DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF496

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_116141.1	Gene:	ZNF496 / 84838	HGNCID:	23713	Length:	587	Species:	Homo sapiens

Alignment Length:	471	Identity:	110/471 - (23%)
Similarity:	172/471 - (36%)	Gaps:	110/471 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQCRLCGDLIYTQNPVNIFDENSKMVRQIALVTGLWLTDHSKMP-RNMCSCCLLSLKSAIAFRQA 66
            |..:|.||.: .|:...:.:||   ||....||.|.|......| ::|..|.
Human   183 PPSQLSGDPV-LQDAFLLQEEN---VRDTQQVTTLQLPPSRVSPFKDMILCF------------- 230

  Fly    67 CIKTNNRLTIQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQEVLYEVSYADNEGLEEDHDLYK 131
                            :::|....||......|..|...:      |.||...|: |....||.:
Human   231 ----------------SEEDWSLLDPAQTGFYGEFIIGED------YGVSMPPND-LAAQPDLSQ 272

  Fly   132 KEEEESEVNENKEFEDIACEIP-FSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEESQPDEE- 194
            .||.|..|.|.::.:  ..|:| .|..|....|..:.|:.  :|.......|.|.|.::...:.
Human   273 GEENEPRVPELQDLQ--GKEVPQVSYLDSPSLQPFQVEER--RKREELQVPEFQACPQTVVPQNT 333

  Fly   195 -------ESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTK 252
                   .|.:|..|||.:    .|:..:..||.|:........|..|          |..|  :
Human   334 YPAGGNPRSLENSLDEEVT----IEIVLSSSGDEDSQHGPYCTEELGS----------PTEK--Q 382

  Fly   253 RSSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHV-LRHSGVKPFECPECGQK 316
            ||.|.:..:.    .:...:...|:|.::|.:|||.|..:.||..|: .|....||.||..||:.
Human   383 RSLPASHRSS----TEAGGEVQTSKKSYVCPNCGKIFRWRVNFIRHLRSRREQEKPHECSVCGEL 443

  Fly   317 EFNRYILNIHIRVKHRGEKPYACQFCDERF-VHSTMRSRHENRVH-------------------- 360
            ..:...|:.|:. .|..:|||.|..|.:.| ::|.:.|  ..|:|
Human   444 FSDSEDLDGHLE-SHEAQKPYRCGACGKSFRLNSHLLS--HRRIHLQPDRLQPVEKREQAASEDA 505

  Fly   361 --------RNKKTPKNFKCNYCDKRYESNYQRAKHEV-VHTGE--RNFHCEVCKVSFTRNSNLKT 414
                    .|.|...:|:|..|.|.::.:...|:|.. .|..:  |.|.|..|..|||:|.:|..
Human   506 DKGPKEPLENGKAKLSFQCCECGKAFQRHDHLARHRSHFHLKDKARPFQCRYCVKSFTQNYDLLR 570

  Fly   415 HYRSRQHQNKLIAMSA 430
            |.|....:....|:::
Human   571 HERLHMKRRSKQALNS 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	15/70 (21%)
		C2H2 Zn finger	282..302	CDD:275368	8/20 (40%)
		C2H2 Zn finger	310..331	CDD:275368	5/20 (25%)
		C2H2 Zn finger	339..360	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	9/22 (41%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ZNF496	NP_116141.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		SCAN	50..126	CDD:280241
		KRAB_A-box	222..259	CDD:143639	10/71 (14%)
		KRAB	223..275	CDD:214630	14/87 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..282		8/22 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	358..399		10/56 (18%)
		C2H2 Zn finger	408..428	CDD:275368	8/19 (42%)
		COG5048	<427..>586	CDD:227381	41/161 (25%)
		C2H2 Zn finger	437..457	CDD:275368	5/20 (25%)
		zf-C2H2	463..485	CDD:278523	7/23 (30%)
		C2H2 Zn finger	465..485	CDD:275368	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..513		0/24 (0%)
		zf-C2H2	522..543	CDD:278523	6/20 (30%)
		C2H2 Zn finger	524..543	CDD:275368	5/18 (28%)
		zf-C2H2	553..575	CDD:278523	10/21 (48%)
		C2H2 Zn finger	555..575	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050