Protein Alignment MAP3K3 and mtk-1

DIOPT Version :9

• Sequence 1: NP_976226.1
• Gene: MAP3K3 / 4215
• HGNCID: 6855
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_001367356.1
• Gene: mtk-1 / 172246
• WormBaseID: WBGene00003472
• Length: 1420
• Species: Caenorhabditis elegans
• Alignment Length: 766
• Identity: 186/766 - (24%)
• Similarity: 298/766 - (38%)
• Gaps: 190/766 - (24%)

Human     7 LNSIMND----------LVALQMNRRHRMPGYE-----------------------TMKNKDTGH 38
            |||:..:          |:.:.:|..|...|||                       ||.:.:.|.
 Worm   698 LNSLTREVKERELRIFSLLRITLNDSHDAVGYELRSGVDRAQMFHEMVPDFCLIQLTMASDEQGD 762

Human    39 SNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFSRPVKYE----- 98
            .|....|.:....|....|         |..|.::           |..::|.|...|.:
 Worm   763 VNDDDDHVNLKIVLFVYRT---------SVDKAYV-----------ETCMLAISEGRKIDDGCIV 807

Human    99 ---DVEHK---------VTTVFGQPLDLHY--MNNELSILLKN---QDDLD-KAIDILDRSSSMK 145
               |.:||         |..|..:...:.|  :.:::.:.|.|   :.|:: |..:.|...|...
 Worm   808 IVPDKDHKLRKHWKGRVVKIVIDEETRICYRWLRDDIILCLANGSIRADMEHKYKNFLKCISPAC 872

Human   146 SLRILLLS--QDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSP 208
            |...|:.|  |.....|..||....|: ||.......:|.  .:|.|.:|:..|..|.
 Worm   873 SSNFLITSRIQQLTEESLLPHLDEERK-RIGILLEKTEIR--LEPKEEQSKEKSALSS------- 927

Human   209 PPGYVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSS--AENSLSGSCQSLD----RSA- 266
             .|:..|:...:|.|     |:.:   :.:......:|.|.:  .|.:|:.:.|.:.    :|.
 Worm   928 -LGFKLEKHFLVAFQ-----IHRD---VAKVVSDSFMDGLGNEMVEKALALTRQWMQYVEVKSTI 983

Human   267 --------DSPSF------RKSRMSRAQSFP-DNRQEYSDRETQLYDKGVKG----------GTY 306
                    .||.|      .:.|.|..:... |..||::|.......|.:|.          ||.
 Worm   984 PSPTLPMWASPGFTFLQYITEPRWSNPEIMTNDQFQEFNDLVKLFEAKVIKSSSNIGTPGNTGTP 1048

Human   307 PRRYHVSVHHKDYSDGRRTFPRIRRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPR-------- 363
            .:|...|...|..|.......|.|:                   ||..|.:|.|:.:
 Worm  1049 MQRNTRSTSSKTSSSSMENHKRTRK-------------------ENQMLKLQELEDKRNRIDYDN 1094

Human   364 ---GRLRSADS-ENALSVQERNVPTKSPSAPINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQV 424
               |::.:.|: .|.:...::.:.||   ||..|.....:..|:||.|:...|:|:.|.:|:|.:
 Worm  1095 LQIGKVITDDNRRNFVLATDKKITTK---APFQWALLDHIASGSFGSVHRAMDIDSHRVIAAKVM 1156

Human   425 QFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAY 489
            :...::.:      |:|.||.:.:.|.||.:|:|||...:  :..:.|||||...|::  :...:
 Worm  1157 RIQRENHK------AIESEINIFRQLIHENLVKYYGVQVE--DSDVIIFMEYCSQGTL--ERICH 1211

Human   490 GALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTG 554
            |.:...:.|:||..:|..:.||||:.|:|||||.|||..|....:||||||.|.||.........
 Worm  1212 GKMDLKMVRQYTNSLLRAVQYLHSHKIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGE 1276

Human   555 MRSVTGTPYWMSPEVIS-GE---------GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFK 609
            .::..|||.:|:||:.| ||         ||||..|:|:||.|||.|:|.|.|:.........|.
 Worm  1277 FQTTAGTPQFMAPEIYSYGEKDETTGSYSGYGRSVDIWALGATVVNMMTGKVPFEGQTRHQIAFA 1341

Human   610 IATQPTNPQLPSHISEHGRDFLRRIFVEA-----RQRPSAEELLTHHFAQL 655
            :..:...|..|. |::...| ::|.|...     ..||:|.|||...||.:
 Worm  1342 LCFRKQKPTYPD-IADKRPD-VKRFFDNCFEFLPNDRPTAAELLQTTFANV 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP3K3	NP_976226.1	PB1_Mekk2_3	76..154	CDD:99726	19/102 (19%)
		STKc_MEKK3_like	392..652	CDD:270795	92/274 (34%)
mtk-1	NP_001367356.1	PKc_like	1125..1388	CDD:419665	92/274 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55144at2759
OrthoFinder	1	1.000	-	-		FOG0001353
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920