DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and RIMS1

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	NP_055804.2	Gene:	RIMS1 / 22999	HGNCID:	17282	Length:	1692	Species:	Homo sapiens

Alignment Length:	2908	Identity:	619/2908 - (21%)
Similarity:	893/2908 - (30%)	Gaps:	1356/2908 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMR--------------------RKQDEVVT 45
            |.|:|||||||..||..|..|:.|||:||||:..:::                    :.......
Human    19 MQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAENQPHQPSPR 83

  Fly    46 LEMQIRQRSEQQKKAGVEL---------DA-TCHICLKTKFADGVGHICHYCNIRCCARCGGKVT 100
            |..|.....||.:|.|.|.         || ||.||.|||||||.||:|.||..:.||||||:|:
Human    84 LHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFADGCGHLCSYCRTKFCARCGGRVS 148

  Fly   101 LRSNK----VIWVCILCRKKQELLSKTGQWINKTAAQ---QDGFIRRIEPDGSSDISQHPIVDPH 158
            ||||.    |:|||.||||:||:|:|:|.|...:..|   |||.:........|::.:
Human   149 LRSNNEDKVVMWVCNLCRKQQEILTKSGAWFFGSGPQQTSQDGTLSDTATGAGSEVPR------- 206

  Fly   159 DTTDKRPKL-ERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQH 222
               :|:.:| ||:||     ..|:..|.:.     ||...|.:.....|...     .|.||...
Human   207 ---EKKARLQERSRS-----QTPLSTAAAS-----SQDAAPPSAPPDRSKGA-----EPSQQALG 253

  Fly   223 HQQQQ---RARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQ 284
            .:|:|   |:|.:|  |::.::..|:.:|   ...||...:..|
Human   254 PEQKQASSRSRSEP--PRERKKTPGLSEQ---NGKGALKSERKR--------------------- 292

  Fly   285 VQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQV 349
                 .|::.:|..:...::     ::.:...:....::.:.|.:......|.:.....:.:|:.
Human   293 -----VPKTSAQPVEGAVEE-----RERKERRESRRLEKGRSQDYPDTPEKRDEGKAADEEKQRK 347

  Fly   350 QQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSA 414
            ::.|..:....|....:|                         .||||
Human   348 EEDYQTRYRSDPNLARYP-------------------------VKPPP----------------- 370

  Fly   415 YSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDP 479
                 ::||.|..|
Human   371 -----EEQQMRMHA--------------------------------------------------- 379

  Fly   480 WRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHRERLEQYPLTR 544
             |..|:.:||                  ||...|..|..|
Human   380 -RVSRARHER------------------RHSDVALPRTEA------------------------- 400

  Fly   545 TARLDVQQRNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSS 609
                                    ||.:..|.||        :|||..|.|.
Human   401 ------------------------GAALPEGKAG--------KRAPAAARAS------------- 420

  Fly   610 YYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVS 674
              |...|:                |..|...|.|.|....|...:|.     .|.|.|...:...
Human   421 --PPDSPR----------------AYSAERTAETRAPGAKQLTNHSP-----PAPRHGPVPAEAP 462

  Fly   675 STEAAYWDEPATSSS---SSAAQDSRRFTERRIKKTVRFD--AHDEEASILASSSLPPVTAILPS 734
            ..:|   .||....|   .|:|...|:....:::..:|.|  :.|:..|:..|   ||    .|.
Human   463 ELKA---QEPLRKQSRLDPSSAVLMRKAKREKVETMLRNDSLSSDQSESVRPS---PP----KPH 517

  Fly   735 TAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSED------- 792
            .:                         .|...:||.|. |::::.|:.|.. :||.||
Human   518 RS-------------------------KRGGKKRQMSV-SSSEEEGVSTPE-YTSCEDVELESES 555

  Fly   793 -SNRGD----------------GP--KNPVNWQTSADNTRLIGHMILRKY----YDGEDILGLKV 834
             |.:||                .|  .:||.||.|.:..||||.:||.|.    .|...:|||||
Human   556 VSEKGDLDYYWLDPATWHSRETSPISSHPVTWQPSKEGDRLIGRVILNKRTTMPKDSGALLGLKV 620

