DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rim and rims2

DIOPT Version :9

Sequence 1:NP_001247163.1 Gene:Rim / 42150 FlyBaseID:FBgn0053547 Length:2798 Species:Drosophila melanogaster
Sequence 2:XP_031759407.1 Gene:rims2 / 100125032 XenbaseID:XB-GENE-980175 Length:1762 Species:Xenopus tropicalis


Alignment Length:2911 Identity:647/2911 - (22%)
Similarity:939/2911 - (32%) Gaps:1294/2911 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDEMPDLSHLTPHERMQIENVLMRQKQEEEKQNEIMRRKQDE----------------------- 42
            |.|||||||||..||..|..|:.|||:||||:..:::.|:::                       
 Frog    21 MPEMPDLSHLTEDERKIIMAVMERQKKEEEKEQSVLKVKEEQKAQPAQWFPFSGITELVNNVLQP 85

  Fly    43 ----------VVTLEMQIRQRSEQQKKAGVELD---------ATCHICLKTKFADGVGHICHYCN 88
                      .:.|..|.....||.||.|.|..         .||.||.|||||||.||.|.||.
 Frog    86 QPKEQNEKEPEIKLHQQFEMYKEQVKKMGEEAQQQQEQKGEAPTCGICHKTKFADGCGHDCSYCQ 150

  Fly    89 IRCCARCGGKVTLRSNK----VIWVCILCRKKQELLSKTGQWINKTAAQQDGFIRRIEPDGSSDI 149
            .:.||||||:|:|||||    |:|||.||||:||:|:|:|.|...:              |||  
 Frog   151 TKFCARCGGRVSLRSNKEDKVVMWVCNLCRKQQEILTKSGAWFYSS--------------GSS-- 199

  Fly   150 SQHPIVDPHDTTDKRPKLERTRSAAEKENLPMQRAGSMLRRQYSQQEQPTNRRLS-ASDSG---- 209
                       |..:|. |.:::..:.|..|.::...:  ::.||.:.|:...|: |||..    
 Frog   200 -----------TPLKPG-EESQAGYQTEEAPQEKKAKL--QEQSQYQGPSGDLLTPASDKNRPQG 250

  Fly   210 ---MDPVMSPGQQMQHHQQQQRARMQPMNPQQAQQGYGMQQQQQPRSGGAYPDDDPRYYQGELDG 271
               .|.:.: |.:::|          |:....|.     .:::.|    :.|.|..|.|....| 
 Frog   251 IVRQDSIKN-GSELKH----------PIPGDLAS-----DRKRSP----SIPRDQNRRYDTRDD- 294

  Fly   272 LMRQHPHLAHPSQVQPQHTPQSHSQQQQSQHQQQHLMPQQHRPSPQQHSQQQQQQQQHSQQFAAR 336
             :.:|...|......|: :|..:|.::..:..|.:..|        :|...::.::: |.:::..
 Frog   295 -IGEHSQHATSDSAMPR-SPSDYSDRRLQRGSQLYDEP--------EHGDYRRSRRR-SNEYSVD 348

  Fly   337 QQ--QHQQQQHQQQVQQSYHAQIHQQPQ-----QHPHPHSQQQQHHQQM----QHQHGQSVPQMG 390
            ::  |.:::..:|:.::.|.|:....|.     ..|.|:.:|.:.|.::    |.:|........
 Frog   349 EEDIQDREEYERQRREEEYQARYRSDPNLARYPVKPQPYEEQMRIHAEVSRARQRRHSDVSLAQT 413

  Fly   391 GYQKPPPLTRNLTISGGHAMDSSAYSQQQQQQQRRALAGSQYASQQQRSFSSSEEEFQHQLLAAQ 455
            .:::....|..:          ...|:|:...:|||      |.:.|||:|              
 Frog   414 EFEESRMSTLRM----------ERPSRQRSASERRA------AMESQRSYS-------------- 448

  Fly   456 GAVTVTAGSDYDG---GRLQVRTSLDPWRQQRSL-NERDLLSSGGGGGGGVGGADFRHLSHATQR 516
                :....|..|   ||.:......|..::..: |:|                           
 Frog   449 ----IERTRDVQGPGPGRQRTSNHSPPTPRRSPIPNDR--------------------------- 482

  Fly   517 LYASADQRDRYELQLQHR-ERLEQYPLTRTARLDVQQRN-SLNRSNHERQFSGGGAGVGPGGAGG 579
                .|.|....|:.||. :.......|:..:::...|| ||:....|                 
 Frog   483 ----PDMRRTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSE----------------- 526

