DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and Rims2

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	XP_017171859.1	Gene:	Rims2 / 116838	MGIID:	2152972	Length:	1649	Species:	Mus musculus

Alignment Length:	2862	Identity:	625/2862 - (21%)
Similarity:	894/2862 - (31%)	Gaps:	1356/2862 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IENVLM-RQKQEEEKQNEIMRRKQDEVVTLEMQIRQRSEQQKKAGVEL--------DA-TCHICL 72
            :.|||. :|||..||:.:         ..|..|.....||.||.|.|.        || ||.||.
Mouse    51 VNNVLQPQQKQPNEKEPQ---------TKLHQQFEMYKEQVKKMGEESQQQQEQKGDAPTCGICH 106

  Fly    73 KTKFADGVGHICHYCNIRCCARCGGKVTLRSNK----VIWVCILCRKKQELLSKTGQWI----NK 129
            |||||||.||.|.||..:.||||||:|:|||||    |:|||.||||:||:|:|:|.|.    :.
Mouse   107 KTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKEDKVVMWVCNLCRKQQEILTKSGAWFYNSGSN 171

  Fly   130 TAAQQDGFIRR------IEPDGSSDISQHPIVD--PHDTTDKRPKLERTRSAAEKENLPMQ---R 183
            |..|.|..:.|      ...:..:.:.:.|...  |.|.:  .|.:|:.|:    ..|..|   :
Mouse   172 TLQQPDQKVPRGLRNEEAPQEKKAKLHEQPQFQGAPGDLS--VPAVEKGRA----HGLTRQDTIK 230

  Fly   184 AGSMLRRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQ 248
            .||.::.|.: .:.|::|:.|       |.:|..|..::.|.::|.......|...
Mouse   231 NGSGVKHQIA-SDMPSDRKRS-------PSVSRDQNRRYEQSEEREDYSQYVPSDG--------- 278

  Fly   249 QQPRSGGAYPD----DDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMP 309
            ..|||...|.|    .:|::|:                   :|.|.....|.::..:|.:::::.
Mouse   279 TMPRSPSDYADRRSQREPQFYE-------------------EPGHLNYRDSNRRGHRHSKEYIVD 324

  Fly   310 QQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQ-----QHPHPHS 369
            .:...|..::.:|:::::                         |.|:....|.     ..|.|:.
Mouse   325 DEDVESRDEYERQRREEE-------------------------YQARYRSDPNLARYPVKPQPYE 364

  Fly   370 QQQQHHQQM---QHQHGQSVPQMGGYQKPPPLTRNLTISGGHAMDS-------SAYSQQQQQQQR 424
            :|.:.|.::   :|:...|               :::::.....||       ...|:|:...:|
Mouse   365 EQMRIHAEVSRARHERRHS---------------DVSLANAELEDSRISLLRMDRPSRQRSVSER 414

  Fly   425 RALAGSQYASQQQRSFSSSEEEFQHQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNER 489
            ||      |.:.|||:|      ..:...|||.      |.|.    |..::..|...:||....
Mouse   415 RA------AMENQRSYS------MERTREAQGQ------SSYP----QRTSNHSPPTPRRSPIPL 457

  Fly   490 DLLSSGGGGGGGVGGADFRHLSHATQRLYASADQRDRYELQLQHR-ERLEQYPLTRTARLDVQQR 553
            |                             ..|.|....|:.||. :.......|:..:::...|
Mouse   458 D-----------------------------RPDMRRADSLRKQHHLDPSSAVRKTKREKMETMLR 493

  Fly   554 N-SLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAPPL--AAAGGGGSSSSSTTSSSYYPQSK 615
            | ||:....|                      :.|..||.  .:..||.....|.:||.....|.
Mouse   494 NDSLSSDQSE----------------------SVRPPPPRPHKSKKGGKMRQVSLSSSEEELAST 536

  Fly   616 PQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAY 680
            |:..          |.....:.|.:.:...|:|....:.|::|.|
Mouse   537 PEYT----------SCDDVELESESVSEKGDSQKGKRKTSEQGVL-------------------- 571

  Fly   681 WDEPATSSSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATIL 745
                         .||...:||: ||.:.:..|..|..:
Mouse   572 -------------SDSNTRSERQ-KKRMYYGGHSLEEDL-------------------------- 596

