster

Alignment Length:	1537	Identity:	299/1537 - (19%)
Similarity:	441/1537 - (28%)	Gaps:	631/1537 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 QQQQHHQQMQHQHGQSVPQMGGYQK----------------------PPPLTRNLTISGGHAMDS 412
            :|....||.....|....|.|...|                      |..:..:...||.:.  |
  Fly    18 EQTSERQQHAADSGGGASQTGALNKMKATISSSLLTVTDKVNKMSPRPSLVPTDADTSGSYG--S 80

  Fly   413 SAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSL 477
            .:|..||||||                                         ||..
  Fly    81 PSYQSQQQQQQ-----------------------------------------DYGS--------- 95

  Fly   478 DPWRQQRSLNERDLLSSGGG----GGGGVGGA----------------------DFRHLSHAT-- 514
                   |||..:..|||||    ||||.|.|                      |:    |.|
  Fly    96 -------SLNNNNNNSSGGGTATTGGGGGGAAAKQEPGRRAGACRVCLKSFKPDDY----HKTCF 149

  Fly   515 ---QRL------YASADQRD---RYELQLQHRERLEQ--YPLTRT-ARLDVQQRNSLNRSNHERQ 564
               ||:      |:..|:.:   .:...:..|:...:  .|...| :.|||....:|.|.:.:.:
  Fly   150 ECQQRVCEDCASYSKLDEHEDATMWRCSVCRRKMASRVCIPQDSTDSMLDVPVLEALQRRHSDAK 214

  Fly   565 FSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRG 629
            .......:.|    ..|||.|..|:|.|        ...|..|.:...:.:.|:         :|
  Fly   215 LGSSTQTLAP----SNGAALAPPRSPEL--------RRHSDVSPASLKELERQL---------KG 258

  Fly   630 SGSMASMASAAAATAADAQGQ-------AARNSQRG---------------GLLGATRGGGGSSS 672
            ..|||...|.:........||       :...|:||               |.:|.:.||||.:.
  Fly   259 GRSMAPSRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGPVGGSMGGGGPAL 323

  Fly   673 VSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAV 737
            ....:.|....|......|                    |:|..|..|......|.|.:..|.
  Fly   324 GLGADGAGLGIPTMPRRKS--------------------AYDVFAPGLTQGGATPATQLQRSP-- 366

  Fly   738 DVGAATILSSGKSLDAVGVGGADWSRWEAER--------QGSQDSATKDSGIDTSSTFTSSED-- 792
                    ..|..:..:.:.|   ||..:.|        |......:.|.|   |...|..:|
  Fly   367 --------GEGGIMPPIQLPG---SRRPSFRVPHPSEDIQNDDSPGSPDKG---SPVLTVDDDRR 417

  Fly   793 --------------SNRGDGPKNPVN---------------------WQTSADN--TRLIGH--- 817
                          .|||..|..|.:                     .|||.|.  .|::.|
  Fly   418 MRRRGSQLPDIAMLQNRGALPAVPPSSIPPPMASFTGPNLEDLEAPRRQTSMDGEAIRIVIHDVD 482

  Fly   818 ----------MILRKYYDGEDI------LGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVE 866
                      :|||:  |..|.      .|::|.||:                .||.|...|.:.
  Fly   483 SGPICASKRRIILRR--DPTDKAHRTRGFGMRVVGGK----------------TGADGRLFAYIV 529

  Fly   867 KVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSR---------- 921
            ....|..|:..| ::.||:||||||..|.::|.:||..|:|  |....|||:|..
  Fly   530 WTVPGGAAEKNG-LQQGDKILEWNGMSLIDRSFEEVCSIMD--RTGDVVELLVEHATDFRMCDLF 591

  Fly   922 ----PIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQ 982
                |.|:.||..|                   |.|
  Fly   592 DENLPPGNAGGQSG-------------------PRR----------------------------- 608