  Fly   835 NGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSA 899
            .||:....                |..||.:.|||:||:||:.|.:|.|||:|||||:.|...:.
Human   621 VGGKMTDL----------------GRLGAFITKVKKGSLADVVGHLRAGDEVLEWNGKPLPGATN 669

  Fly   900 DEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFPHSGL 964
            :|||:||.||:.:.|||:|||||||                        .:|....|::.|....
Human   670 EEVYNIILESKSEPQVEIIVSRPIG------------------------DIPRIPESSHPPLESS 710

  Fly   965 ASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQRG 1029
            :||.....:                      ::||:.:.||.||
Human   711 SSSFESQKM----------------------ERPSISVISPTSP--------------------- 732

  Fly  1030 GVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGLHGTTTAGH 1094
                                                           .|...||
Human   733 -----------------------------------------------GALKDAP----------- 739

  Fly  1095 HHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYD 1159
                                                             |.:|  |:|.:||.||
Human   740 -------------------------------------------------QVLP--GQLSVKLWYD 753

  Fly  1160 QNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGL 1224
            :...||||.::.||.|..|..|..||||.|::.|||||.|||||||||....||:|.||||||.:
Human   754 KVGHQLIVNVLQATDLPARVDGRPRNPYVKMYFLPDRSDKSKRRTKTVKKILEPKWNQTFVYSHV 818

  Fly  1225 RRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSD 1287
            .|.|...|:||:|:||.  |:...::|:||::|:|...:||||..||:||.|.::|..|.....
Human   819 HRRDFRERMLEITVWDQPRVQEEESEFLGEILIELETALLDDEPHWYKLQTHDESSLPLPQPSP- 882

  Fly  1288 VDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRR 1352
                 ..|..|:...|:..:|..|...||.||.
Human   883 -----FMPRRHIHGESSSKKLQRSQRISDSDIS-------------------------------- 910

  Fly  1353 DMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAA 1417
                            ||....|||                                      ..
Human   911 ----------------DYEVDDGIG--------------------------------------VV 921

  Fly  1418 PSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVS 1482
            |..||.||          |...:||     :|:.|:
Human   922 PPVGYRSS----------ARESKST-----TLTVPE----------------------------- 942

  Fly  1483 SAAASASQQQRFQSRSATATP-----TGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRF 1542
                   ||:....||.:.:|     .|.|:.| ||.||           |.:..||...:
Human   943 -------QQRTTHHRSRSVSPHRGNDQGKPRSR-LPNVP-----------LQRSLDEIHPT---- 984

  Fly  1543 GRHRTRQP--HHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDME 1605
              .|:|.|  ||.|: ||                   .:|.|.|     ..|..::.| .||::.
Human   985 --RRSRSPTRHHDAS-RS-------------------PVDHRTR-----DVDSQYLSE-QDSELL 1021

  Fly  1606 SVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIE 1670
            .:              ||..||.|
Human  1022 ML--------------PRAKRGRS----------------------------------------- 1031

  Fly  1671 VDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVLVTDANSGQLVEQFY 1735

Human  1032 ----------------------------------------------------------------- 1031

  Fly  1736 VEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPL 1800
                  ||.:      |...|.|.:..:  |||:                              :
Human  1032 ------AECL------HTTRHLVRHYKT--LPPK------------------------------M 1052

  Fly  1801 PLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDHQDKSCSH-CQNGSQP 1864
            |||.|...:        |.:.|..||        ||.|...:       .||.|..| |.|.:
Human  1053 PLLQSSSHW--------NIYSSILPA--------HTKTKSVT-------RQDISLHHECFNST-- 1092

  Fly  1865 VVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLT 1929
                   .|..|          |...:::..|                           ||....
Human  1093 -------VLRFT----------DEILVSELQP---------------------------FLDRAR 1113

  Fly  1930 GPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQP 1994
            ....|. :.|...:|:|     .|.||:.:
Human  1114 SASTNC-LRPDTSLHSP-----ERERGRWS----------------------------------- 1137

  Fly  1995 TSILKKPKLERRRLFHEGQSRSLDYDDLHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPT 2059
                  |.|:|||                                |.|......|::|.:.
Human  1138 ------PSLDRRR--------------------------------PPSPRIQIQHASPEND---- 1160

