DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17802 and ZNF10

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_056209.2	Gene:	ZNF10 / 7556	HGNCID:	12879	Length:	573	Species:	Homo sapiens

Alignment Length:	376	Identity:	90/376 - (23%)
Similarity:	150/376 - (39%)	Gaps:	90/376 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 EGLKINDAEVEQEVLYEVSYADNEGLEEDHDLYKKEEE---------------ESEVNENKEFED 147
            ||:..||       |:.:|..:.....:..|.|::..|               :..|:|:.::..
Human   114 EGMARND-------LWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGG 171

  Fly   148 IACEIP--------FSKEDDEQEQQQEYEDMVDKKTGHDD--GEESQECEESQPDE----EESQQ 198
             .|.:|        |.|.|...:..:  .|:|  ..||.|  ...|.||.::....    :.::.
Human   172 -NCLLPAQLVLREYFHKRDSHTKSLK--HDLV--LNGHQDSCASNSNECGQTFCQNIHLIQFART 231

  Fly   199 NEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDF 263
            :..|:.....|:|        :|.|...|:...:...|:... |.|:..:.::.||:
Human   232 HTGDKSYKCPDND--------NSLTHGSSLGISKGIHREKPY-ECKECGKFFSWRSN-------- 279

  Fly   264 LKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYI-LNIHI 327
               ..:.:..:..:|.:.|..|||.|:...:...|...|:|.:|:||.||| |.|:.:. |..|.
Human   280 ---LTRHQLIHTGEKPYECKECGKSFSRSSHLIGHQKTHTGEEPYECKECG-KSFSWFSHLVTHQ 340

  Fly   328 RVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKK------TPKNFK---------------- 370
            |. |.|:|.|.|..|.:.||||:...||: |.|..:|      ..|:|:
Human   341 RT-HTGDKLYTCNQCGKSFVHSSRLIRHQ-RTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVR 403

  Fly   371 ---CNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRS 418
               ||.|.|.|........|..:|||.:.|.|:.|...|:|:|:|.:|.|:
Human   404 PYECNECGKSYSQRSHLVVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRT 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	9/21 (43%)
		C2H2 Zn finger	339..360	CDD:275368	9/20 (45%)
		C2H2 Zn finger	371..388	CDD:275370	5/16 (31%)
		zf-met	398..421	CDD:289631	8/21 (38%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
ZNF10	NP_056209.2	KRAB	14..73	CDD:214630
		C2H2 Zn finger	213..232	CDD:275368	2/18 (11%)
		C2H2 Zn finger	267..287	CDD:275368	3/30 (10%)
		COG5048	<272..474	CDD:227381	57/197 (29%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275368	9/21 (43%)
		C2H2 Zn finger	351..371	CDD:275368	9/20 (45%)
		C2H2 Zn finger	379..399	CDD:275368	2/19 (11%)
		C2H2 Zn finger	407..427	CDD:275368	6/19 (32%)
		C2H2 Zn finger	435..455	CDD:275368	8/20 (40%)
		C2H2 Zn finger	463..483	CDD:275368
		C2H2 Zn finger	491..511	CDD:275368
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050