  Fly   746 SSGKSLDAVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSAD 810
                          :||          :...||||:||.|:.|.:|:.:..|  |:||.||.|.|
Mouse   597 --------------EWS----------EPQIKDSGVDTCSSTTLNEEHSHSD--KHPVTWQPSKD 635

  Fly   811 NTRLIGHMILRKYY-------DGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKV 868
            ..||||.::|.|..       |...:|||||.||:...:|..               | |.:.||
Mouse   636 GDRLIGRILLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRL---------------C-AFITKV 684

  Fly   869 KRGSVADLEGRIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSS 933
            |:||:||..|.:|||||:||||||.|...:.:|||:||.||:.:.||||:||||||
Mouse   685 KKGSLADTVGHLRPGDEVLEWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIG--------- 740

  Fly   934 ANVSPISGASGGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKP 998
                           .:|....|.   |:.|.||.:.         :..:|          .|:|
Mouse   741 ---------------DIPRIPDST---HAQLESSSSS---------FESQK----------MDRP 768

  Fly   999 SVLITSPGSP----DIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSST 1059
            |:.:|||.||    |:...:|  |.:|...|.:|
Mouse   769 SISVTSPMSPGMLRDVPQFLS--GQLSSQSLSRR------------------------------- 800

  Fly  1060 SSVHAPASAHGPVHASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHL 1124

Mouse   801 ----------------------------------------------------------------- 800

  Fly  1125 QGHGVGGGIGMGSGSGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAK 1189
                             ||..:|   |:|:||.:|:...|||||::.|..|..|:.|..||||.|
Mouse   801 -----------------TTPFVP---RVQIKLWFDKVGHQLIVTILGAKDLPSREDGRPRNPYVK 845

  Fly  1190 VFLLPDRSHKSKRRTKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGE 1252
            ::.|||||.|:|||||||..|.||:|.|||:||.:.|.:...|:||:||||.  ||...::|:||
Mouse   846 IYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGE 910

  Fly  1253 VVIDLAHHILDDEAEWYQLQPHQDTSYLLRDEGSDVDGLIL------TPTDHLSPPSTMSRLSDS 1311
            ::|:|...:||||..||:||.|            ||..|.|      .|...|...|...||.:.
Mouse   911 ILIELETALLDDEPHWYKLQTH------------DVSSLPLPRPSPYLPRRQLHGESPTRRLQNK 963

  Fly  1312 DTTSDCDIDGMTPGASISSMGSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGI 1376
                           ::.|..|                        |.||::.....||....|:
Mouse   964 ---------------ALCSYNS------------------------GSKRISDSEVSDYDCEDGV 989

  Fly  1377 GQSYHNQASATGYYRRGGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRS 1441
            |        ....||..|.:...|.:......:|  |:..:||...|...|.|..        ||
Mouse   990 G--------VVSDYRHNGRDLQSSTLSVPEQVMS--SNHCSPSGSPHRVDVIGRT--------RS 1036

  Fly  1442 TSPRRGSLSPPDDRYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGS 1506
            .||   |..||..|                 :|.||
Mouse  1037 WSP---SAPPPQSR-----------------NVEQG----------------------------- 1052

  Fly  1507 PKKRQLPQVPQTSRSAMLRDRLGQDFDERLASGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGL 1571
                                                         |:.| |:||      ||..:
Mouse  1053 ---------------------------------------------HRGT-RATG------HYNTI 1065

  Fly  1572 SDSDLHSMDARMRPRHSLSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRN 1636
            |..|.|    |:...| .|.|:|                              |..|:.||:
Mouse  1066 SRMDRH----RVMDDH-YSSDRD------------------------------SHFLTLPRS--- 1092

  Fly  1637 LFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALA 1701
                |:|       :.|.    ||...||       ||:
Mouse  1093 ----RHS-------QTID----HHHRDGR-------DCE-------------------------- 1109

  Fly  1702 AADSPPISAGIGIQPPHQVLVTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHL 1766
            |||..|
Mouse  1110 AADRQP----------------------------------------------------------- 1115

  Fly  1767 PPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPH 1831
                        |...||...:|.::.|..           :.:....|.||..||.      |.
Mouse  1116 ------------YHRSRSTEQRPLLERTTT-----------RSRSSERPDTNLMRSM------PS 1151

  Fly  1832 AHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHP 1896
            .....|..||..:         |.||.:.||...
Mouse  1152 LMTGRSAPPSPAL---------SRSHPRTGSVQT------------------------------- 1176

