DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and Rims1

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	XP_036009856.1	Gene:	Rims1 / 116837	MGIID:	2152971	Length:	1652	Species:	Mus musculus

Alignment Length:	2927	Identity:	612/2927 - (20%)
Similarity:	869/2927 - (29%)	Gaps:	1434/2927 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMR---------------------------- 37
            |.|:|||||||..||..|..|:.|||:||||:..:::
Mouse    19 MQELPDLSHLTEEERNIIMAVMDRQKEEEEKEEAMLKCVVRDMAKPAACKTPRNAESQPHQPPLN 83

  Fly    38 --------RK-------QDEVVTLEMQIRQRSEQQKKAGVEL---------DA-TCHICLKTKFA 77
                    ||       .|....|..|.....||.:|.|.|.         || ||.||.|||||
Mouse    84 IFRCVCVPRKPSSEEGGPDRNWRLHQQFESYKEQVRKIGEEARRYQGEHKDDAPTCGICHKTKFA 148

  Fly    78 DGVGHICHYCNIRCCARCGGKVTLRSN---------------KVIWVCILCRKKQELLSKTGQWI 127
            ||.||:|.||..:.||||||:|:||||               ||:|||.||||:||:|:|:|.|.
Mouse   149 DGCGHLCSYCRTKFCARCGGRVSLRSNNEDKVVFLLRGDTISKVMWVCNLCRKQQEILTKSGAWF 213

  Fly   128 NKTAAQ---QDGFIRRIEPDGSSDISQHPIVDPHDTTDKRPKL-ERTRSAAEKENLPMQRAGSML 188
            ..:..|   |||.:........|::.:          :|:.:| ||:||     ..|:..| ::.
Mouse   214 FGSGPQQPSQDGTLSDTATGAGSEVPR----------EKKARLQERSRS-----QTPLSTA-AVS 262

  Fly   189 RRQYSQQEQPTNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRS 253
            .:..:....|.:|...|         .|.||....:|:|.:|.:...|::.::..|:.:|.  ..
Mouse   263 SQDTASHGAPLDRNKGA---------EPSQQALGPEQKQASRSRSEPPRERKKAPGLSEQN--GK 316

  Fly   254 GGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQ 318
            ||                           .:.:.:..|:|..|                   |.:
Mouse   317 GG---------------------------QKSERKRVPKSVVQ-------------------PGE 335

  Fly   319 HSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSYHAQIHQQPQQHPHPHSQQQQHHQQMQHQHG 383
            .:..::::::..:  ..|.::.:.|.:..::::....::.:         .::|:..::.|.::
Mouse   336 GTADERERKERRE--TRRLEKGRSQDYPDRLEKREDGRVAE---------DEKQRKEEEYQTRY- 388

  Fly   384 QSVPQMGGYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQ 448
            :|.|.:..|....||                     ::||.|..|....|..::|   .|:....
Mouse   389 RSDPNLARYPVKAPL---------------------EEQQMRMHARVSRARHERR---HSDVALP 429

  Fly   449 HQLLAAQGAVTVTAGSDYDGGRLQVRTSLDPWRQQRSLNERDLLSSGGGGGGGVGGADFRHLSHA 513
            |...||..:...|||.     |.|....:.|                                ..
Mouse   430 HTEAAAAVSAETTAGK-----RAQTTARVSP--------------------------------PE 457

  Fly   514 TQRLYASADQRDRYELQLQH---------------RERLEQYPLTRTARLDVQQRNSLNRSNHER 563
            :.|..|.|.|.     ..:|               ..|:.: ||.:..|||......|.::..|:
Mouse   458 SPRARAPAAQP-----PAEHGPPPPRPAPGPAEPPEPRVPE-PLRKQGRLDPGSAVLLRKAKREK 516

  Fly   564 QFSGGGAGVGPGGAGGGGAAGAYRRAPPLAAAGGGGSSSSSTTSSSYYPQ-SKPQIVIGPGSGYD 627
                              |....|           ..|.||..|.|..|. .||.   .|..|..
Mouse   517 ------------------AESMLR-----------NDSLSSDQSESVRPSPPKPH---RPKRGGK 549

  Fly   628 RGSGSMASMASAAAAT-----AADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATS 687
            |...|::|......:|     ..|.:.::...|::|.|                  .||.:|||
Mouse   550 RRQMSVSSSEEEGVSTPEYTSCEDVELESESVSEKGDL------------------DYWLDPAT- 595

  Fly   688 SSSSAAQDSRRFTERRIKKTVRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLD 752
                                    .|..|.|.::|
Mouse   596 ------------------------WHSRETSPISS------------------------------ 606

  Fly   753 AVGVGGADWSRWEAERQGSQDSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGH 817
                                                            :||.||.|.:..||||.
Mouse   607 ------------------------------------------------HPVTWQPSKEGDRLIGR 623

