Protein Alignment CG17801 and Plag1

DIOPT Version :10

• Sequence 1: NP_650660.2
• Gene: CG17801 / 42144
• FlyBaseID: FBgn0038550
• Length: 381
• Species: Drosophila melanogaster
• Sequence 2: NP_064353.2
• Gene: Plag1 / 56711
• MGIID: 1891916
• Length: 499
• Species: Mus musculus
• Alignment Length: 183
• Identity: 50/183 - (27%)
• Similarity: 81/183 - (44%)
• Gaps: 13/183 - (7%)

  Fly   209 PEDVA----AENVPPAKR---TARKMQSLVCPKCGRVFKTPYNLKTHMVRHTGEKNFPCTF--CD 264
            |.|::    .:..|..||   .::..::..|..|.:.|.:...||.|...||||:.:.||.  |.
Mouse     6 PGDLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCT 70

  Fly   265 KRFVTKYLARLHERVRHMGEQPFECNFCSATFFTSTAKSSHERIRHIRDLRYQCDQCTKRFNTKT 329
            |.||:||..:.| ...|..|:..:||:|...|.......:|..........::|::|.|.:|||.
Mouse    71 KAFVSKYKLQRH-MATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKL 134

  Fly   330 CLNKHKFLHSGLK-PFDCVICQINFARKATLRSHFDSVAHQKRASAILESEEH 381
            ...:|..||:... ...|.:|..||.....|..|..|  |..::|..::.::|
Mouse   135 GFKRHLALHAATSGDLTCKVCLQNFESTGVLLEHLKS--HAGKSSGGVKEKKH 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17801	NP_650660.2	zf-AD	9..76	CDD:462262
		zf-C2H2	231..252	CDD:395048	6/20 (30%)
		C2H2 Zn finger	232..252	CDD:275368	6/19 (32%)
		zf-H2C2_2	244..269	CDD:463886	12/26 (46%)
		C2H2 Zn finger	260..281	CDD:275368	9/22 (41%)
		C2H2 Zn finger	289..308	CDD:275368	5/18 (28%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		C2H2 Zn finger	346..362	CDD:275368	5/15 (33%)
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		5/26 (19%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		24/78 (31%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		2/2 (100%)
		C2H2 Zn finger	36..56	CDD:275368	6/19 (32%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		43/148 (29%)
		SFP1	<58..139	CDD:227516	24/81 (30%)
		C2H2 Zn finger	64..86	CDD:275368	9/22 (41%)
		zf-H2C2_2	79..101	CDD:463886	6/22 (27%)
		C2H2 Zn finger	94..114	CDD:275368	5/19 (26%)
		C2H2 Zn finger	123..143	CDD:275368	7/19 (37%)
		C2H2 Zn finger	152..172	CDD:275368	7/21 (33%)
		C2H2 Zn finger	187..207	CDD:275368
		C2H2 Zn finger	215..233	CDD:275368
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..400
		Massively activates transcription. /evidence=ECO:0000250	384..499