Protein Alignment Rim and cla-1

DIOPT Version :9

• Sequence 1: NP_001247163.1
• Gene: Rim / 42150
• FlyBaseID: FBgn0053547
• Length: 2798
• Species: Drosophila melanogaster
• Sequence 2: NP_001294148.2
• Gene: cla-1 / 177539
• WormBaseID: WBGene00018468
• Length: 8922
• Species: Caenorhabditis elegans
• Alignment Length: 3653
• Identity: 646/3653 - (17%)
• Similarity: 1070/3653 - (29%)
• Gaps: 1325/3653 - (36%)

  Fly     6 DLSHLTPHERMQIENV-LMRQKQEEEKQNEIMRRK-------------QDEVVTLEMQIR--QRS 54
            |.|.||..|:..|..: ||.:|.:||..:|..:.|             |..:...:..|:  |..
 Worm  5673 DESELTTEEKEHIRQMSLMAEKMDEEILDEQSKPKSTFGLKNFFGKATQSVMHATDSVIKNVQNQ 5737

  Fly    55 EQQKKAGVELDATCHICLKTKFA----------DGVGHIC------------------------- 84
            .:|..:|:..:...:|...|:.|          |.:.||.
 Worm  5738 SKQSLSGLTQEELDNIAQATESAQQESKQELTQDEIDHIARINAMAAEDFEQPAVNMNQGLSQAE 5802

  Fly    85 --HYCNIRCCAR--CGGKVTLRSNKVIWVCILCRKKQELLSKTGQWINKTAAQQD--------GF 137
              |...|...|.  ...|:.:....:|      :|..||..:....|.:.||..|        |.
 Worm  5803 KDHIARIEAMAADDSQSKIIVPPPSII------QKDIELSMEEMDHIARIAAMADEDFTHPVKGA 5861

  Fly   138 IRRI------EPDGSSD----ISQHPI-VDPHD---TTDKRPKLERTRSAAEKE-NLP--MQRAG 185
            :..|      ..||:.|    .:..|: ..|.:   :.::|..:.|..:.||:: |.|  .....
 Worm  5862 VAPIYDENYSRDDGAIDRFPASTATPVFAQPSEIELSEEEREHISRIAAMAEEDFNTPYVSTHPT 5926

  Fly   186 SMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPM-------NPQQAQQ-- 241
            ..:..:.:::|:....|:.|..|  :.:.:|...:   ||:||....|:       .|..:|:
 Worm  5927 QQIEIELTEEEKEHIARIEAMAS--EDLNAPSPFI---QQEQRVATMPVPINYHVEEPTLSQEEI 5986

  Fly   242 -------------GYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMR----------QHPHLA--H 281
                         ...:|....|:    ...::|...|.|:|.:.|          .:|.:.  |
 Worm  5987 DHIARITAMATEDNTDLQTLPTPQ----VKQNEPELSQEEIDHITRIAAMANEDFGMYPSIVSEH 6047

  Fly   282 PSQVQPQHTPQSHSQQQQSQH----------QQQHLMPQQHRPSPQQHSQQQ------------- 323
            |:.|:.:.|      |::..|          ....|.|...:||....:|::
 Worm  6048 PAPVESELT------QEELDHIAKITGMASMDISTLPPPTGKPSETSLTQEELDHIARIAEMASA 6106

  Fly   324 ---------------QQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQ 373
                           |::..|..:..|...|..|   ....|:|...::...|.. |.|....:|
 Worm  6107 EYDVPVKIFEPPELTQEELDHIAKITAMAAQDVQ---LPATQRSITHKVSLTPPP-PPPSKHFEQ 6167

  Fly   374 HHQQMQHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQR 438
            ...|.:..|...:.:|.......|.|              |...|.::::....:||
 Worm  6168 DLTQEELDHIARIAEMADMDYNTPFT--------------AEPVQDEEEEPITESGS-------- 6210

  Fly   439 SFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTS------------LD-------PWRQQR 484
            ..:|..:.|..|..|:.||    :|| :|....||.||            ||       |...|:
 Worm  6211 DATSGADIFDEQEDASSGA----SGS-FDNNNAQVLTSGFSPDRVTSPAALDTTEEPQGPIMAQK 6270