  Fly  2060 AAMSRRYGSETNIRQSYMGANVDANHPL-------SHSHFLVTDDKIVTITYDSDVGWTRRGVAP 2117
             ..||:....:..:|:..|...||...|       .|:....||..::
Human  1161 -RHSRKSERSSIQKQTRKGTASDAERVLPTCLSRRGHAAPRATDQPVI----------------- 1207

  Fly  2118 SLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAP------YLKRRRNLPHPPSAQNAHNFS- 2175
               ||.|..|..:.  .|.|:....:....:.|.:||      .:.|:|:....|.|..  :||
Human  1208 ---RGKHPARSRSS--EHSSIRTLCSMHHLVPGGSAPPSPLLTRMHRQRSPTQSPPADT--SFSS 1265

  Fly  2176 ------PMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQQL 2234
                  |..|         ..:|.:||.:.:..   ..|.......|...|.:....||..:::.
Human  1266 RRGRQLPQVP---------VRSGSIEQASLVVE---ERTRQMKMKVHRFKQTTGSGSSQELDREQ 1318

  Fly  2235 QQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSS 2299
            ..:..:.:...|               :.:.::..||.|..:..:|     :...::|:..||:|
Human  1319 YSKYNIHKDQYR---------------SCDNVSAKSSDSDVSDVSA-----ISRTSSASRLSSTS 1363

  Fly  2300 FANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPP 2364
            |.:.|...|:                .|..|.||:.....:.
Human  1364 FMSEQSERPR----------------GRISSFTPKMQGRRMG----------------------- 1389

  Fly  2365 NTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTT 2429
                                          |:..:...:|:.:....|..:|
Human  1390 ------------------------------TSGRSIMKSTSVSGEMYTLEHN------------- 1411

  Fly  2430 NANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLS 2494
                                                                        |||.|
Human  1412 ------------------------------------------------------------DGSQS 1416

  Fly  2495 DTANDRKKGGGVDQER--SPKGGSGMGKKSNSTSQLSAT--GRKRRMGFGKKGKNSFTVHRSEEV 2555
            |||......||..:..  |.|..:.:.::|.||||||.|  |.|         |...|:.||.|.
Human  1417 DTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHK---------KLKSTIQRSTET 1472

  Fly  2556 -LPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPS 2619
             :..::.:.:|.                .|..:..|.::..||.              |....|.
Human  1473 GMAAEMRKMVRQ----------------PSRESTDGSINSYSSE--------------GNLIFPG 1507

  Fly  2620 LR--NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKML 2682
            :|  .|...::|:|||||.||||||.|..|::||||:.:..:||.|||||||||.|.||..||..
Human  1508 VRLGADSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQLEVEVIRARSLTQKPGSKST 1572

  Fly  2683 PAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMG 2747
            |||||||||:....|:.|.||..||:||||||||.|||.:|..|.:||:.|||||||::.|.|||
Human  1573 PAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKVLQVIVWGDYGRMDHKCFMG 1637

  Fly  2748 VAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDS 2795
            ||||:|::|:||::||||||||..:|||. ||...| :||:|.:||:|
Human  1638 VAQILLEELDLSSMVIGWYKLFPPSSLVD-PTLTPL-TRRASQSSLES 1683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	64/151 (42%)
		PDZ_signaling	817..919	CDD:238492	42/105 (40%)
		C2A_RIM1alpha	1148..1272	CDD:175997	63/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	89/141 (63%)
RIMS1	NP_055804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/6 (67%)
		FYVE_like_SF	<131..186	CDD:333710	28/54 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..555		104/679 (15%)
		DUF601	191..>284	CDD:282493	25/122 (20%)
		TOP2c	<257..536	CDD:330395	77/560 (14%)
		PDZ_signaling	604..689	CDD:238492	40/100 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..732		8/55 (15%)
		C2A_RIM1alpha	742..868	CDD:175997	64/127 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	870..1013		54/328 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1222		31/209 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1235..1278		11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1332..1394		16/135 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1408..1428		9/92 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1445..1495		18/74 (24%)
		C2B_RIM1alpha	1523..1668	CDD:175994	91/145 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143512
Domainoid	1	1.000	144	1.000	Domainoid score	I4609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	617	1.000	Inparanoid score	I896
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm40596
orthoMCL	1	0.900	-	-		OOG6_103451
Panther	1	1.100	-	-	LDO	PTHR12157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2752
SonicParanoid	1	1.000	-	-		X2115
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.930