DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17802 and Zif

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001189188.1	Gene:	Zif / 40795	FlyBaseID:	FBgn0037446	Length:	388	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	111/452 - (24%)
Similarity:	181/452 - (40%)	Gaps:	101/452 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTPQ-CRLC---GDLIYTQNPVNIFDENS--KMVRQIALVTGLWLTDHSKMPRNMCSCCLLSLKS 59
            :||| ||:|   .:.:...:.:....|.|  :|:.|:..|:...|.|...:|..:|..|.:.|..
  Fly     5 LTPQTCRVCLAQSERLQRLDEIREEGEESPNEMLIQLLGVSYSNLNDREHIPDGICKSCKVELNM 69

  Fly    60 AIAFRQACIKTNNRLTIQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQEVLYEVSYADNEGLE 124
            |..||:..::                                 ...|:|:       |....||.
  Fly    70 AYQFREKALR---------------------------------KQMEIEE-------YCRELGLL 94

  Fly   125 EDHDLYKKEEEESEVNENKEFEDIACEIPFSKEDDEQEQQ--QEYEDMVDKKTGHDDGEESQECE 187
            ::.|                       :...||:|..:||  :|...:.:..||.::.:|.:..|
  Fly    95 DESD-----------------------VMMIKEEDGSQQQCDEEMYILEETTTGEEEHQEEKGHE 136

  Fly   188 E-SQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEAT-SRQSALDE----DKKP 246
            | .:.|..:.|:...|..|..||:..:..|.| .::...:|....|.| |:|.||.|    ..|.
  Fly   137 EYLEVDTSDQQECIGDTIEYLEDNYTIEMNSD-QTEIVLESEKQYEETPSQQLALQEAAKASLKA 200

  Fly   247 RRKYTKR---SSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPF 308
            ||...:|   |...:|.|:              :..:|||.||..:..:|....|..||.|:..:
  Fly   201 RRGRVRRGLNSLTTSDGTE--------------KGGYICDVCGNFYEKRGRMMEHRRRHDGICQY 251

  Fly   309 ECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNY 373
            .|..|..|...|..|..|: ..|.|.|||.|.||..:|.:.::...||| |||..|.   :.|..
  Fly   252 ACELCDAKFQVREQLRKHM-YSHTGSKPYKCSFCSRQFFYESVLKSHEN-VHRGIKP---YVCKV 311

  Fly   374 CDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQNK-LIAMSAKSEI 434
            |||.:...:...|||::|:..:.:.|:.|...|....:::.|..::.|||. ::|.|.|.|:
  Fly   312 CDKAFAYAHSLTKHELIHSDIKLYRCDYCNKDFRLLHHMRQHEETKLHQNAVMLAESMKVEM 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	18/75 (24%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	6/20 (30%)
		C2H2 Zn finger	339..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	371..388	CDD:275370	5/16 (31%)
		zf-met	398..421	CDD:289631	4/22 (18%)
		C2H2 Zn finger	399..417	CDD:275368	4/17 (24%)
Zif	NP_001189188.1	zf-AD	9..87	CDD:285071	19/117 (16%)
		C2H2 Zn finger	225..245	CDD:275368	6/19 (32%)
		COG5048	<250..369	CDD:227381	38/123 (31%)
		C2H2 Zn finger	253..273	CDD:275368	6/20 (30%)
		zf-H2C2_2	266..288	CDD:290200	10/22 (45%)
		C2H2 Zn finger	281..301	CDD:275368	7/20 (35%)
		zf-H2C2_2	294..318	CDD:290200	11/27 (41%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..353	CDD:275368	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960