  Fly   485 SLN---ERDLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQ------HRER---- 536
            :::   ..|.::|...     ...|.|.:|...|.  :.:|....||.||.      |.|.
 Worm  6271 TVSPTPSADSMASRKS-----SEYDIRSISEIRQE--SESDIGKWYEEQLSFMRQSIHDEEEDVG 6328

  Fly   537 ------LEQYPLTRTA-RLDVQQRNSLNRSNHE----RQFSGGGAGVGPGGAGG-GGAAGAYRRA 589
                  :|::||.... :|...:...:...:||    ..|.|.|..:|.|.... |..|...::.
 Worm  6329 HEIRTDVEEFPLEYVEDQLHFLEGIDVESQHHEPTTSSAFFGTGRSIGEGEKRKYGDDAVEQQKL 6393

  Fly   590 PPLAAAGGGGSSSSSTTSSSYYPQSKPQIVIG-------PGSGYDR--GSGSMASMASAA--AAT 643
            ..........|||.......:..|.:..:...       |||...:  ..|.::::|:.|  .|.
 Worm  6394 ENYEEEEKTKSSSREAFDDGFETQREESLRAQQTPIDSLPGSRMLKRPNFGFLSNIANDAINKAK 6458

  Fly   644 AADAQGQAA----RNSQRGGLLGATRGGGGSSSVSSTE--------------------------- 677
            .|.:|.|||    .:|....::   .....|||.|||.
 Worm  6459 EAGSQIQAAVPIKPSSSSSNIV---NNNVFSSSKSSTSLGTSAPTKSIPSPQIGIPMDGLSEEER 6520

  Fly   678 --------AAYWDE------PATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSL--- 725
                    ||.:|:      |:||.||:........:|...:|.:         |::|::.:
 Worm  6521 RQIMSVMAAADFDDSVNNVKPSTSGSSNIPAGMEDLSEAEREKIM---------SVMANAEMEMG 6576

  Fly   726 ---PPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTF 787
               ||.::.:|:.:..|.:::|:|                    |.....|..:.|..:...:..
 Worm  6577 ARFPPPSSQIPTRSPSVMSSSIMS--------------------ELPPGLDDLSDDERMKIMAVM 6621

  Fly   788 TSSEDSN------RGDGPKNPVNWQTSADNTRLI--GHMILRKYYDGEDILGLKVNGGQPLATGG 844
            ..::..|      ||..|..|        :|.:|  |...|.: .:.:.|:.:..|     |...
 Worm  6622 AEADMQNVRKPIARGPPPMPP--------STSMIPPGMEGLSE-EERQKIMSVMAN-----AETD 6672

  Fly   845 SVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLHNKSADE---VYDII 906
            |.|...|..            :..:..|||.::.::.|..:.:.....||...|.:|   :..::
 Worm  6673 SSSSVITSR------------QPSRSPSVARMQPQLMPPQQAIPIIPPGLEGLSDEERHTIMSVM 6725

  Fly   907 DESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSV--PARRSSANFPHSGLASSMA 969
            .|:..:.....:.||.............:..||.     |...:  |.....:......:.|.|.
 Worm  6726 AEAEFEESRSQVPSRQPSRSPSFVNPQQSFHPIP-----SFEPIVPPGLEDLSEEERQKIMSVMM 6785

  Fly   970 GSAVVSSGGRYLQR---KAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPGSVSGSGLRQR--- 1028
            .:.|..|..:...|   ::|:|..|:    .|:|.|...|..|:..:.           ||:
 Worm  6786 NAEVEESRSQLPSRQPSRSPSVAMIQ----APAVPIIPSGMEDLPEAE-----------RQKIMS 6835

  Fly  1029 -GGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHG-------------PVHASASAS 1079
             ....:.|...||.|..::|..             ..|...||             .|.|.|...
 Worm  6836 VMAEAEIQNFVPSRSPSNYSMQ-------------PVPVIPHGLEDLSEAERQKILSVMAEAEID 6887

  Fly  1080 GSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQ 1144
            .:.   :...:|:.:...|          |||...|   |.......|.....:..|..|..:.|
 Worm  6888 SAK---IPSRSTSSYSMPP----------PLPQMSQ---PEITTGLEHSSEADMEFGRDSSRSHQ 6936

