DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Odj and E4f1

DIOPT Version :9

Sequence 1:	NP_650661.1	Gene:	Odj / 42145	FlyBaseID:	FBgn0038551	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001288713.1	Gene:	E4f1 / 13560	MGIID:	109530	Length:	783	Species:	Mus musculus

Alignment Length:	514	Identity:	105/514 - (20%)
Similarity:	175/514 - (34%)	Gaps:	158/514 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ECRICGERIFTP-----HPKNIFEKRNHRIRMAIEQITGLEIVLENMLPQHICACCLLDLTQAVA 63
            ||::||....|.     |.:...::|.::                       ||.|.....::.|
Mouse   222 ECKLCGASFRTKGSLIRHHRRHTDERPYK-----------------------CAKCGKSFRESGA 263

  Fly    64 FRQR------CLETHANLHQRISSKAGVASKGSPEVSPVLSDPLLKREVLDDTVDTEDDKELLDD 122
            ..:.      |.|   .:...||....|..:..|..|...:...:...|..|.::|.....|:.|
Mouse   264 LTRHLKSLTPCTE---KIRFSISKDTAVGKEEVPAGSSASTVGTVTSSVAGDPMETSPVIHLVTD 325

  Fly   123 DKDLMDDDKDFLEDEKPI------LRYPPAKKIRIEDQNF------------------------- 156
            .|..:..:......|.|:      ...|.::::....:|.
Mouse   326 AKGTVIHEVHVQMQELPLGMKALTPESPDSEELPCSSENSRENLLHQAMQNSGIVLERVAGEESA 390

  Fly   157 -----PNRQSPR-----------VRVKRLRVPVVEKADSPP---PPP----------------RE 186
                 |:..||:           ::|:::...|..:|.:.|   |.|                |.
Mouse   391 LEPAPPSGSSPQCLGDGSPELPLLKVEQIETQVASEAATVPRTHPCPQCSETFPTAATLEAHKRG 455

  Fly   187 HVRKPRKRRPKPKVDRSIKRYVCDQCGWSFNDHSNMKDHKLRH-FEEKFSCDECGRKFYTMPLLR 250
            |:      .|:|        :.|.|||.:|.....:|.|:..| .|.:|.|.:||:.:.|:..:|
Mouse   456 HI------APRP--------FTCTQCGKAFPKAYLLKKHQEVHVHERRFRCGDCGKLYKTIAHVR 506

  Fly   251 LHIRVHHKGEKPYVCKFCGMGFANSPSRCRHERQMHANELVHPCKICGKRFNSEKGRL-KHEEGH 314
            .|.|| |..|:|:.|..||..:....::..|.| .|..|..|.|:.|.:.|. |||.| :|...|
Mouse   507 GHRRV-HSDERPFPCPQCGKRYKTKNAQQVHFR-THLEEKPHVCQFCSRGFR-EKGSLVRHVRHH 568

  Fly   315 KSDQPDVHICLTCNKEFKEAQFLHRHYSTK---------------YHRKRVNLLVNGPKE---EF 361
            ..::|  ..|..|.:.|.|...|:||..||               .......:|...|..   ||
Mouse   569 TGEKP--FKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEESPSAAATVLAEDPHTVLVEF 631

  Fly   362 QSEVDPAEFPGYMEEGQAE----------MEDNQAELD----VMLDNIDEEQYEDHEVL 406
            .|.|  |:...|:.|..|:          :|..|.|:|    .::..|..:....|:::
Mouse   632 SSVV--ADTQEYIIEATADDTETSEATEIIEGTQTEVDSHIMKVVQQIVHQAGAGHQII 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Odj	NP_650661.1	zf-AD	5..77	CDD:214871	12/82 (15%)
		COG5048	<202..343	CDD:227381	46/142 (32%)
		C2H2 Zn finger	209..229	CDD:275368	7/19 (37%)
		C2H2 Zn finger	236..256	CDD:275368	7/19 (37%)
		zf-H2C2_2	249..274	CDD:290200	10/24 (42%)
		C2H2 Zn finger	265..283	CDD:275368	4/17 (24%)
		C2H2 Zn finger	298..314	CDD:275368	6/16 (38%)
		zf-C2H2_jaz	322..347	CDD:288983	9/39 (23%)
		C2H2 Zn finger	324..343	CDD:275368	7/18 (39%)
E4f1	NP_001288713.1	Required for ubiquitin ligase activity. /evidence=ECO:0000250	40..84
		Mediates dimerization, DNA-binding, transcription repression of CCNA2 and interaction with HMGA2. /evidence=ECO:0000250	185..264		10/64 (16%)
		COG5048	193..594	CDD:227381	87/416 (21%)
		C2H2 Zn finger	195..215	CDD:275368
		zf-C2H2	221..243	CDD:278523	6/20 (30%)
		C2H2 Zn finger	223..243	CDD:275368	5/19 (26%)
		zf-H2C2_2	235..258	CDD:290200	5/45 (11%)
		C2H2 Zn finger	251..269	CDD:275368	4/17 (24%)
		Mediates interaction with CDKN2A. /evidence=ECO:0000250	368..565		49/213 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..407		3/20 (15%)
		Interaction with BMI1. /evidence=ECO:0000250	434..598		54/182 (30%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		zf-C2H2	462..484	CDD:278523	7/21 (33%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	8/20 (40%)
		zf-H2C2_2	504..529	CDD:290200	10/25 (40%)
		Mediates interaction with TP53. /evidence=ECO:0000250	520..579		19/62 (31%)
		C2H2 Zn finger	520..540	CDD:275368	5/20 (25%)
		zf-H2C2_2	534..555	CDD:290200	7/21 (33%)
		C2H2 Zn finger	548..568	CDD:275368	8/20 (40%)
		zf-H2C2_2	560..584	CDD:290200	6/25 (24%)
		Mediates interaction with RASSF1. /evidence=ECO:0000250	574..596		7/21 (33%)
		C2H2 Zn finger	576..595	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100