DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rim and pcloa

DIOPT Version :9

Sequence 1:	NP_001247163.1	Gene:	Rim / 42150	FlyBaseID:	FBgn0053547	Length:	2798	Species:	Drosophila melanogaster
Sequence 2:	XP_009298508.1	Gene:	pcloa / 100148002	ZFINID:	ZDB-GENE-030131-8115	Length:	4313	Species:	Danio rerio

Alignment Length:	1878	Identity:	387/1878 - (20%)
Similarity:	642/1878 - (34%)	Gaps:	556/1878 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EMPDLSHLTPHERMQIENVL-----MRQ----KQEEEKQNEIMRRKQ---------DEVVTLEMQ 49
            |..::......|::.::..|     |:|    :||||:|..:|.:|:         :::..|:.|
Zfish  2540 ERQEIQRFREQEQLLVQKELEELQAMKQQILCQQEEERQAHLMMQKETYAQQQEQLEQIQRLQEQ 2604

  Fly    50 IRQRSEQQK-----------KAGV-----ELDATCHICLKTKFADGVGHICHYCNIRCCARCGGK 98
            :||:.|:||           :|.|     ::|:.|    :|...|....          |...|:
Zfish  2605 LRQQLEEQKFRQMYPGEVLPEALVVTGERKMDSGC----QTDEEDNTEK----------AYTAGR 2655

  Fly    99 VTLRSNKVIWVCILC--------------RKKQELLSKTG---------QWINKTAAQQD-GFIR 139
            ....:.|.:..|:..              |:.:....|.|         |.:.:.:.|.| |.:|
Zfish  2656 KKKTTKKSVDSCVQTDDEDQDEWEVPARGRRSRPRGGKNGMAERGAVSVQALTEISVQTDSGTLR 2720

  Fly   140 --------RIE-PDGSS-----------DISQHPIVDPHDTT-------DKRPKLERTRSAAEKE 177
                    |:: ||...           ||.|.|::....:|       .|.||:..:
Zfish  2721 GHSVQVDARVDYPDSDRTSSPKRRPIPLDIGQSPLLKADASTLQVAPGPPKSPKVLYS------- 2778

  Fly   178 NLPMQRAGSMLRR-QYSQQEQP-----TNRRLSASDSGMDPVMSPGQQMQHHQQQQRARMQPMNP 236
              |:....|..:. :|...|:|     ..|..|.:|....|..||  :.....|:..:..:||:|
Zfish  2779 --PISPCVSPSKSLEYLSYEKPLGETSPQRIRSVTDLSKGPPTSP--RAPKVIQRSMSDPKPMSP 2839

  Fly   237 QQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDGLMRQHPHLAHPSQVQPQHTPQSHSQQQQSQ 301
            ...::.....|..:..|....|...|   .|....:.|..|:  .||:.:..:..|:......::
Zfish  2840 TAEERAAANFQYSESYSAKGSPSGTP---SGTQKKVKRTLPN--PPSEEEAANAGQAAYSTGSAR 2899

  Fly   302 HQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAARQQQHQQQQHQQQVQQSY-HAQIHQQPQQHP 365
            .:.............|...::....::.|.:...:|.:..:::.:...:..| ...|:::
Zfish  2900 RRLCRSTNMARAKILQDIDRELDLVERESSKLRKKQAELDEEEKEIDAKLRYLEMGINRR----- 2959

  Fly   366 HPHSQQQQHHQQMQHQHGQSVPQMGGYQKPPPL-----TRNLTISGGHAMDS------------- 412
              .....:..::.:..:.|||.:...|.....:     ||.....|||.::.
Zfish  2960 --KDALLKEREKRERAYLQSVAEDRDYMSDSEVSNIRETRGGEDIGGHGLERPRTAPQSELDEFV 3022

  Fly   413 ---------SAYSQQQQQQQRRALAGSQYASQQQRSFSS------SEEEFQHQLL-----AAQGA 457
                     ..|||.|..|.:::|...|...|.|..:||      |:::..||:|     |.|.|
Zfish  3023 PPQTKHDQYGKYSQYQYSQYQQSLYQPQSPYQSQSIYSSVPSLTASQQQSYHQMLLLQQKARQQA 3087