  Fly  1145 PIP-------IEGRLQLKLGYDQNTLQLIVTLVCATG-----LSLRQSGAGRNPYAKV----FLL 1193
            .||       .|.|.|:........|:.|:    .:|     :||.:...|..|...|    ...
 Worm  6937 VIPPGLENLSEEERQQIMSVMAHAELESII----PSGHIDQPISLPRGHTGFKPAGIVNEDELFE 6997

  Fly  1194 PDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGAND---------- 1248
            .:|..:.:..|:..|......:.:........|.|   .|||..:  .:|.||..
 Worm  6998 TERKQREESPTRESGYATSTSYERELAMGDEERMD---GLLEDII--RIREGARSRRDSRDEVLH 7057

  Fly  1249 -----------------------FIGEVVIDLAHHILDD---------EAEWYQLQ--------- 1272
                                   .:..|..::.....||         .||..|:|
 Worm  7058 RREEDPEVHTPEESSTAVVTDVPSVSPVTENVPEKQTDDFDFTYSDSRFAEIVQMQEEEEAGSLQ 7122

  Fly  1273 ----------------------PHQD------TSYLLRD-----------------------EGS 1286
                                  ||||      |:....|                       :..
 Worm  7123 KQKVDEKPRMWETVFDGDESELPHQDFVFNEPTTKKTSDFDFPKETDEVFEKPSEIQRIRVTKNH 7187

  Fly  1287 DV------DGLILT-----------PTDHLSPPSTMSRL---------------------SDSDT 1313
            ||      |.:|.|           |.|  |..|..||.                     ||||.
 Worm  7188 DVDMDEIYDNVIATEAPSSVSQRRQPVD--SETSVKSRTIQRGPTKPPPMIKITVEEETKSDSDE 7250

  Fly  1314 TSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVA--GMVARD------Y 1370
            .|..:.|...|...::   :..:|.|..|...|||..:.::..:..:::.  |.||.|      .
 Worm  7251 ESCSEDDEEYPDRVVA---APTAPAPTFEEVENERIRQEELGKEVLQQIMAFGEVANDEFDVQWA 7312

  Fly  1371 RTVSGIGQSYHNQASATG--------------------------------YYRRGGGNGVGSAIG 1403
            :|.:....|...:.:.|.                                :||. |.|....:..
 Worm  7313 KTTTSQTPSTSTKPTVTAPKRSDPIPIAPSQRSKEIEEERIRTEALEEEEFYRH-GHNPFLESPE 7376

  Fly  1404 PGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGY-RSTSPRRGSLSPPDDRYIDYPV-LPVHG 1466
            ...:|::......|.....:.|........||.|.. ...|...|:||..:.|.:.... |....
 Worm  7377 EDEVSINMEDVEYAEIARLYESANQTMRRPGPVYTITEDESEDDGTLSNSESRLVAREKRLMDKK 7441

  Fly  1467 SSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATP----------------TGS--------- 1506
            ::.:..:.||     ......|.|.....|.|.||||                |.|
 Worm  7442 TADSLMAKYQ-----KMKKVQAKQTTTASSTSVTATPAYAIINFSDLKTSTRTTDSNSYFETTKN 7501

  Fly  1507 --------PKKRQLPQV---------------------------------------PQTSRSA-- 1522
                    |||...|::                                       |.||.::
 Worm  7502 IPALEIKDPKKDIPPEISASIDKTMAEVDALLGQVYTNEKAIPNLLCFDQSNFSNHPPTSSASTS 7566

  Fly  1523 ------MLRDR---------------LGQDFDERLASGGRFGRHRTRQPHHQATYRSTG------ 1560
                  :|::.               ||...|. :........:.|..|  :...||.|
 Worm  7567 TADDLILLKNNNSSSPSFLLPLQSSVLGSQLDS-VRDDNERNENETTSP--RGLKRSPGMLLPSP 7628

  Fly  1561 ---------------------------------------MGGWERHYTGL----SDSDLHSMDAR 1582
                                                   |.|....|..|    .|.:|.:.|..
 Worm  7629 TSTSIFPMPPTAAESVGAAIGATTASMFGGISVADPPPTMDGLTNSYKWLQNIEDDGNLANNDMG 7693