  Fly   818 MILRKY----YDGEDILGLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEG 878
            :||.|.    .:...:|||||.||:....                |..||.:.|||:||:||:.|
Mouse   624 VILNKRTTMPKESGALLGLKVVGGKMTDL----------------GRLGAFITKVKKGSLADVVG 672

  Fly   879 RIRPGDEILEWNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGAS 943
            .:|.|||:|||||:.|...:.:|||:||.||:.:.|||:|||||||
Mouse   673 HLRAGDEVLEWNGKPLPGATNEEVYNIILESKSEPQVEIIVSRPIG------------------- 718

  Fly   944 GGSANSVPARRSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSP 1008
                 .:|....|::.|....:||.....:                      ::||:.:.||.||
Mouse   719 -----DIPRIPESSHPPLESSSSSFESQKM----------------------ERPSISVISPTSP 756

  Fly  1009 DIHTSVSGPGSVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVH 1073

Mouse   757 ----------------------------------------------------------------- 756

  Fly  1074 ASASASGSAPGGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSG 1138
               .|...||
Mouse   757 ---GALKDAP------------------------------------------------------- 763

  Fly  1139 SGTTTQPIPIEGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRR 1203
                 |.:|  |:|.:||.||:...||||.::.||.|..|..|..||||.|::.|||||.|||||
Mouse   764 -----QVLP--GQLSVKLWYDKVGHQLIVNVLQATDLPPRVDGRPRNPYVKMYFLPDRSDKSKRR 821

  Fly  1204 TKTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLAHHILDDEA 1266
            ||||....||:|.||||||.:.|.|...|:||:|:||.  |:...::|:||::|:|...:||||.
Mouse   822 TKTVKKLLEPKWNQTFVYSHVHRRDFRERMLEITVWDQPRVQDEESEFLGEILIELETALLDDEP 886

  Fly  1267 EWYQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSM 1331
            .||:||.|.::|..|.....      ..|..|:...|:..:|..|...||.||.
Mouse   887 HWYKLQTHDESSLPLPQPSP------FMPRRHIHGESSSKKLQRSQRISDSDIS----------- 934

  Fly  1332 GSSASPPPLLELDLNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGN 1396
                                                 ||....|||
Mouse   935 -------------------------------------DYEVDDGIG------------------- 943

  Fly  1397 GVGSAIGPGGMSLSQRSHSA----APSD---GYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDD 1454
                .:.|.|...|.|...|    .|..   .:|.|              ||.||.||     ||
Mouse   944 ----VVPPVGYRASARESKATTLTVPEQQRTTHHRS--------------RSVSPHRG-----DD 985

  Fly  1455 RYIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTS 1519
            :                                                 |.|:.| ||.||
Mouse   986 Q-------------------------------------------------GRPRSR-LPNVP--- 997

  Fly  1520 RSAMLRDRLGQDFDERLASGGRFGRHRTRQP--HHQAT-----YRSTGMGGWERHYTGLSDSDLH 1577
                    |.:..||...:      .|:|.|  ||.|:     :||...   |..|:...||:|.
Mouse   998 --------LQRSLDEIHPT------RRSRSPTRHHDASRSLADHRSRHA---ESQYSSEPDSELL 1045

  Fly  1578 SMDARMRPRHS--------LSPDKDFMGEFGDSDMESVVSVTSSAFSTQSERPRTSRGLSFPRNW 1634
            .:....|.|.:        |.|..|                .:.:.||...||.||
Mouse  1046 MLPRAKRGRSAECLHMTSELQPSLD----------------RARSASTNCLRPDTS--------- 1085

  Fly  1635 RNLFGVRNSFLGGAGGEPITGLRLHHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAA 1699
                                   ||..|..|..        :.|
Mouse  1086 -----------------------LHSPERERGR--------WSP--------------------- 1098

  Fly  1700 LAAADSPPISAGIGIQPPHQVLVTDANSGQLVE---QFYVEPGTMAEEMMEPLDPHLHPHSVFYS 1761
             :.|...|.|..|.||  |.....|.:|.:...   |.....||.:
Mouse  1099 -SLARRRPASPRIQIQ--HASPENDRHSRKSERSSIQKQSRKGTAS------------------- 1141

  Fly  1762 PSPHLPPQPFDIDIDTIYPPRRSNGLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPA 1826
                        |.|.:.||..|.          ..|.:|         |.|
Mouse  1142 ------------DADRVLPPCLSR----------RGYAIP---------RAT------------- 1162

  Fly  1827 GVHPHAHDHTSTTPSSLVGYVRDHQDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCL 1891
                                               .|||:...|.|...::
Mouse  1163 -----------------------------------DQPVIRGKHTTRSRSS-------------- 1178

  Fly  1892 ADAHPHPQHQPMGYGEPPSSDPAMCGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARG 1956
                   :|         ||...:|                                :.|..|.|
Mouse  1179 -------EH---------SSIRTLC--------------------------------SMHHLAPG 1195