  Fly   580 GGAAGAYRRAPPL--AAAGGGGSSSSSTTSSSYYPQSKPQIVIGPGSGYDRGSGSMASMASAAAA 642
                 :.|..||.  ....||.....|.:||.....|.|:..          |.....:.|.:.:
 Frog   527 -----SVRPPPPKPHKTKKGGKMRQVSLSSSEEELASTPEYT----------SCDDVEIESESVS 576

  Fly   643 TAADAQGQAARNSQRGGLLGATRGGGGSSSVSSTEAAYWDEPATSSSSSAAQDSRRFTERRIKKT 707
            ...|        ||||                         ...:|..:...||...:||: ||.
 Frog   577 EKGD--------SQRG-------------------------KRKTSEQAVLSDSNILSERQ-KKM 607

  Fly   708 VRFDAHDEEASILASSSLPPVTAILPSTAVDVGAATILSSGKSLDAVGVGGADWSRWEAERQGSQ 772
            |.|..|..|..:                                        :||          
 Frog   608 VCFGGHSLEEDL----------------------------------------EWS---------- 622

  Fly   773 DSATKDSGIDTSSTFTSSEDSNRGDGPKNPVNWQTSADNTRLIGHMILRKYY-------DGEDIL 830
            :...||||:||.|:.|.:|:.:..:  |:||.||.|.|..||||.::|.|..       |...:|
 Frog   623 EPQIKDSGVDTCSSTTLNEEHSHSE--KHPVTWQPSKDGDRLIGRILLNKRLKDGSVPRDSGAML 685

  Fly   831 GLKVNGGQPLATGGSVSGAGTGAAIGAGGPCGAIVEKVKRGSVADLEGRIRPGDEILEWNGRGLH 895
            ||||.||:...:|..               | |.:.|||:||:||..|.:|||||:|||:||.|.
 Frog   686 GLKVVGGKMTESGRL---------------C-AFITKVKKGSLADTVGHLRPGDEVLEWSGRILQ 734

  Fly   896 NKSADEVYDIIDESRLDAQVELIVSRPIGSGGGSGGSSANVSPISGASGGSANSVPARRSSANFP 960
            ..:.:|||:||.||:.:|||||:||||||                        .:|....|.   
 Frog   735 GATFEEVYNIILESKPEAQVELLVSRPIG------------------------DIPRIPDST--- 772

  Fly   961 HSGLASSMAGSAVVSSGGRYLQRKAPAVEAIEIHRDKPSVLITSPGSP----DIHTSVSGPGSVS 1021
            |:.|.||.:.         :..:|          .|:||:.:|||.||    |:...:|  |.:|
 Frog   773 HAQLESSSSS---------FESQK----------MDRPSISVTSPMSPGMLRDVPQFLS--GQLS 816

  Fly  1022 GSGLRQRGGVGQTQRLGPSHSTHSHSSSGSGSGSGSSTSSVHAPASAHGPVHASASASGSAPGGL 1086
            ...|.:|                                                          
 Frog   817 SQSLNRR---------------------------------------------------------- 823

  Fly  1087 HGTTTAGHHHHPHPHHYHPHQHPLPHPHQHQGPPAAHLQGHGVGGGIGMGSGSGTTTQPIPIEGR 1151
                ||                                                      |...|
 Frog   824 ----TA------------------------------------------------------PFVPR 830

  Fly  1152 LQLKLGYDQNTLQLIVTLVCATGLSLRQSGAGRNPYAKVFLLPDRSHKSKRRTKTVGTTCEPRWG 1216
            :|:||.||:...|||||::.|..|..|:.|..||||.|::.|||||.|:|||||||..|.||:|.
 Frog   831 VQIKLWYDKVGHQLIVTILGAKDLPSREDGRPRNPYVKIYFLPDRSDKNKRRTKTVKKTVEPKWN 895

  Fly  1217 QTFVYSGLRRCDLNGRLLEVTLWDY--VRYGANDFIGEVVIDLAHHILDDEAEWYQLQPHQDTSY 1279
            |||:||.:.|.:...|:||:||||.  ||...::|:||::|:|...:||||..||:||.|     
 Frog   896 QTFIYSPVHRREFRERMLEITLWDQARVREEESEFLGEILIELETALLDDEPHWYKLQTH----- 955

  Fly  1280 LLRDEGSDVDGLILTPTDHLSPPSTMSRLSDSDTTSDCDIDGMTPGASISSMGSSASPPPLLELD 1344
                   ||..|   |..|.||  .|.|.         .:.|.:|...:.:.||.:         
 Frog   956 -------DVSSL---PLPHPSP--FMQRR---------QLHGESPTRRLQNKGSYS--------- 990

  Fly  1345 LNERRSRRDMSPQGRKRVAGMVARDYRTVSGIGQSYHNQASATGYYRRGGGNGVGS--AIGPGGM 1407
                      ...|.||::.....||....|:|        ....:|..|.:...|  ::....|
 Frog   991 ----------YNSGSKRISDSEVSDYDCDDGVG--------VVSDFRHNGRDLQSSTLSVPEQVM 1037

