DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF735

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001152996.1	Gene:	ZNF735 / 730291	HGNCID:	32466	Length:	412	Species:	Homo sapiens

Alignment Length:	313	Identity:	78/313 - (24%)
Similarity:	132/313 - (42%)	Gaps:	70/313 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 KEEEESEVNENKEFEDIACEIPFSKEDDEQEQQQEYEDMVDK-------KTGHDDGEESQECEES 189
            ||.:..:.||......:.|    |..:.:.:.:|..:|.:.|       |.||::.:..:.|:..
Human    72 KEPQNIKRNEMAAKHPVTC----SHFNQDLQPEQSIKDSLQKVIPRTYGKCGHENLQLKKCCKRV 132

  Fly   190 QPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTD---ADSMSDIEATSR----QSALDEDKKPR 247
                                 ||...::.|.:|.:   :::.:.|..|.:    .|......:..
Human   133 ---------------------DECEVHKGGYNDLNQCLSNTQNKIFQTHKCVKVFSKFSNSNRHN 176

  Fly   248 RKYTKRSSPKNDDTDFLKPAKKKRKTY-------------ISQKVHICDHCGKKFTDKGNFNLHV 299
            .:||.:...|         .||..|::             ..:|.:.|:.|||.|....:...|.
Human   177 ARYTGKKHLK---------CKKYGKSFCMFSHLNQHQIIHTKEKSYKCEECGKSFNHSSSGTTHK 232

  Fly   300 LRHSGVKPFECPECGQKEFNRYILNI--HIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRN 362
            ...:|.||:.|.||| |.| |:..|:  |.|: |.|||||||:.|.:.|..|:..:.|: |:|..
Human   233 RILTGEKPYRCEECG-KAF-RWPSNLTRHKRI-HTGEKPYACEECGQAFRRSSTLTNHK-RIHTG 293

  Fly   363 KKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTH 415
            ::.   :||..|.|.:..:.....|:.:||||:.:.||.|..:|..:|.||||
Human   294 ERP---YKCEECGKAFSVSSALIYHKRIHTGEKPYTCEECGKAFNCSSTLKTH 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	10/22 (45%)
		C2H2 Zn finger	339..360	CDD:275368	6/20 (30%)
		C2H2 Zn finger	371..388	CDD:275370	3/16 (19%)
		zf-met	398..421	CDD:289631	9/18 (50%)
		C2H2 Zn finger	399..417	CDD:275368	9/17 (53%)
ZNF735	NP_001152996.1	KRAB	16..76	CDD:214630	2/3 (67%)
		KRAB	16..55	CDD:279668
		C2H2 Zn finger	160..179	CDD:275368	1/18 (6%)
		COG5048	<167..372	CDD:227381	59/193 (31%)
		C2H2 Zn finger	187..207	CDD:275368	3/19 (16%)
		zf-H2C2_2	199..224	CDD:290200	6/24 (25%)
		C2H2 Zn finger	215..235	CDD:275368	6/19 (32%)
		C2H2 Zn finger	243..263	CDD:275368	10/22 (45%)
		zf-H2C2_2	255..280	CDD:290200	13/25 (52%)
		C2H2 Zn finger	271..291	CDD:275368	6/20 (30%)
		zf-H2C2_2	284..307	CDD:290200	7/26 (27%)
		C2H2 Zn finger	299..319	CDD:275368	4/19 (21%)
		zf-H2C2_2	311..336	CDD:290200	9/24 (38%)
		C2H2 Zn finger	327..347	CDD:275368	9/17 (53%)
		zf-H2C2_2	340..364	CDD:290200	4/4 (100%)
		COG5048	<351..>412	CDD:227381
		C2H2 Zn finger	355..375	CDD:275368
		zf-H2C2_2	368..391	CDD:290200
		C2H2 Zn finger	383..403	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050