DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alg1 and algn-1

DIOPT Version :9

Sequence 1:	NP_650662.1	Gene:	Alg1 / 42146	FlyBaseID:	FBgn0038552	Length:	446	Species:	Drosophila melanogaster
Sequence 2:	NP_498420.2	Gene:	algn-1 / 175920	WormBaseID:	WBGene00020820	Length:	491	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	186/447 - (41%)
Similarity:	262/447 - (58%)	Gaps:	31/447 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PKKRN-ACVIVLGDIGRSPRMQYHAQSLLEENYHVDMIGYLETRPLEELTQHPRCRIHELTAVP- 68
            |.:|: |.|:||||:||||||..||:.|.:|.:.|.:||:.::.|.|::..|||.:|..:...|
Worm     9 PDERSEAAVVVLGDVGRSPRMCNHAKMLADEGFDVKLIGFFDSIPGEQIMNHPRIKIVGIPPPPD 73

  Fly    69 -VTNLTPKLRLLFKAFWQTLSLLMAL---ISIGRPSFLLVQNPPGIPTLIVCYLYCAVTRTKLAI 129
             :.:|...::|..|.||..::|.:||   .|......:|:||||.:||:|||:::......|.:|
Worm    74 FMDSLPAFVQLPLKLFWNFITLFLALAFQTSAFNLRIILMQNPPALPTMIVCFMFSIFKFAKFSI 138

  Fly   130 DWHNYTYTVL----------ALGM-SKGEQSPLIRLVRRLERYFGSKAHTHFCVTRAMQEDLQQN 183
            |||||.|::|          ..|. .|.:::.::|.|..||...|..:..:.|||.||:.||...
Worm   139 DWHNYMYSILQNKYQLTDDQVFGNDKKTKKAQIVRCVGFLEGLCGKLSDYNLCVTNAMRRDLMDR 203

  Fly   184 WGIGPVKVLYDRAPA-QFHPIDLTHKHELYLKLAKDYPQFQAKDAEQSDVLEATALTQKLASGVV 247
            ||| .....|||.|. :|....:...|:|||:|::.....|.||.      ::|.||.|.::|||
Worm   204 WGI-RASTFYDRPPTWKFRDTTIQEIHDLYLRLSQKERILQGKDE------DSTILTHKSSNGVV 261

  Fly   248 QYRPQRQAVLVSSTSWTPDEDFGILLKALQAYEETAQAEPLVYPSLLCIITGKGPQKEHYVAEIE 312
            |....|..|.:|||||||||.|.|||.||.||::|     :..|.:|.|||||||.|..|:.||.
Worm   262 QLLTTRPIVFLSSTSWTPDERFEILLDALVAYDKT-----IGLPRVLMIITGKGPLKAKYLQEIH 321

  Fly   313 KLQWQKVSVITPWLEIEDYPTVLASADLGVCLHWSTSGLDLPMKVVDMFGSGLPVCAYDFKCLDE 377
            :...:.|.|:|||||.||||.:|||||||:.||.||||||||||||||||:.:|..|..|||:||
Worm   322 EKNLKNVDVLTPWLEAEDYPKILASADLGISLHTSTSGLDLPMKVVDMFGAKVPALALKFKCIDE 386

  Fly   378 LVKHGENGFVFGDHVQLAEQLRIWFENFPKN-PSILETRAGFQRKIQEFQELRWRES 433
            ||:...||::|.|..||:.|:......||.| ..::..:...|.:..:..|:.|:.|
Worm   387 LVEEKTNGYLFDDSEQLSRQIIELSRGFPNNCNELIRLKKNTQEQKFDSWEVMWKRS 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alg1	NP_650662.1	GT1_ALG1_like	6..442	CDD:99986	186/447 (42%)
Alg1	NP_650662.1	PLN02275	7..402	CDD:215155	178/412 (43%)
algn-1	NP_498420.2	GT1_ALG1_like	11..447	CDD:99986	185/445 (42%)
algn-1	NP_498420.2	PLN02275	12..410	CDD:215155	178/409 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159479
Domainoid	1	1.000	144	1.000	Domainoid score	I2872
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5387
Inparanoid	1	1.050	322	1.000	Inparanoid score	I1486
Isobase	1	0.950	-	0	Normalized mean entropy	S1491
OMA	1	1.010	-	-		QHG54337
OrthoDB	1	1.010	-	-		D330469at33208
OrthoFinder	1	1.000	-	-		FOG0003761
OrthoInspector	1	1.000	-	-		oto19461
orthoMCL	1	0.900	-	-		OOG6_102371
Panther	1	1.100	-	-	LDO	PTHR13036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R40
SonicParanoid	1	1.000	-	-		X3692
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790