  Fly  1583 MRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRG----------LSFPRNWRNL 1637
            .|...|:.|:        .|......|||::..||.:..|.||.|          ::.|
 Worm  7694 RRKLPSIPPN--------SSAFPPPTSVTTNVISTDTSMPSTSSGPAPTYVDDYNVTLP------ 7744

  Fly  1638 FGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQ--LAAL 1700
                        .:||.                   .:.|..||:  |....|.:|..|  :...
 Worm  7745 ------------SDPIV-------------------AESLLKGGS--LTRRHQHQQQHQAPVYIT 7776

  Fly  1701 AAADSPPISAGIGI----QPPHQVLVTDANSGQLVEQFYVEPGTMAEE--MMEPLDPHLHPHSVF 1759
            ::|..||.:||..|    :|      |.:.|....:.....||:.|..  ....::|.:...:.:
 Worm  7777 SSASRPPSAAGSNIFQESRP------TSSLSMYQNDVILSRPGSAASNYTTASTINPTILAGASY 7835

  Fly  1760 YSPSPHLPPQPFDIDIDTIYPPR--------------RSNGLKPNVQATAAAYPLP--------- 1801
            .|.:.....||.     ::..||              .||.::|::.:::....:|
 Worm  7836 SSKASSHIRQPV-----SVRSPRAQTGTTQTTAASGSASNSIRPSIGSSSVTTRVPNTLARVLLK 7895

  Fly  1802 -----------------------------------LLPSFEQFKRITTPITNFFRSSSPA----G 1827
                                               |||     ::....|.|..:...||    |
 Worm  7896 KELKDVLIQRKQRLEATEIEANQRHYKVQKMLITGLLP-----EKPEDDIPNIVKCDLPADLVRG 7955

  Fly  1828 VH--------------PHAHDHTSTTPSSLVGY-----VRDHQDKSCSHCQNGSQPVV---LSTH 1870
            ||              |..:.|    |:|:..:     ...|..||.: ||....|.|   :|..
 Worm  7956 VHISMQPPSPAVSAFSPRRYHH----PTSVASHQSHPSTFKHMSKSIA-CQADELPPVKPMISLR 8015

  Fly  1871 HTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNL 1935
            ..|                   |....|  |.|.|....|::...  |..:...:    .|.:..
 Worm  8016 TQL-------------------DMERRP--QLMTYVGKRSAETQT--ELANYESI----TPTVRY 8053

  Fly  1936 GVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKK 2000
            |.:|...........:|..:.|:....|.....:|.::::..||.........|         :.
 Worm  8054 GSIPRSSRERTASRRYREQQQQIYNQMPQNHNDLLEITKKYFEDYDRQLREFGE---------RA 8109

  Fly  2001 PKLERRRL-FHEGQSRSLDYDD------LHTKSWGRRRIRYEDEVMPSSG------DYPYPHSNP 2052
            .:..|||. ||:..    |.||      :|..:..:.|:....|::.::.      :...|.|:.
 Worm  8110 RRHSRRRFDFHDDD----DQDDMRKNQVMHELARRKERMCASCEILSTTDPIRTALNPNVPMSSD 8170

  Fly  2053 YSSYSPTAAMSRRY----GSETNIRQ-SYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVGWTR 2112
            |||:.|......|.    |:.:::|. :|...::....|.::|:                    .
 Worm  8171 YSSHVPHYGSLPRIDYPRGTRSDVRDFTYRQQHLPQQPPTNYSY--------------------N 8215

  Fly  2113 RGVAPSLFRGAHRQRGLAD---------------PRNHMSLDLQRTSQQKLYGPAAPYL------ 2156
            .|..|..|     :||.:|               ||:..:|..:.||...|..|.  ||
 Worm  8216 YGSLPRNF-----ERGFSDLPPIEIENEQSFGAPPRHRSNLGYESTSMFNLSDPV--YLGYDSIP 8273

  Fly  2157 ----KRRRNLPHPPS--AQNAHNFSPMEPG-SGMD---------------GLNAAA--------- 2190
                ::.|.....||  ||:..|.:.:..| .|.|               ||..:|
 Worm  8274 MVQHQQPRVYDQIPSGYAQDTTNLNSLNQGVRGSDMVSQYASYLNSQFQSGLQQSAQLPQPMIPI 8338