  Fly   458 VTVT------AGSDYD-----GGR---------LQVR------------------TSLDPWRQQR 484
            ..::      ..|.||     ||:         |:.|                  :.||..:..|
Zfish  3088 ALLSELDSTKIASSYDTSSYLGGKYSNHLDLHSLEDRAGSMAVSPMSNVSADSFYSDLDQHQTPR 3152

  Fly   485 SL----NERDLLSSGGGGGGGVGGADFRHLSHATQRL-YASADQRDRYELQLQHRERLEQY---- 540
            |.    :..:|..|.|.......|...|.|:.|.:.| :|:||....|   |....||..|
Zfish  3153 SYMLLEDAAELAKSTGSLSSTSYGIAERELAKAERLLRHAAADVSSDY---LGSSSRLHSYGKAQ 3214

  Fly   541 ----PLTRTARLDV--QQ-----RNSLNRSNHERQFSGGGAGVGPGGAGGGGAAGAYRRAP---- 590
                |:.....|.:  ||     |.|...:....|.:|......|   ..|.::|.||..|
Zfish  3215 DEEDPMEEPFELKLLKQQLKQEFRRSTGGTESLEQLAGLSHHYTP---STGVSSGGYRAYPKTEK 3276

  Fly   591 -PLAAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAATAADAQGQ---- 650
             .::.......::....:|..|.:.|....||..|......|.....:|...::::..:..
Zfish  3277 YSISRLTLEKQAAKQLPTSMLYQKHKNTSNIGKYSSMQDSRGLETDYSSYLGSSSSSPRSSRLMQ 3341

  Fly   651 -----------AARNSQRGGLLGATRGG----GGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFT 700
                       |.:....|..|||...|    |.|.::|....:...|.::..|.|.::.|.|.:
Zfish  3342 DEITFGLRKNIAEQQKYLGSTLGANLAGSLNLGQSLNLSPGMRSSLGEDSSYPSGSRSRPSSRPS 3406

  Fly   701 -----ERRIKK-----TVRFDAHDEEASILAS----------SSLP---------PVTA------ 730
                 :..||:     ::|..|..|.:|..::          :|||         |:.|
Zfish  3407 SVYGLDLSIKRDLSSSSLRLKAEGEASSETSAFQTPSGRSKPTSLPIVQSGRGRIPIVAQNSEEE 3471

  Fly   731 -ILPSTAVDVGAATILSSGK----SLDAVGVGGADWSRWEAERQGSQDSATKDSGI----DTSST 786
             .|......:|.|. .|:|.    |.|:....|:..|..|:::|..::..::..|.    |...|
Zfish  3472 SPLSPVGQPMGMAR-ASAGPLPPISADSRDQFGSCMSLQESQQQHLREDPSRGRGYVLMDDLQGT 3535

  Fly   787 FTSSEDSNRG------DGPKNPVNWQTSADNTRLIGHMILRKYYDG--EDILGLKVNGGQ----- 838
            .:.||..:..      |.|.|.....|:|.:.|........|..||  |:..|::...|:
Zfish  3536 MSDSEALSESLVGLSRDDPGNSHENVTNAYHLRREETDWFDKPRDGRAENGQGMERRQGKFHYPF 3600

  Fly   839 PLA--------TGGSVSGAGTGAAI-------GAGGPCGAIVEKVKRGSVADLEGRIRPGDEILE 888
            |.|        ...||||.|.|..:       |:.|..||.|.||..|..|:..|:|..|.::||
Zfish  3601 PHARIKLLRDPKDRSVSGNGLGIRVVGGKEVPGSNGDIGAYVAKVLPGGAAEQTGKIVEGMQVLE 3665

  Fly   889 WNGRGLHNKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPAR 953
            ||...|..|:.:||..::...  ..:.||.:...|.....|..|
Zfish  3666 WNNISLSGKTYEEVQGLVGHQ--VGEAELCIRLDINMLSDSDSS--------------------- 3707

  Fly   954 RSSANFPHSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSPDIHTSVSGPG 1018
                   |..|...:.|                         |:|      |.||.:     .|.
Zfish  3708 -------HLDLHDQVKG-------------------------DRP------PRSPGV-----DPK 3729

