DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17802 and ZNF649

DIOPT Version :9

Sequence 1:NP_650659.2 Gene:CG17802 / 42143 FlyBaseID:FBgn0038549 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_075562.2 Gene:ZNF649 / 65251 HGNCID:25741 Length:505 Species:Homo sapiens


Alignment Length:321 Identity:83/321 - (25%)
Similarity:127/321 - (39%) Gaps:50/321 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   137 SEVNENKEFEDIACEI---------PFSKEDDEQEQQQEYEDMVDKKTGHDDGEES--QECEESQ 190
            ::..|:...||:|.:.         |..|:.......:.|.::|  ..|:..|:..  .:.|:.:
Human     2 TKAQESLTLEDVAVDFTWEEWQFLSPAQKDLYRDVMLENYSNLV--SVGYQAGKPDALTKLEQGE 64

  Fly   191 P-----DEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKY 250
            |     ||..|..:.|.|:.    ||.|.|...................:.:|.|....:.||..
Human    65 PLWTLEDEIHSPAHPEIEKA----DDHLQQPLQNQKILKRTGQRYEHGRTLKSYLGLTNQSRRYN 125

  Fly   251 TKRSSPKNDDTDFL-----------------KPAK------KKRKTYISQKVHICDHCGKKFTDK 292
            .|..:..|.|..||                 ||..      |.::|:..:|.|.|..|||.|..|
Human   126 RKEPAEFNGDGAFLHDNHEQMPTEIEFPESRKPISTKSQFLKHQQTHNIEKAHECTDCGKAFLKK 190

  Fly   293 GNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHEN 357
            .....|...|:|.||..|..||:..:.:|.|..|.|. ||||||:.|..|.:.|......:.|| 
Human   191 SQLTEHKRIHTGKKPHVCSLCGKAFYKKYRLTEHERA-HRGEKPHGCSLCGKAFYKRYRLTEHE- 253

  Fly   358 RVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRS 418
            |.|:.:|.   :.|:.|.|.:....:..:|:.:|||.:...|..|..:|:|.|.|..|.|:
Human   254 RAHKGEKP---YGCSECGKAFPRKSELTEHQRIHTGIKPHQCSECGRAFSRKSLLVVHQRT 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17802NP_650659.2 zf-AD 4..74 CDD:285071
C2H2 Zn finger 282..302 CDD:275368 7/19 (37%)
C2H2 Zn finger 310..331 CDD:275368 7/20 (35%)
C2H2 Zn finger 339..360 CDD:275368 6/20 (30%)
C2H2 Zn finger 371..388 CDD:275370 3/16 (19%)
zf-met 398..421 CDD:289631 8/21 (38%)
C2H2 Zn finger 399..417 CDD:275368 7/17 (41%)
ZNF649NP_075562.2 KRAB 8..68 CDD:214630 11/61 (18%)
KRAB 8..47 CDD:279668 7/40 (18%)
C2H2 Zn finger 180..200 CDD:275368 7/19 (37%)
zf-H2C2_2 193..215 CDD:290200 8/21 (38%)
C2H2 Zn finger 208..228 CDD:275368 7/20 (35%)
C2H2 Zn finger 236..256 CDD:275368 6/20 (30%)
COG5048 260..>321 CDD:227381 16/55 (29%)
C2H2 Zn finger 264..284 CDD:275368 4/19 (21%)
zf-H2C2_2 276..301 CDD:290200 7/24 (29%)
C2H2 Zn finger 292..312 CDD:275368 8/20 (40%)
zf-H2C2_2 305..329 CDD:290200 3/7 (43%)
C2H2 Zn finger 320..340 CDD:275368
zf-H2C2_2 332..357 CDD:290200
C2H2 Zn finger 348..368 CDD:275368
C2H2 Zn finger 376..396 CDD:275368
zf-H2C2_2 389..413 CDD:290200
C2H2 Zn finger 404..424 CDD:275368
C2H2 Zn finger 432..452 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 455..481
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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