  Fly  1408 SLSQRSHSAAPSDGYHSSGVGGAASGGPAYGYRSTSPRRGSLSPPDDRYIDYPVLPVHGSSPNAP 1472
            |.:..|.:..|    |...:|..         ||.||   |:.||..|.::              
 Frog  1038 SSNHCSRTGPP----HVDSIGRT---------RSWSP---SVPPPQSRNLE-------------- 1072

  Fly  1473 SVYQGPGGVSSAAASASQQQRFQSRSATATPTGSPKKRQLPQVPQTSRSAMLRDRLGQDFDERLA 1537
               |||.|..|..|..:...|.:                                          
 Frog  1073 ---QGPRGTRSGPAHYNTMSRVE------------------------------------------ 1092

  Fly  1538 SGGRFGRHRTRQPHHQATYRSTGMGGWERHYTGLSDSDLHSMDARMRPRHSLSPDKDFMGEFGD- 1601
                  |||....|:                                     |||:|...|..| 
 Frog  1093 ------RHRVLDNHY-------------------------------------SPDRDRNCEAADR 1114

  Fly  1602 --------SDMESVVSVTSSAFSTQSERPRTSRGLSFPRNWRNLFGVRNSFLGGAGGEPITGLRL 1658
                    ::...|:..|||. |..:|||.::...|.|           |.:.|....|...|..
 Frog  1115 QPYQRSRSTEQRPVLERTSSR-SRSTERPDSNLMRSMP-----------SLMTGRSAPPSPALSR 1167

  Fly  1659 HHSEPGRANTIEVDDCDYLPVGGAQQLVLLEQLEQLQQLAALAAADSPPISAGIGIQPPHQVL-- 1721
            .|  |.|..:::..... .|:.|.:.       .||.||                  ||...|  
 Frog  1168 AH--PPRTGSVQTSPSG-TPLAGRRG-------RQLPQL------------------PPKGTLER 1204

  Fly  1722 -VTDANSGQLVEQFYVEPGTMAEEMMEPLDPHLHPHSVFYSPSPHLPPQPFDIDIDTIYPPRRSN 1785
             ||..:..:.|.      |::.:      |.||                           ||:..
 Frog  1205 KVTWEDQQRKVN------GSITD------DKHL---------------------------PRKKQ 1230

  Fly  1786 GLKPNVQATAAAYPLPLLPSFEQFKRITTPITNFFRSSSPAGVHPHAHDHTSTTPSSLVGYVRDH 1850
                                                       |....|..||.        |.:
 Frog  1231 -------------------------------------------HSEPEDMDSTR--------RRN 1244

  Fly  1851 QDKSCSHCQNGSQPVVLSTHHTLHLTAAGLAIGACQDPCCLADAHPHPQHQPMGYGEPPSSDPAM 1915
            .::..:..:||:                                                     
 Frog  1245 SEEKAAEQENGN----------------------------------------------------- 1256

  Fly  1916 CGECVDQHFLGGLTGPQLNLGVVPTYHVHTPTPNAHRRARGQMATPAPPPTQSVLRLSRQLSEDA 1980
                                                            |....|...:|||    
 Frog  1257 ------------------------------------------------PGAMDVEERTRQL---- 1269

  Fly  1981 LVAAVPISEAKAQPTSILKKPKLERRRLFHEGQSRSLDYDDLHTK-SWGRRRIRYEDEVMPSSGD 2044
                               |.|:.:.:  ..|.|.|....|.|.| ..||...|..|.:...|.|
 Frog  1270 -------------------KVKINKYK--QVGGSDSRLEKDYHPKYRTGRDPQRGSDNMSNKSSD 1313

  Fly  2045 YPYPHSNPYSSYSPTAAMSRRYGSETNIRQSYMGANVDANHPLSHSHFLVTDDKIVTITYDSDVG 2109
                     |..|..:|:||...:......|||....:.                          
 Frog  1314 ---------SDVSDVSAVSRTSSASRFSSTSYMSVQSER-------------------------- 1343

  Fly  2110 WTRRGVAPSLFRGAHRQRGLADPRNHMSLDLQRTSQQKLYGPAAPYLKRRRNLPHPPSAQNAHNF 2174
                                  ||.:|.:. :||.:                             
 Frog  1344 ----------------------PRGNMKIG-RRTRE----------------------------- 1356

  Fly  2175 SPMEPGSGMDGLNAAAAGMVEQGNGMGSGGAHNTTSTHNSNHHNSQASSVSVSQSHNQ--QLQQQ 2237
                               ||:......||.|                       |.:  .|:::
 Frog  1357 -------------------VEERIERAEGGQH-----------------------HKEIGFLEEE 1379

