DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF577

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001357376.1	Gene:	ZNF577 / 84765	HGNCID:	28673	Length:	485	Species:	Homo sapiens

Alignment Length:	372	Identity:	91/372 - (24%)
Similarity:	139/372 - (37%)	Gaps:	100/372 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 IQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQE-VLYEVSYADNEGLEEDHDLYKKEEEESEV 139
            ||.|....||        |||..|...:...:::: .|..|.|         |...|....:|::
Human    98 IQSRRYAGKD--------SDAFGGYGRSCLHIKRDKTLTGVKY---------HRCVKPSSPKSQL 145

  Fly   140 NE-------NKEFEDIACEIPFSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEE-SQPDEEES 196
            |:       .|..|...|...||::....:.|:.           :.||:...|.| .:....:.
Human   146 NDLQKICAGGKPHECSVCGRAFSRKAQLIQHQRT-----------ERGEKPHGCGECGKTFMRKI 199

  Fly   197 QQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDT 261
            |..|.....:.|...|.  :|.|            :|.||:|.|
Human   200 QLTEHQRTHTGEKPHEC--SECG------------KAFSRKSQL--------------------- 229

  Fly   262 DFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIH 326
                  ...::|:..:|.:.|..|||.|:.|...|.|...|:|.|.:.|..||:....:..|..|
Human   230 ------MVHQRTHTGEKPYRCSKCGKAFSRKCRLNRHQRSHTGEKLYGCSVCGKAFSQKAYLTAH 288

  Fly   327 IRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVH 391
            .|: |.|:|||.|..|...|...:..:||: |:|..:|.   ::|:.|:|.:.|..:..:|:..|
Human   289 QRL-HTGDKPYKCSDCGRTFYFKSDLTRHQ-RIHTGEKP---YECSECEKAFRSKSKLIQHQRTH 348

  Fly   392 TGERNFHCEVCKVSFTRNSNL----KTHYR-------------SRQH 421
            ||||.:.|..|..:|...|.|    |||.|             ||.|
Human   349 TGERPYSCRECGKAFAHMSVLIKHEKTHIRETAINSLTVEKPSSRSH 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..331	CDD:275368	6/20 (30%)
		C2H2 Zn finger	339..360	CDD:275368	6/20 (30%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	11/39 (28%)
		C2H2 Zn finger	399..417	CDD:275368	8/21 (38%)
ZNF577	NP_001357376.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		KRAB	25..83	CDD:214630
		COG5048	136..>217	CDD:227381	17/93 (18%)
		C2H2 Zn finger	160..180	CDD:275368	4/30 (13%)
		C2H2 Zn finger	188..208	CDD:275368	4/19 (21%)
		COG5048	<194..399	CDD:227381	65/248 (26%)
		C2H2 Zn finger	216..236	CDD:275368	7/60 (12%)
		C2H2 Zn finger	244..264	CDD:275368	8/19 (42%)
		C2H2 Zn finger	272..292	CDD:275368	6/20 (30%)
		C2H2 Zn finger	300..320	CDD:275368	6/20 (30%)
		C2H2 Zn finger	328..348	CDD:275368	5/19 (26%)
		C2H2 Zn finger	356..376	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960