  Fly   983 RKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHS 1047
                                            ||.|.|
  Fly   609 --------------------------------SGDGPV--------------------------- 614

  Fly  1048 SSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPH 1112
              |.|..:...|::..:|||                                     |.:..||.
  Fly   615 --GLGLIAEPETTTDKSPAS-------------------------------------PTRRKLPK 640

  Fly  1113 -PHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLS 1176
             |.|                          ..:...:.||:|:::.|.....:|:|:|:....|:
  Fly   641 TPEQ--------------------------IAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLA 679

  Fly  1177 LRQS--GAGRNP--YAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVT 1237
            .|..  |.|..|  ||||.:||.....|.::|:....|..|.|..|..:..::...|..|.:::.
  Fly   680 PRDEAYGHGNLPEAYAKVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQ 744

  Fly  1238 LWDYVRYGANDFIGEVVIDLAHHILDDEAEWYQLQ----------------------------PH 1274
            |||.|.:..:.|:||..|:|....|||:|.|.:|:                            |.
  Fly   745 LWDLVPHTESIFLGECSIELQQAFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSIAAGAGAPS 809

  Fly  1275 QDTSYLLR-----------DEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTS------DCDIDGM 1322
            .|.:.|||           |..|..||..|...||.....:....|.|:|..      ..|....
  Fly   810 GDVTRLLRRDYNMQRSNSDDVDSIGDGTSLLHPDHAWIAGSRRGSSQSETMEVEVYQLGKDFSRS 874

  Fly  1323 TPGASISSM----------GSSASPPPLLELDLNERRS---RRDMSP--QGRKRVAGMVARDYRT 1372
            .||:..||.          .:.|:||  ....:..|||   |||...  :..|.|.|.:.   ||
  Fly   875 LPGSRRSSFQDAEKNRLEEDAMATPP--TSYLVGRRRSSVARRDPDEILKSLKAVRGELG---RT 934

  Fly  1373 VSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAY 1437
            :| :|...|.:..:    ||  .:.||...||     |.|..|.......|...:
  Fly   935 MS-LGTEQHKRMGS----RR--ASRVGLPSGP-----SSRKSSVLDLSQQHQQQL---------- 977

  Fly  1438 GYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSR---SA 1499
                  .:...|.....:|:... ||:            |.|...::..|..:.:|::.|   |.
  Fly   978 ------QQLQQLQLQQQQYLQQQ-LPM------------GVGNADTSPPSEDEDKRYRPRWKGSV 1023

  Fly  1500 TATPTGSPKK--RQLPQVPQTSRSAMLRDRLGQ-----DFDERLASGGRFGRHRTRQPHHQATY- 1556
            :..|..|||:  .:|.|....|..|....|.||     ...:|.:|..:.|..:...|....|:
  Fly  1024 SQLPPQSPKQALSRLKQAASASNVAQDTQRQGQLLTTNPLQQRKSSMFQLGESQASPPTTTTTHL 1088

  Fly  1557 -RSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSE 1620
             |...|     :...::::..|....|.                |.....|||.:  |..|..::
  Fly  1089 QRKGSM-----YVAKVTETPPHGTPTRK----------------GSVYQRSVVGL--SVDSPGAD 1130

  Fly  1621 RPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSE 1662
            .|:..:.:.     :.|.|...:.....|||...||:|..|:
  Fly  1131 SPQRKQSVV-----KTLSGSYVNICPLTGGESSYGLKLGPSQ 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600
		PDZ_signaling	817..919	CDD:238492	35/120 (29%)
		C2A_RIM1alpha	1148..1272	CDD:175997	40/127 (31%)
		C2B_RIM1alpha	2633..2775	CDD:175994
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290	8/60 (13%)
		PDZ_signaling	491..580	CDD:238492	34/109 (31%)
		DegQ	<526..577	CDD:223343	20/53 (38%)
		C2A_RIM1alpha	651..779	CDD:175997	40/127 (31%)
		C2	1163..1304	CDD:301316	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010