  Fly  2238 QQLQQQSVRQKGKEGTTAISGSMMASEQLTKSSSGSGGATSAAAAGHLVVGGTNANNASSSSFAN 2302
            :.::|:...:|..|....|...|.                           |.:..:....|..|
 Frog  1380 EDVRQEVDSEKETEVQHIIDNCMK---------------------------GPSKESVEEESQQN 1417

  Fly  2303 PQPPPPQQQQQLHGSPNNLNNNNKRAPSSTPQQNTNTINDANNLTLDATQQQSQQQQLQQPPNTC 2367
            .:.......::.|      |.|..|..|.            |:::..|::.||:|.         
 Frog  1418 EKDEESHDVEEAH------NENLPRRSSE------------NDISALASKMQSRQM--------- 1455

  Fly  2368 TNQNTNPTTTLTTTTTTSSNATNAATTTTANATNATTTATNPTTTTTNNTNEPNATTTTTTTNAN 2432
                                        .|:..|                       .|.:|:..
 Frog  1456 ----------------------------GASGKN-----------------------MTKSTSIG 1469

  Fly  2433 ADADADADADAPLDAIDWDAIDAMLDDDFSEYDKDKNGAEEAGGSKSAEGAGAEDKVDGSLSDTA 2497
            .|.                            |..:||                    |||.||||
 Frog  1470 GDM----------------------------YTLEKN--------------------DGSQSDTA 1486

  Fly  2498 NDRKKGGGVDQERSPKGGS-----GMGKKSNSTSQLSATGRKRRMGFGKKGKNSFTVHRSEEVLP 2557
            ......|| .:.||..|..     |:.:||.||||||.|    .:| |||.|:  |:.||.|.  
 Frog  1487 VGTVGAGG-KKRRSSIGAKMVAIVGLSRKSRSTSQLSQT----EVG-GKKLKS--TIQRSTET-- 1541

  Fly  2558 GDITRELRTGGGLGVSLGGAGGAAGGSGGAGGGGLSRGSSSEVDAIEQFFGDG------AGGERF 2616
                       ||.|.:              ...:||.:|.|..       ||      :.|...
 Frog  1542 -----------GLAVEM--------------RNWMSRQASREST-------DGSMNSYSSEGNLI 1574

  Fly  2617 SPSLR--NDGALNEFVDGLGPGQLVGRQVLGAPSLGDIQLSLCHQKGCLEVEVIRARGLQQKAQS 2679
            .|.:|  :|...::|:|||||.||||||.|..||:||||:.:..:||.|||||||||||..|..|
 Frog  1575 FPGVRLGSDSQFSDFLDGLGPAQLVGRQTLATPSMGDIQVGMADKKGQLEVEVIRARGLVVKPGS 1639

  Fly  2680 KMLPAPYVKVYLVSGKRCVDKMKTSSARRTLDPLYQQQLVFKQSYTGCILQITVWGDYGRIEKKV 2744
            |.||||||||||:....|:.|.||..||:||:|||||.|.|::|..|.:|||.|||||||::.|.
 Frog  1640 KTLPAPYVKVYLLENGVCIAKKKTKVARKTLEPLYQQVLAFEESPQGKVLQIIVWGDYGRMDHKS 1704

  Fly  2745 FMGVAQIMLDDLNLSNIVIGWYKLFGTTSLVSCPTNIGLGSRRSSIASLDS 2795
            |||||||:||:|:||::||||||||..:|||. ||...| :||:|.:||:|
 Frog  1705 FMGVAQILLDELDLSSMVIGWYKLFPPSSLVD-PTLAPL-TRRASQSSLES 1753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RimNP_001247163.1 PHD_SF 8..126 CDD:304600 65/163 (40%)
PDZ_signaling 817..919 CDD:238492 44/108 (41%)
C2A_RIM1alpha 1148..1272 CDD:175997 63/125 (50%)
C2B_RIM1alpha 2633..2775 CDD:175994 91/141 (65%)
rims2XP_031759407.1 FYVE_like_SF <146..194 CDD:333710 29/47 (62%)
PDZ_signaling 677..758 CDD:238492 42/96 (44%)
C2A_RIM1alpha 830..953 CDD:175997 63/122 (52%)
PHA03307 956..>1198 CDD:223039 77/440 (18%)
C2B_RIM1alpha 1593..1738 CDD:175994 93/145 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I4418
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 601 1.000 Inparanoid score I937
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D109268at2759
OrthoFinder 1 1.000 - - FOG0000817
OrthoInspector 1 1.000 - - otm47771
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2752
SonicParanoid 1 1.000 - - X2115
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.090

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