DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZKSCAN1

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001333510.1	Gene:	ZKSCAN1 / 7586	HGNCID:	13101	Length:	563	Species:	Homo sapiens

Alignment Length:	338	Identity:	93/338 - (27%)
Similarity:	145/338 - (42%)	Gaps:	50/338 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 HEGLKINDAEVEQEVLYEVSYADNEGLEEDHDLYKKEEEESEVNENKEFEDIACEIPFSKEDDEQ 161
            |||     :..:|.:...:..||::.:.:..|:          ..:...|:..|:....:.....
Human   205 HEG-----SPRDQAMASALFTADSQAMVKIEDM----------AVSLILEEWGCQNLARRNLSRD 254

  Fly   162 EQQQEYEDMVDKKTGHDDGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDAD 226
            .:|:.|.....:     .||...|.|||....|.|:.:....|.:.....|..:..|.:..|...
Human   255 NRQENYGSAFPQ-----GGENRNENEESTSKAETSEDSASRGETTGRSQKEFGEKRDQEGKTGER 314

  Fly   227 SMSDIEATSRQS------ALDEDKK-------PRRKYTKRSSPKNDDTDFLKPAKKKRKTYISQK 278
            ...:.|..:|:.      |:.:|||       ||.|........:..::|..|.:....|    |
Human   315 QQKNPEEKTRKEKRDSGPAIGKDKKTITGERGPREKGKGLGRSFSLSSNFTTPEEVPTGT----K 375

  Fly   279 VHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILN----IHIRVKHRGEKPYAC 339
            .|.||.|||.||...:...|.:.|:|.||:||.||| |.|:   ||    :|.|: |.||||:.|
Human   376 SHRCDECGKCFTRSSSLIRHKIIHTGEKPYECSECG-KAFS---LNSNLVLHQRI-HTGEKPHEC 435

  Fly   340 QFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKV 404
            ..|.:.|.||:....|: |:|..:|.   ::||.|.|.:..:....||:.:||||:.:.|..|..
Human   436 NECGKAFSHSSNLILHQ-RIHSGEKP---YECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGK 496

  Fly   405 SFTRNSNLKTHYR 417
            :|.|||.|..|.|
Human   497 AFNRNSYLILHRR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..331	CDD:275368	10/24 (42%)
		C2H2 Zn finger	339..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	371..388	CDD:275370	5/16 (31%)
		zf-met	398..421	CDD:289631	9/20 (45%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ZKSCAN1	NP_001333510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		SCAN	52..162	CDD:128708
		KRAB_A-box	227..262	CDD:143639	5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..373		25/120 (21%)
		C2H2 Zn finger	355..371	CDD:275368	2/15 (13%)
		COG5048	<356..537	CDD:227381	61/167 (37%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	407..427	CDD:275368	10/24 (42%)
		C2H2 Zn finger	435..455	CDD:275368	7/20 (35%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		C2H2 Zn finger	491..511	CDD:275368	9/19 (47%)
		C2H2 Zn finger	519..539	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960