DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg1 and ALG1

DIOPT Version :9

Sequence 1:	NP_650662.1	Gene:	Alg1 / 42146	FlyBaseID:	FBgn0038552	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_061982.3	Gene:	ALG1 / 56052	HGNCID:	18294	Length:	464	Species:	Homo sapiens

Alignment Length:	440	Identity:	204/440 - (46%)
Similarity:	282/440 - (64%)	Gaps:	17/440 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RNACVIVLGDIGRSPRMQYHAQSLLEENYHVDMIGYLETRPLEELTQHPRCRIHELTAVPVTNLT 73
            |:...:||||:||||||||||.||....:.|.::|:..::|.:||.|:.|.:|..||.:....:.
Human    33 RHVVAVVLGDVGRSPRMQYHALSLAMHGFSVTLLGFCNSKPHDELLQNNRIQIVGLTELQSLAVG 97

  Fly    74 PKL-RLLFKAFWQTLSLLMALISIGRPSFLLVQNPPGIPTLIVCYLYCAVTRTKLAIDWHNYTYT 137
            |:: :...|...|.:.||..|:.....:::.:|||||:|::.||:....:..:||.||||||.|:
Human    98 PRVFQYGVKVVLQAMYLLWKLMWREPGAYIFLQNPPGLPSIAVCWFVGCLCGSKLVIDWHNYGYS 162

  Fly   138 VLALGMSKGEQSPLIRLVRRLERYFGSKAHTHFCVTRAMQEDLQQNWGIGPVKVLYDRAPAQFH- 201
            :  :|:..|...||:.|.:..|::||..:|.:.|||.||:|||..||.|..|.| ||: ||.|.
Human   163 I--MGLVHGPNHPLVLLAKWYEKFFGRLSHLNLCVTNAMREDLADNWHIRAVTV-YDK-PASFFK 223

  Fly   202 --PIDLTHKHELYLKLAKDYPQFQAKDAEQSDVLEATALTQKLA-SGVVQYRPQRQAVLVSSTSW 263
              |:||  :|.|::||...:..|:|:...:..|.|.:|.|::.| ||:|....:|.|:|||||||
Human   224 ETPLDL--QHRLFMKLGSMHSPFRARSEPEDPVTERSAFTERDAGSGLVTRLRERPALLVSSTSW 286

  Fly   264 TPDEDFGILLKALQAYEE-TAQAEPLVYPSLLCIITGKGPQKEHYVAEIEKLQWQKVSVITPWLE 327
            |.||||.|||.||:.:|: |.....|  |||:|:||||||.:|:|...|.:..:|.:.|.|||||
Human   287 TEDEDFSILLAALEKFEQLTLDGHNL--PSLVCVITGKGPLREYYSRLIHQKHFQHIQVCTPWLE 349

  Fly   328 IEDYPTVLASADLGVCLHWSTSGLDLPMKVVDMFGSGLPVCAYDFKCLDELVKHGENGFVFGDHV 392
            .||||.:|.|||||||||.|:||||||||||||||..|||||.:||||.|||||.|||.||.|..
Human   350 AEDYPLLLGSADLGVCLHTSSSGLDLPMKVVDMFGCCLPVCAVNFKCLHELVKHEENGLVFEDSE 414

  Fly   393 QLAEQLRIWFENFPKNPSILETRAGFQRKIQEFQELRWRESWRLIAAPVL 442
            :||.||::.|.|||.....|..   |::.::|.|:|||.|||.....|::
Human   415 ELAAQLQMLFSNFPDPAGKLNQ---FRKNLRESQQLRWDESWVQTVLPLV 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg1	NP_650662.1	GT1_ALG1_like	6..442	CDD:99986	204/438 (47%)
Alg1	NP_650662.1	PLN02275	7..402	CDD:215155	189/398 (47%)
ALG1	NP_061982.3	PLN02275	27..424	CDD:215155	189/398 (47%)
		GT1_ALG1_like	30..461	CDD:99986	204/438 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	243..262		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147356
Domainoid	1	1.000	157	1.000	Domainoid score	I4146
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5387
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2140
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54337
OrthoDB	1	1.010	-	-		D330469at33208
OrthoFinder	1	1.000	-	-		FOG0003761
OrthoInspector	1	1.000	-	-		oto90694
orthoMCL	1	0.900	-	-		OOG6_102371
Panther	1	1.100	-	-	LDO	PTHR13036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3692
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770