Protein Alignment tinc and K09F5.6

DIOPT Version :9

• Sequence 1: NP_001262686.1
• Gene: tinc / 42148
• FlyBaseID: FBgn0261649
• Length: 1513
• Species: Drosophila melanogaster
• Sequence 2: NP_001362111.1
• Gene: K09F5.6 / 4363114
• WormBaseID: WBGene00044698
• Length: 919
• Species: Caenorhabditis elegans
• Alignment Length: 1350
• Identity: 229/1350 - (16%)
• Similarity: 381/1350 - (28%)
• Gaps: 565/1350 - (41%)

  Fly    75 LNSLWSIWYGVMLTLFQGYLAMHGAYRFLGCSLIPWKI--EPVAELNLQIVLSGVVFILLPVFFT 137
            ||:|.||||.::.||.|.||...|..|:...:.|.|..  .|...|.....:.....|...:|||
 Worm     9 LNNLSSIWYTILTTLLQSYLLYLGFERYRLYNEIKWPTGGYPYGYLMAYATIYLCCIIATFLFFT 73

  Fly   138 SAVFKVGNLANDGIKLATGARERRCTLSPHDGLEEESRGGTLRALWTHGGPTAAFVHIVIALCLL 202
            ..|||.||:|.|..:|| ...||...:|.:...|:.......:.||.|..|....:|::||:..|
 Worm    74 CGVFKSGNIAGDNERLA-DREERVLEVSRNQNGEKSGCVHGAKVLWQHLPPLPQQLHVIIAVAQL 137

  Fly   203 LPRLLLEARIIENGLLPKEQIWATELDFVVINRRNLMAMSVVGATPFPRHHQPSNQQQSHHQHGR 267
            :.:.|:.:::..:|.:.......|||||:....|.|       ||..|
 Worm   138 IAQQLMFSQLFRHGFVNSGDFLNTELDFLYQRSRQL-------ATNLP----------------- 178

  Fly   268 LNLTANSLEQDEEDYFNDTMFTAIRGVPAGGNNNLFDLRPDRMANGRKAAKTTATTRTTTTANKL 332
                                                                             
 Worm   179 ----------------------------------------------------------------- 178

  Fly   333 DAGKGQYFEVPDLINQDIDEEERQELEEAIRGEEDDGDEGVGVGEEGTVIMPDFDELAPRTAVGT 397
                                                      :||
 Worm   179 ------------------------------------------IGE-------------------- 181

  Fly   398 STTTAKASSDADKLNVENWQQLGTLGKADASSSSSSTTSTTTTTTTSTTTTAATTTSTRGTSTTT 462
                                                                             
 Worm   182 ----------------------------------------------------------------- 181

  Fly   463 TTTTIKPMEITTSRQSAHHHHGKSRKHHKHHNKQRQQQPPRRHHVASHEQAILESFPEEETTTRD 527
              |.::...||...                                      |...|
 Worm   182 --TRLQGFRITADE--------------------------------------LAGLP-------- 198

  Fly   528 SSIHRVRPEVLPELPIPSTPVSASNSKIIAIKAKNQKRRISKRAAGVEIEPEYLLGDANINSSEF 592
                 |.|.:||.|
 Worm   199 -----VSPNLLPVL--------------------------------------------------- 207

  Fly   593 VAKSNEEEPEESEDFELEDGDFQAVPALTPAPPAEPNGPKSGQDYVRLDGFAGMLQLFFGIDKPI 657
                                                                 |....|||  |:
 Worm   208 -----------------------------------------------------MHMKLFGI--PL 217

  Fly   658 DVAIFSQPPSAEFVNLLCALLVWSVRYPAVFWNTSKAFACVFSLQMVVAALDIILGYVGISNLYK 722
                       |.|||..||:.:::.||||||..||.|:.:|||.:|:.|..:|.||:..|.|::
 Worm   218 -----------EMVNLFIALVAFAIAYPAVFWRVSKPFSVIFSLHLVIYAAQVIWGYLSFSILFR 271

  Fly   723 LQ------IYAEAM-----PVHQPGL-ILNAVVTLALYLLSTALVLASSMVMYLYGHGRLATRM- 774
            :|      :.|..:     |:...|. |.:..|.|..:::...:...:.|.||.||:.:|...:
 Worm   272 IQETNIHSVRAVGLGQYLGPIKPLGFHIYHPYVILGSFVVRLVMTTLAPMAMYSYGYNKLYANVL 336