  Fly  2191 ---------------AGMVEQGNGMGSGGAHNTTSTHNSN--HHNS------QASSVSVSQSHNQ 2232
                           :.:|:|   |..|        :|||  ||:|      .|....::.::|
 Worm  8339 TRYDAPMSDPYVSSRSRLVDQ---MNQG--------YNSNQYHHHSTLLAPKSAQMTHIAPTYN- 8391

  Fly  2233 QLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASS 2297
            ||.|||.:..|:         |.:...||:|.::..|||              .|...|..|..|
 Worm  8392 QLAQQQGIPMQN---------TQMDPLMMSSGRIPSSSS--------------QVYSRNEMNYGS 8433

  Fly  2298 SSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQL-- 2360
            .        |.|.....:|        |:|...:.|....:..|.::......||||...||:
 Worm  8434 R--------PAQSSLFEYG--------NRRQYGAAPPPTYDVPNVSSASDWRTTQQQGLIQQMPM 8482

  Fly  2361 ---QQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTAN--ATNATTTATNPTTTTTNNTNEP 2420
               ||..||...:............|.|.........|::|  :|.:.:.|..|.        .|
 Worm  8483 QMQQQQHNTFDARWPKEDALSRMYATASRRRAQETALTSSNKISTGSRSYARRPI--------RP 8539

  Fly  2421 NATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYD-KDKNGAEEAGGSKSAEGAG 2484
            ::......||:..|...   |....:...:|....:|...:..:: .:..|....||.:...
 Worm  8540 SSYRNPEATNSMPDRHV---ARRTAENSRYDVKRILLTRSYKHHNIYNDLGVRVVGGKRQMN--- 8598

  Fly  2485 AEDKVDGSLSDTANDRKKGGGVDQERSPKGGSGMGKKSNSTSQLSATGRKRRMGFGK-------- 2541
                                              |:.|...|||.:|...:.:|..|
 Worm  8599 ----------------------------------GELSAYVSQLHSTANNQTLGQIKIGDEVVEW 8629

  Fly  2542 -----KGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVD 2601
                 :||....|.|......|:|...:||                         ....||...|
 Worm  8630 NGILLRGKTFEEVERIVNKSHGEIEMVIRT-------------------------YKNPSSGVYD 8669

  Fly  2602 AI---EQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSL-GDIQLSLCHQ-KG 2661
            .:   .....|....:|..|...:.      ::|:....::....|...|. |.||:||.:. ..
 Worm  8670 TLPLNRNTMRDDLSPDRVPPVPMHR------INGINNNSVLHHHTLSDSSCHGHIQVSLGYDGNS 8728

  Fly  2662 CLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFK---QS 2723
            .|..::||||||:.:.||:..|.|:|||||:.|::...|.:|.....:..|.:.|.|.::   .:
 Worm  8729 RLVAKIIRARGLKSRDQSRSAPNPFVKVYLLPGRKVSHKRRTRFVDSSCAPEWNQVLEYQVAPHT 8793

  Fly  2724 YTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGT------------TSLVS 2776
            .....|:.||. ||.|....:.:|..||.|.|.:..|....||.|.|:            |||..
 Worm  8794 LNTMFLEFTVC-DYQRDVDDLPLGNVQIPLADKSAINTGPRWYPLQGSYDQPIPQHYMNGTSLSQ 8857

  Fly  2777 CPTNIGLGSRRSS 2789
            .| :|...|:.|:
 Worm  8858 IP-SIAAASKHSA 8869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	31/172 (18%)
		PDZ_signaling	817..919	CDD:238492	16/104 (15%)
		C2A_RIM1alpha	1148..1272	CDD:175997	28/174 (16%)
		C2B_RIM1alpha	2633..2775	CDD:175994	47/158 (30%)
cla-1	NP_001294148.2	TrbI	728..>927	CDD:329122
		PDZ_signaling	8568..8658	CDD:238492	18/126 (14%)
		C2A_RIM1alpha	8714..8838	CDD:175997	41/124 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6337
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860