  Fly  1019 SVSGSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAP 1083
            .::.. |::   |.|.|  .||                ||.|::..|         ||||..||
Zfish  3730 QLAAE-LQK---VSQQQ--VPS----------------SSASALDKP---------SASAGSSA- 3762

  Fly  1084 GGLHGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPI 1148
                                      :|.|.| .|.|:...:.|.       .:..||.||..|:
Zfish  3763 --------------------------VPSPGQ-PGSPSVSKKRHS-------KNSEGTKTQSHPV 3793

  Fly  1149 EGRLQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDR---------SHKSKRRT 1204
            .|.:||::.||:....|||.::.|..|:.|.:....:|:.||:|||.|         |.::|||:
Zfish  3794 SGEIQLQINYDKQLGNLIVHVLQARNLAPRDNNGYSDPFVKVYLLPGRGQVMVVQNASAENKRRS 3858

  Fly  1205 KTVGTTCEPRWGQTFVYSGLRRCDLNGRLLEVTLWDYVRYGANDFIGEVVIDLAHHI-LDDEAEW 1268
            |.|..|..|.|.||.:|..:....|..:.|||::|||.:..||||:|||:|||::.. ||:...|
Zfish  3859 KHVQKTLNPEWNQTVIYKNIHLEQLRKKTLEVSVWDYDKSSANDFLGEVLIDLSNTAQLDNVPRW 3923

  Fly  1269 YQLQPHQDTSYLLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGS 1333
            ..|:...:..:..|.....       ...|...|                     ||..    ||
Zfish  3924 LPLKEQSEGEHHRRSHSGQ-------GRQHSPKP---------------------PGGH----GS 3956

  Fly  1334 SASPPPLLELDLNERRSRRDMSPQG---RKRVAGMV---ARDYRTVSGIGQSYHNQASATGYYRR 1392
            ..||.       ....|:.| ||:.   :.|..|:.   |:|.: |..|.:|:.:.:|:......
Zfish  3957 QHSPK-------TSGHSKED-SPKSSVIKSRSHGIFPDPAKDTQ-VPTIEKSHSSPSSSKPSLSE 4012

  Fly  1393 GGGNGVGSAIGPGGMSLSQRSHSAAPSDGYHSSGVGGAASGGPAYGY--RSTSPRRGSLSPPDDR 1455
            |.....|   ||       |:|..:.:...|   :..||:...|.|.  |....:.|.|.|...|
Zfish  4013 GQARPHG---GP-------RAHGKSGTTRAH---LDDAAAMAEAAGQQPRLQPTQNGGLDPRHHR 4064

  Fly  1456 YIDYPVLPVHGSSPNAPSVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSR 1520
            :....||.:..:...:|: ::.|.|.......|..::|.|       |.|:.:..:....|.|:.
Zfish  4065 HSVVGVLTIQRAPSESPA-HEVPDGRHLTLRKALSEERPQ-------PDGASRSHRSGDAPVTAA 4121

  Fly  1521 S----------AMLRDRLGQD-FDERLASGGRFGR-----HRTRQPHHQATYRSTGMG 1562
            |          ::|.:..|.: .|..:....|||:     ...:..|..|..::..||
Zfish  4122 SLDSGLSGSAFSLLDEEGGTNAVDSAIFQVPRFGKIPNGTEAVKSAHGDAEGKTQVMG 4179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rim	NP_001247163.1	PHD_SF	8..126	CDD:304600	31/174 (18%)
		PDZ_signaling	817..919	CDD:238492	36/123 (29%)
		C2A_RIM1alpha	1148..1272	CDD:175997	50/133 (38%)
		C2B_RIM1alpha	2633..2775	CDD:175994
pcloa	XP_009298508.1	zf-piccolo	355..413	CDD:283393
		zf-piccolo	713..770	CDD:283393
		Zein-binding	<2492..2569	CDD:282441	5/28 (18%)
		PDZ_signaling	3604..3695	CDD:238492	28/92 (30%)
		C2A_RIM1alpha	3793..3927	CDD:175997	50/133 (38%)
		C2	4175..4312	CDD:301316	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910