DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17801 and ZNF8

DIOPT Version :9

Sequence 1:NP_650660.2 Gene:CG17801 / 42144 FlyBaseID:FBgn0038550 Length:381 Species:Drosophila melanogaster
Sequence 2:NP_066575.2 Gene:ZNF8 / 7554 HGNCID:13154 Length:575 Species:Homo sapiens


Alignment Length:354 Identity:86/354 - (24%)
Similarity:145/354 - (40%) Gaps:58/354 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EVLAKIKDLTGIWLEQNERQPRHICPSCLNDLNTSIKLKKRIQRVHNEATLRRESGLDEDLESTV 93
            ||:::::..|.:|:.  ||.....|.....            .|..::|: |:|.||        
Human    72 EVISQLEQGTELWVA--ERGTTQGCHPAWE------------PRSESQAS-RKEEGL-------- 113

  Fly    94 SDIEPEGDSSDLESEESYDSE-NYPFDKKAEESDIDLNLAHEDRRNEPHNPYDSETPLIFKHKNP 157
                ||.:.|.:...|.:.:: .||.....:......:||.:::.|...        |.|..|..
Human   114 ----PEEEPSHVTGREGFPTDAPYPTTLGKDRECQSQSLALKEQNNLKQ--------LEFGLKEA 166

  Fly   158 LIETPSFANENL-PNKVDAKSP------KKGNFIQIGTDLRLLTTYPSIKVVKPLALAPEDVAAE 215
            .::...:....| .|.|.:.||      .:|.::.. .|.::..:..:..:|.....:|.....|
Human   167 PVQDQGYKTLRLRENCVLSSSPNPFPEISRGEYLYT-YDSQITDSEHNSSLVSQQTGSPGKQPGE 230

  Fly   216 N----------VPPAKRTARKMQS--LVCPKCGRVFKTPYNLKTHMVRHTGEKNFPCTFCDKRFV 268
            |          :|..:.|..::|.  ..|..||:.|....:|..|...||||:.:.|..|.|.|.
Human   231 NSDCHRDSSQAIPITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFS 295

  Fly   269 TKYLARLHERVRHMGEQPFECNFCSATFFTSTAKSSHERIRHIRDLRYQCDQCTKRFNTKTCLNK 333
            .......|||: |.|::|::|..|..:|..||..:.|.|| |..:..|:|..|.:.||..:.|.:
Human   296 QNSSLVQHERI-HTGDKPYKCAECGKSFCHSTHLTVHRRI-HTGEKPYECQDCGRAFNQNSSLGR 358

  Fly   334 HKFLHSGLKPFDCVICQINFARKATLRSH 362
            ||..|:|.||:.|.:|..:|:|...|..|
Human   359 HKRTHTGEKPYTCSVCGKSFSRTTCLFLH 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17801NP_650660.2 zf-AD 9..74 CDD:285071 8/44 (18%)
zf-C2H2 231..252 CDD:278523 6/20 (30%)
C2H2 Zn finger 232..252 CDD:275368 6/19 (32%)
zf-H2C2_2 244..269 CDD:290200 10/24 (42%)
C2H2 Zn finger 260..281 CDD:275368 7/20 (35%)
C2H2 Zn finger 289..308 CDD:275368 6/18 (33%)
C2H2 Zn finger 318..338 CDD:275368 7/19 (37%)
C2H2 Zn finger 346..362 CDD:275368 5/15 (33%)
ZNF8NP_066575.2 KRAB 25..85 CDD:214630 3/12 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 92..130 11/62 (18%)
COG5048 <167..404 CDD:227381 61/224 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..237 4/26 (15%)
C2H2 Zn finger 259..279 CDD:275368 6/19 (32%)
C2H2 Zn finger 287..307 CDD:275368 7/20 (35%)
C2H2 Zn finger 315..335 CDD:275368 8/20 (40%)
C2H2 Zn finger 343..363 CDD:275368 7/19 (37%)
C2H2 Zn finger 371..391 CDD:275368 6/17 (35%)
zf-C2H2 397..419 CDD:306579
C2H2 Zn finger 399..419 CDD:275368
zf-C2H2 467..489 CDD:306579
C2H2 Zn finger 469..489 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..533
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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