DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rim and RIMS4

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	NP_001192246.1	Gene:	RIMS4 / 140730	HGNCID:	16183	Length:	270	Species:	Homo sapiens

Alignment Length:	278	Identity:	103/278 - (37%)
Similarity:	150/278 - (53%)	Gaps:	46/278 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  2523 NSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEV-----LPGDITRELRTGGGLGVSLGGAGGAAG 2582
            ||.....|.|..||:    ||    .:.||.|.     :|   :|.||...  ..|:..:..:.|
Human    25 NSFDDEDAEGDSRRL----KG----AIQRSTETGLAVEMP---SRTLRQAS--HESIEDSMNSYG 76

  Fly  2583 GSGGAGGGGLSRGSSSEVDAIEQFFGDGAGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAP 2647
            ..|....||:                          .|.:|...::|:..:||.|.||||.|...
Human    77 SEGNLNYGGV--------------------------CLASDAQFSDFLGSMGPAQFVGRQTLATT 115

  Fly  2648 SLGDIQLSLCHQKGCLEVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDP 2712
            .:||:::.|..:.|.|||::|:||||..|..||.|||.|:|.||:....|:.|.||..||::|||
Human   116 PMGDVEIGLQERNGQLEVDIIQARGLTAKPGSKTLPAAYIKAYLLENGICIAKKKTKVARKSLDP 180

  Fly  2713 LYQQQLVFKQSYTGCILQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSC 2777
            ||.|.|:|.:|..|.:||:.|||:|||:|:|.|||||:::|::|:|:.:.:||||||.|:|:|..
Human   181 LYNQVLLFPESPQGKVLQVIVWGNYGRMERKQFMGVARVLLEELDLTTLAVGWYKLFPTSSMVDP 245

  Fly  2778 PTNIGLGSRRSSIASLDS 2795
            .|  |...|::|..||:|
Human   246 AT--GPLLRQASQLSLES 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600
		PDZ_signaling	817..919	CDD:238492
		C2A_RIM1alpha	1148..1272	CDD:175997
		C2B_RIM1alpha	2633..2775	CDD:175994	72/141 (51%)
RIMS4	NP_001192246.1	C2	101..246	CDD:417471	73/144 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143511
Domainoid	1	1.000	144	1.000	Domainoid score	I4609
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm40596
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950