Protein Alignment Nnk and ZKSCAN3

DIOPT Version :10

• Sequence 1: NP_650659.2
• Gene: Nnk / 42143
• FlyBaseID: FBgn0038549
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_077819.2
• Gene: ZKSCAN3 / 80317
• HGNCID: 13853
• Length: 538
• Species: Homo sapiens
• Alignment Length: 456
• Identity: 106/456 - (23%)
• Similarity: 164/456 - (35%)
• Gaps: 147/456 - (32%)

  Fly    52 CCLLSLKSAIAFRQACIKTNNRLTIQRRSVEAKDDGCWADPLSD--------AHEGLKINDAEVE 108
            ||.::|.:.....|:.       ..|......|.:...:.||.|        ||.|....|..|.
Human   146 CCKMALLTPAPGSQSS-------QFQLMKALLKHESVGSQPLQDRVLQVPVLAHGGCCREDKVVA 203

  Fly   109 QEVLYEVSYADNEGLEEDHDLYKKEEEESEVNENKEFEDIACEI--PFSKEDDEQ------EQQQ 165
            ..:..|     ::||                   .:.||:|..:  .::::|..|      |:|:
Human   204 SRLTPE-----SQGL-------------------LKVEDVALTLTPEWTQQDSSQGNLCRDEKQE 244

  Fly   166 EYEDMVDKKTGHDDGEESQECEESQPDEEESQQNEEDE---------------EESQEDDDELWQ 215
            .:..:|..      |:|.|......|..||..:.|..:               .|:.|.:..|.:
Human   245 NHGSLVSL------GDEKQTKSRDLPPAEELPEKEHGKISCHLREDIAQIPTCAEAGEQEGRLQR 303

  Fly   216 -------------NEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDFLKP- 266
                         :|.|.|...:..:|               |.||.:|..           ||
Human   304 KQKNATGGRRHICHECGKSFAQSSGLS---------------KHRRIHTGE-----------KPY 342

  Fly   267 -AKKKRKTYIS-------QKVHI------CDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKE 317
             .::..|.:|.       |:||.      |:.|||.|:...:...|...|:|.||:||.:||:..
Human   343 ECEECGKAFIGSSALVIHQRVHTGEKPYECEECGKAFSHSSDLIKHQRTHTGEKPYECDDCGKTF 407

  Fly   318 FNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVH---------------------- 360
            .....|..|.|: |.|||||.|..|.:.|..|:...||: |:|
Human   408 SQSCSLLEHHRI-HTGEKPYQCSMCGKAFRRSSHLLRHQ-RIHTGDKNVQEPEQGEAWKSRMESQ 470

  Fly   361 -RNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQNK 424
             .|.:||.::|||.|::.:..|....:|:.:||||:.:.|..|...|||.|.|..|.||...:|.
Human   471 LENVETPMSYKCNECERSFTQNTGLIEHQKIHTGEKPYQCNACGKGFTRISYLVQHQRSHVGKNI 535

  Fly   425 L 425
            |
Human   536 L 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nnk	NP_650659.2	zf-AD	4..74	CDD:214871	4/21 (19%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	6/20 (30%)
		C2H2 Zn finger	339..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	397..421	CDD:463736	10/23 (43%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ZKSCAN3	NP_077819.2	SCAN	42..154	CDD:128708	3/7 (43%)
		KRAB	214..274	CDD:214630	14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	226..274		11/53 (21%)
		zf-C2H2	314..336	CDD:395048	7/36 (19%)
		C2H2 Zn finger	316..336	CDD:275368	7/34 (21%)
		zf-H2C2_2	329..351	CDD:463886	8/47 (17%)
		zf-C2H2	342..364	CDD:395048	3/21 (14%)
		C2H2 Zn finger	344..364	CDD:275368	3/19 (16%)
		COG5048	<368..515	CDD:227381	46/148 (31%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	6/20 (30%)
		C2H2 Zn finger	428..448	CDD:275368	7/20 (35%)
		C2H2 Zn finger	482..502	CDD:275368	5/19 (26%)
		zf-C2H2	508..530	CDD:395048	9/21 (43%)
		C2H2 Zn finger	510..530	CDD:275368	9/19 (47%)