DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF3

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001305065.1	Gene:	ZNF3 / 7551	HGNCID:	13089	Length:	453	Species:	Homo sapiens

Alignment Length:	327	Identity:	84/327 - (25%)
Similarity:	141/327 - (43%)	Gaps:	50/327 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 EVEQEVLYEVSYADNEGLEEDHDLYKKEEEESEVNENKEF---------EDIACEIPFSKEDDEQ 161
            |..|..||.....:|.|.....|...:.|.:.|::|:...         :||:..:.|
Human    76 EPAQRDLYRDVMLENYGNVFSLDRETRTENDQEISEDTRSHGVLLGRFQKDISQGLKF------- 133

  Fly   162 EQQQEYEDMVDKKTGHDDGEESQECEESQPD------EEESQQNEEDEEESQEDDDELWQNEDGD 220
            ::..|.|..:.:..|:..||   ......||      ||:.....|..|:         .|:.|:
Human   134 KEAYEREVSLKRPLGNSPGE---RLNRKMPDFGQVTVEEKLTPRGERSEK---------YNDFGN 186

  Fly   221 SDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDFLKPAKKKRKTYISQKVHICDHC 285
            |.|...::     .|.| .|....:| .|..:.|...|..:|.:    :.::.:..:|.:.|:.|
Human   187 SFTVNSNL-----ISHQ-RLPVGDRP-HKCDECSKSFNRTSDLI----QHQRIHTGEKPYECNEC 240

  Fly   286 GKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHST 350
            ||.|:...:...|...|:|.||:||.:||:.......|.:|.|: |.|||||.|..|.:.|..|:
Human   241 GKAFSQSSHLIQHQRIHTGEKPYECSDCGKTFSCSSALILHRRI-HTGEKPYECNECGKTFSWSS 304

  Fly   351 MRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTH 415
            ..:.|: |:|..:|.   :.||.|.|.:..:.....|:.:||||:.:.|..|..:|:::|:|..|
Human   305 TLTHHQ-RIHTGEKP---YACNECGKAFSRSSTLIHHQRIHTGEKPYECNECGKAFSQSSHLYQH 365

  Fly   416 YR 417
            .|
Human   366 QR 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	6/20 (30%)
		C2H2 Zn finger	339..360	CDD:275368	6/20 (30%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	7/20 (35%)
		C2H2 Zn finger	399..417	CDD:275368	6/17 (35%)
ZNF3	NP_001305065.1	KRAB	57..98	CDD:366587	6/21 (29%)
		COG5048	<182..360	CDD:227381	56/193 (29%)
		C2H2 Zn finger	185..201	CDD:275368	5/21 (24%)
		C2H2 Zn finger	209..229	CDD:275368	3/23 (13%)
		C2H2 Zn finger	237..257	CDD:275368	6/19 (32%)
		C2H2 Zn finger	265..285	CDD:275368	6/20 (30%)
		C2H2 Zn finger	293..313	CDD:275368	6/20 (30%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		zf-H2C2_2	361..386	CDD:372612	3/7 (43%)
		C2H2 Zn finger	377..397	CDD:275368
		zf-H2C2_2	390..414	CDD:372612
		C2H2 Zn finger	405..425	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960