DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF286A

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001275571.1	Gene:	ZNF286A / 57335	HGNCID:	13501	Length:	564	Species:	Homo sapiens

Alignment Length:	458	Identity:	101/458 - (22%)
Similarity:	171/458 - (37%)	Gaps:	145/458 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 DAHEGLKINDAEVEQEVLYEVSYAD--NEGLEEDHD---LYKKEEEESEV---------NENKEF 145
            |.:.|.:.|....|:.|:.|...|:  .:|.....|   ..:|..||.||         .|...|
Human    26 DLNWGEEQNLQNKEEVVIMETDLAEMPEKGALSSQDSPHFQEKSTEEGEVAALRLTARSQETVTF 90

  Fly   146 EDIACE----------------------------IPFSKED-------------DEQEQQQEYED 169
            :|:|.:                            :|.||.:             :.:..:..|.|
Human    91 KDVAMDFTPEEWGKLDPAQRDVMLENYRNLVSLWLPVSKPESYNLENGKEPLKLERKAPKSSYSD 155

  Fly   170 MVDKKTGHD-----DGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNEDGDSD------- 222
            |..:....|     |..:::.|:.:..|........:...|:..:.:...:|:.|:.:
Human   156 METRPQSKDSTSVQDFSKAESCKVAIIDRLTRNSVYDSNLEAALECENWLENQQGNQERHLREMF 220

  Fly   223 TDADSMS-------DI--EATSRQSAL-DEDKKPRRKYTKRSSPKNDDTDFLKPAK---KKRKTY 274
            |..:|:|       |:  ::.:::|.| .||:.|:..|...:..|:     ||...   ||::||
Human   221 THMNSLSEETDHKHDVYWKSFNQKSVLITEDRVPKGSYAFHTLEKS-----LKQKSNLMKKQRTY 280

  Fly   275 ISQKVH----------------------------ICDHCGKKFTDKGNFNLHVLRHS-------- 303
            ..:|.|                            .|:.|||.|:.:.|...|...|:
Human   281 KEKKPHKCNDCGELFTYHSVLIRHQRVHTGEKPYTCNECGKSFSHRANLTKHQRTHTRILFECSE 345

  Fly   304 -------------------GVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHS 349
                               |.:|:||.||| |.|||....:..::.|.|.|||.|..||:.|:||
Human   346 CKKTFTESSSLATHQRIHVGERPYECNECG-KGFNRSTHLVQHQLIHTGVKPYECNECDKAFIHS 409

  Fly   350 TMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKT 414
            :...:|: |.|..:|.   :||..|.|.:.......||:.|||||:.:.|..|..:|:::::|..
Human   410 SALIKHQ-RTHTGEKP---YKCQECGKAFSHCSSLTKHQRVHTGEKPYECSECGKTFSQSTHLVQ 470

  Fly   415 HYR 417
            |.|
Human   471 HQR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	8/20 (40%)
		C2H2 Zn finger	339..360	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	6/20 (30%)
		C2H2 Zn finger	399..417	CDD:275368	5/17 (29%)
ZNF286A	NP_001275571.1	KRAB	88..141	CDD:214630	6/52 (12%)
		KRAB	88..123	CDD:279668	3/34 (9%)
		COG5048	<265..400	CDD:227381	33/140 (24%)
		C2H2 Zn finger	288..308	CDD:275368	0/19 (0%)
		zf-H2C2_2	301..325	CDD:290200	5/23 (22%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368	0/19 (0%)
		zf-H2C2_2	355..380	CDD:290200	9/25 (36%)
		C2H2 Zn finger	371..391	CDD:275368	8/20 (40%)
		zf-H2C2_2	383..406	CDD:290200	8/22 (36%)
		COG5048	<395..550	CDD:227381	30/83 (36%)
		zf-C2H2	397..419	CDD:278523	9/22 (41%)
		C2H2 Zn finger	399..419	CDD:275368	8/20 (40%)
		zf-H2C2_2	411..436	CDD:290200	8/28 (29%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		zf-H2C2_2	439..464	CDD:290200	10/24 (42%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		zf-H2C2_2	467..492	CDD:290200	3/7 (43%)
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	495..518	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..548	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050