  Fly  1897 HPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATP 1961
                       .|||                                   ||...||.|   ..|
Mouse  1177 -----------SPSS-----------------------------------TPGTGRRGR---QLP 1192

  Fly  1962 APPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTKS 2026
            ..||                                  |..|||:           |.|....::
Mouse  1193 QLPP----------------------------------KGTLERK-----------DVDSTRKRN 1212

  Fly  2027 WGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSH 2091
            .|...|...:..|            ..:.|...|      ||:..:.|.|            ||
Mouse  1213 TGAMDIEERNRQM------------KLNKYKQVA------GSDPRLEQDY------------HS- 1246

  Fly  2092 FLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYL 2156
                       .|.|  ||
Mouse  1247 -----------KYRS--GW---------------------------------------------- 1252

  Fly  2157 KRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQA 2221
                                 :|..|.|                       |.||.:|:...|..
Mouse  1253 ---------------------DPHRGAD-----------------------TVSTKSSDSDVSDV 1273

  Fly  2222 SSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLV 2286
            |:||.:.|
Mouse  1274 SAVSRTSS--------------------------------------------------------- 1281

  Fly  2287 VGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDAT 2351
                 |:..||:|:.:.|...|:..:::..|| .:.::..:.|...|     .|....:|.:..:
Mouse  1282 -----ASRFSSTSYMSVQSERPRGNRKISFSP-LVQDHGAQTPVQPP-----LIPLGPDLNVFTS 1335

  Fly  2352 QQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNN 2416
            :.|::|..:       :.:|      ||.:|:.|.:..:.
Mouse  1336 KMQNRQMGV-------SGKN------LTKSTSISGDMCSL------------------------- 1362

  Fly  2417 TNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAE 2481

Mouse  1363 ----------------------------------------------------------------- 1362

  Fly  2482 GAGAEDKVDGSLSDTANDRKKGGGVDQERSPKGGS-----GMGKKSNSTSQLSATGRKRRMGFGK 2541
                 :|.|||.||||.......| .:.||..|..     |:.:||.|.||||.|     .|.||
Mouse  1363 -----EKNDGSQSDTAVGALGTSG-KKRRSSIGAKMVAIVGLSRKSRSASQLSQT-----EGGGK 1416

  Fly  2542 KGKNSFTVHRSEEVLPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQF 2606
            |.::  ||.||.|.             ||.|.:              ...::|.:|.|..
Mouse  1417 KLRS--TVQRSTET-------------GLAVEM--------------RNWMTRQASREST----- 1447

  Fly  2607 FGDG------AGGERFSPSLR--NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCL 2663
              ||      :.|....|.:|  :|...::|:|||||.||||||.|..|::||||:.:..:||.|
Mouse  1448 --DGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGDIQVGMMDKKGQL 1510

  Fly  2664 EVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCI 2728
            |||:||||||..|..||.||||||||||:....|:.|.||..||:||:|||||.|.|::|..|.:
Mouse  1511 EVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLEPLYQQLLSFEESPQGRV 1575

  Fly  2729 LQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASL 2793
            |||.|||||||::.|.|||||||:||:|.|||:||||:|||..:|||. ||...| :||:|.:||
Mouse  1576 LQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPPSSLVD-PTLAPL-TRRASQSSL 1638

  Fly  2794 DS 2795
            :|
Mouse  1639 ES 1640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	59/121 (49%)
		PDZ_signaling	817..919	CDD:238492	44/108 (41%)
		C2A_RIM1alpha	1148..1272	CDD:175997	62/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	89/141 (63%)
Rims2	XP_017171859.1	PHD_SF	<118..168	CDD:389947	29/49 (59%)
		PDZ_signaling	654..735	CDD:238492	42/96 (44%)
		C2A_RIM1alpha	807..930	CDD:175997	62/122 (51%)
		PHA02666	1040..>1141	CDD:222914	44/366 (12%)
		C2B_RIM1alpha	1480..1625	CDD:175994	91/145 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833671
Domainoid	1	1.000	144	1.000	Domainoid score	I4578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D109268at2759
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm42672
orthoMCL	1	0.900	-	-		OOG6_103451
Panther	1	1.100	-	-	O	PTHR12157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2752
SonicParanoid	1	1.000	-	-		X2115
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930