  Fly  1957 QMATPAPPPTQSVLRLSRQLSEDALVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDD 2021
            ..|.|:|..|    |..||                ..||                 ||...|
Mouse  1196 GSAPPSPLLT----RTHRQ----------------GSPT-----------------QSPPAD--- 1220

  Fly  2022 LHTKSWGRRRIRYEDEVMPSSGDYPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHP 2086
               .|:|.||.|...:|...||                           :|.|:
Mouse  1221 ---TSFGSRRGRQLPQVPVRSG---------------------------SIEQA----------- 1244

  Fly  2087 LSHSHFLVTDDKIVTITYDSDVGWTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGP 2151
                 .||.:                                            :||.|.|:
Mouse  1245 -----SLVVE--------------------------------------------ERTRQMKM--- 1257

  Fly  2152 AAPYLKRRRNLPHPPSAQNAHNFSPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNH 2216
                              ..|.|                    :|..|.||
Mouse  1258 ------------------KVHRF--------------------KQTTGSGS-------------- 1270

  Fly  2217 HNSQASSVSVSQSHNQQLQQQQQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAA 2281
                          :|:|..:|..:....:.:.:....|.:          |||.......||
Mouse  1271 --------------SQELDHEQYSKYNIHKDQYRSCDNASA----------KSSDSDVSDVSA-- 1309

  Fly  2282 AGHLVVGGTNANNASSSSFANPQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNL 2346
                :...::.:..||:||.:.|...|:                .|..|.||:.....:.
Mouse  1310 ----ISRASSTSRLSSTSFMSEQSERPR----------------GRISSFTPKMQGRRMG----- 1349

  Fly  2347 TLDATQQQSQQQQLQQPPNTCTNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTT 2411
                                                            |:..|...:|:.:....
Mouse  1350 ------------------------------------------------TSGRAIIKSTSVSGEIY 1366

  Fly  2412 TTTNNTNEPNATTTTTTTNANADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGG 2476
            |..:|
Mouse  1367 TLEHN------------------------------------------------------------ 1371

  Fly  2477 SKSAEGAGAEDKVDGSLSDTANDRKKGGGVDQER--SPKGGSGMGKKSNSTSQLSAT--GRKRRM 2537
                         |||.||||......||..:..  |.|..:.:.::|.||||||.|  |.|
Mouse  1372 -------------DGSQSDTAVGTVGAGGKKRRSSLSAKVVAIVSRRSRSTSQLSQTESGHK--- 1420

  Fly  2538 GFGKKGKNSFTVHRSEEV-LPGDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVD 2601
                  |...|:.||.|. :..::.:.:|..                         ||.|:.  .
Mouse  1421 ------KLKSTIQRSTETGMAAEMRKMVRQP-------------------------SRESTD--G 1452

  Fly  2602 AIEQFFGDG---AGGERFSPSLRNDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCL 2663
            :|..:..:|   ..|.|..|    |...::|:|||||.||||||.|..|::||||:.:..:||.|
Mouse  1453 SINSYSSEGNLIFPGVRVGP----DSQFSDFLDGLGPAQLVGRQTLATPAMGDIQIGMEDKKGQL 1513

  Fly  2664 EVEVIRARGLQQKAQSKMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCI 2728
            ||||||||.|.||..||..|||||||||:....|:.|.||..||:||||||||.|||.:|..|.:
Mouse  1514 EVEVIRARSLTQKPGSKSTPAPYVKVYLLENGACIAKKKTRIARKTLDPLYQQSLVFDESPQGKV 1578

  Fly  2729 LQITVWGDYGRIEKKVFMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASL 2793
            ||:.|||||||::.|.|||||||:|::|:||::||||||||..:|||. ||...| :||:|.:||
Mouse  1579 LQVIVWGDYGRMDHKCFMGVAQILLEELDLSSMVIGWYKLFPPSSLVD-PTLTPL-TRRASQSSL 1641

  Fly  2794 DS 2795
            :|
Mouse  1642 ES 1643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	68/185 (37%)
		PDZ_signaling	817..919	CDD:238492	41/105 (39%)
		C2A_RIM1alpha	1148..1272	CDD:175997	63/125 (50%)
		C2B_RIM1alpha	2633..2775	CDD:175994	89/141 (63%)
Rims1	XP_036009856.1	FYVE_like_SF	<154..220	CDD:333710	29/65 (45%)
		DUF601	225..>327	CDD:282493	24/155 (15%)
		PDZ_signaling	628..713	CDD:238492	39/100 (39%)
		C2A_RIM1alpha	766..892	CDD:175997	64/127 (50%)
		C2B_RIM1alpha	1483..1628	CDD:175994	91/145 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833669
Domainoid	1	1.000	144	1.000	Domainoid score	I4578
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	614	1.000	Inparanoid score	I898
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000817
OrthoInspector	1	1.000	-	-		otm42672
orthoMCL	1	0.900	-	-		OOG6_103451
Panther	1	1.100	-	-	LDO	PTHR12157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2752
SonicParanoid	1	1.000	-	-		X2115
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920