  Fly   775 --------------------RDRSIITLKTHQTWI--YFAHCASLCFVLALAVVKAPLLNDLSAT 817
                                |.||...:..::...  |..|..::..::.:|....|.:..|...
 Worm   337 NVQHRNAARTSQGQAEYGDYRRRSYTRVDGNKLCCDGYLPHMDAIALLVIVAGAIGPTIYALLIL 401

  Fly   818 YKNNLHCPTFLAALVGVTHLLLWIVIWLCLTIKRRWHFKLP-PLDSTYGGLLGKSSAQPLLMSSG 881
            |::..........::.|.::..||::||.:|:||.|.|.:. .:...||  |.|.      |:.|
 Worm   402 YQHEQKALILTCIIIDVVYMFSWILMWLGMTLKRDWDFNVTHKVHQFYG--LNKG------MAIG 458

  Fly   882 QRTGSNSSSSGCNS-------TSTTVNGGDSKPDMMSTATSTELGMGMGMGIGGGINGGMGGTGM 939
            ...|:.:.|...||       |....:...:|..::....|.:..|
 Worm   459 PIRGNENPSQLKNSILVVHRDTMFVTDDQTAKQSLLRAIHSGKFEM------------------- 504

  Fly   940 GLAAQEDIYWPKLTPSSPKLKVTFNEVTSTSDD-----VLLIG-DQEQTDGKRHTSRGASVCFAS 998
             ::..:|:||.:...|.........||....:.     :|.:| |..|.....|::.|.::..|.
 Worm   505 -ISPPDDVYWRQGQQSPATRAKILTEVDGVKNSPEMSRLLRMGTDDTQQTMSYHSNGGRNITQAQ 568

  Fly   999 ATGE--VDDGEYATLRAATAGAVVG-----ITMGSMKRGLS-NTSVGVSLLHLSEYDELPPPPPA 1055
            .|..  :..|..:....:..|.:..     ..||:::||.| .|....:::|            .
 Worm   569 MTNSQILQRGNSSPPGPSQFGTIQRNQQQYSQMGTLQRGQSGGTLQRGAMIH------------D 621

  Fly  1056 NLHHQQQQQQQQQQRQAHSFAHGHPHDYANLSGLGGISDDNISEEGKLLACVRDDSITYASTSDL 1120
            |:.:|....|::.::|.|.              ||...|...:..|::      || ||.|.:.:
 Worm   622 NVWNQYSAIQKKDEQQQHM--------------LGQRRDSGEAAYGRV------DS-TYGSYARI 665

  Fly  1121 EPPQPSAQAPPPPPPLPIKGAPVPQPPAVMPHSAGIYGRAPQAMPEMMQLSPEHHHNPLQHSLQH 1185
             |.....|..|....:.:.|                ||...|...:..:::|..|..  |.||..
 Worm   666 -PNVSRIQVTPQGSQIRVNG----------------YGGLQQNTLQRREVTPTQHSQ--QPSLSS 711

  Fly  1186 PQHHPLQQQQQ--KQQTPQHPLQQQGNPHQHLVSPLAPVTVAVHTNE-------AHIASSSTPRC 1241
            .:..||...:.  ....||..:.::.:|:|.....|:    :...|:       :.|.|.:..:.
 Worm   712 IRQSPLLSDRSGINVPPPQPLVSREQSPYQRSAIKLS----SFSENKGSGIYGTSGIGSGNNVQW 772

  Fly  1242 --LRRADSGVPNEAL------TPRSDTTSTTESTNTTSPPERAPSESSSGVHSGEERELEVIIRP 1298
              .:||..|.|.:.|      |...:.:|.|.:||::...|:..:.:|:....|
 Worm   773 GGAQRAAPGQPGQLLWNPPGATNGHNKSSLTSTTNSSQNDEQCFTPTSTLTSHG----------- 826

  Fly  1299 RANSKPPPRPPQ--PPIQEEPYGRCTNMRMSSFNADPAATSSAVINSATL 1346
             :|..|.|..||  .||    |.|......:|.|....|:..:.....||
 Worm   827 -SNYTPTPGSPQGSNPI----YSRINGASSTSSNLYGVASKESQYADRTL 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tinc	NP_001262686.1	None
K09F5.6	NP_001362111.1	Med15	<552..>856	CDD:312941	72/375 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	165	1.000	Domainoid score	I2366
eggNOG	1	0.900	-	-		E1_28NE0
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	166	1.000	Inparanoid score	I2795
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016585
OrthoInspector	1	1.000	-	-		oto19446
orthoMCL	1	0.900	-	-		OOG6_124472
Panther	1	1.100	-	-	LDO	PTHR21579
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16911
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980