DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17801 and ZNF195

DIOPT Version :9

Sequence 1:NP_650660.2 Gene:CG17801 / 42144 FlyBaseID:FBgn0038550 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_001123992.1 Gene:ZNF195 / 7748 HGNCID:12986 Length:629 Species:Homo sapiens


Alignment Length:419 Identity:96/419 - (22%)
Similarity:149/419 - (35%) Gaps:96/419 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKPSQCHLCASCFCHLN---------------------PTIIFCLEVLAKIKDLTGIWLEQNERQ 48
            :||.:|..|...|..|:                     .|.|.|                .:..:
Human   241 EKPFKCQECGKSFQMLSFLTEHQKIHTGKKFQKCGECGKTFIQC----------------SHFTE 289

  Fly    49 PRHI--------CPSCLNDLNT-SIKLKKRIQ------------RVHNEAT--LRRESGLD---- 86
            |.:|        |..|.|.:.| |:..|.||.            :|.|:.:  ...|.|.:    
Human   290 PENIDTGEKPYKCQECNNVIKTCSVLTKNRIYAGGEHYRCEEFGKVFNQCSHLTEHEHGTEEKPC 354

  Fly    87 --EDLEST-VSDIEPEGDSSDLESEESYDSENY--PFDKKAEESDIDLNLAHEDRRNE-PHNPYD 145
              |:..|. :|..........|..|:....|.:  .|:.....|        :.:||| ...|:.
Human   355 KYEECSSVFISCSSLSNQQMILAGEKLSKCETWYKGFNHSPNPS--------KHQRNEIGGKPFK 411

  Fly   146 -SETPLIFKHKNPLIETPSFANENLPNKVD------AKSPKKGNFIQIGTDLRLLTTYPSIKVVK 203
             .|...|||..:.|.:.........|.|.|      .:|.......:|.|..:........||.:
Human   412 CEECDSIFKWFSDLTKHKRIHTGEKPYKCDECGKAYTQSSHLSEHRRIHTGEKPYQCEECGKVFR 476

  Fly   204 PLALAPEDVAAENVPPAKRTARKMQSLVCPKCGRVFKTPYNLKTHMVRHTGEKNFPCTFCDKRFV 268
                     ...::...|||..:.:...|.:||.:||...:|..|...|||||.:.|..|.|.|.
Human   477 ---------TCSSLSNHKRTHSEEKPYTCEECGNIFKQLSDLTKHKKTHTGEKPYKCDECGKNFT 532

  Fly   269 TKYLARLHERVRHMGEQPFECNFCSATFFTSTAKSSHERIRHIRDLRYQCDQCTKRFNTKTCLNK 333
            ......:|:|: |.||:|::|..|...|...:..:.|:: .|..:..|:||:|.|.|...:.|..
Human   533 QSSNLIVHKRI-HTGEKPYKCEECGRVFMWFSDITKHKK-THTGEKPYKCDECGKNFTQSSNLIV 595

  Fly   334 HKFLHSGLKPFDCVICQINFARKATLRSH 362
            ||.:|:|.||:.|..|...|.:.:.|..|
Human   596 HKRIHTGEKPYKCEKCGKAFTQFSHLTVH 624

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17801NP_650660.2 zf-AD 9..74 CDD:285071 17/106 (16%)
zf-C2H2 231..252 CDD:278523 7/20 (35%)
C2H2 Zn finger 232..252 CDD:275368 7/19 (37%)
zf-H2C2_2 244..269 CDD:290200 11/24 (46%)
C2H2 Zn finger 260..281 CDD:275368 6/20 (30%)
C2H2 Zn finger 289..308 CDD:275368 4/18 (22%)
C2H2 Zn finger 318..338 CDD:275368 8/19 (42%)
C2H2 Zn finger 346..362 CDD:275368 4/15 (27%)
ZNF195NP_001123992.1 KRAB 4..64 CDD:214630
KRAB 4..43 CDD:279668
Spacer 76..243 0/1 (0%)
COG5048 225..629 CDD:227381 96/419 (23%)
C2H2 Zn finger 246..266 CDD:275368 4/19 (21%)
C2H2 Zn finger 274..294 CDD:275368 4/35 (11%)
C2H2 Zn finger 302..345 CDD:275368 10/42 (24%)
C2H2 Zn finger 384..404 CDD:275368 4/27 (15%)
C2H2 Zn finger 412..432 CDD:275368 5/19 (26%)
zf-H2C2_2 424..449 CDD:290200 4/24 (17%)
C2H2 Zn finger 440..460 CDD:275368 2/19 (11%)
zf-H2C2_2 452..477 CDD:290200 4/33 (12%)
C2H2 Zn finger 468..488 CDD:275368 4/28 (14%)
zf-H2C2_2 480..505 CDD:290200 7/24 (29%)
C2H2 Zn finger 496..516 CDD:275368 7/19 (37%)
zf-H2C2_2 508..533 CDD:290200 11/24 (46%)
C2H2 Zn finger 524..544 CDD:275368 6/20 (30%)
zf-H2C2_2 536..559 CDD:290200 8/23 (35%)
C2H2 Zn finger 552..572 CDD:275368 4/20 (20%)
zf-H2C2_2 567..589 CDD:290200 8/22 (36%)
C2H2 Zn finger 580..600 CDD:275368 8/19 (42%)
zf-H2C2_2 592..617 CDD:290200 10/24 (42%)
C2H2 Zn finger 608..628 CDD:275368 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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