DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17802 and ZFP69

DIOPT Version :9

Sequence 1:NP_650659.2 Gene:CG17802 / 42143 FlyBaseID:FBgn0038549 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_001307107.1 Gene:ZFP69 / 339559 HGNCID:24708 Length:527 Species:Homo sapiens


Alignment Length:406 Identity:102/406 - (25%)
Similarity:161/406 - (39%) Gaps:94/406 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 DPLSDAHEGLKINDAE------VEQEVLY-----------EVSYADNEGLEEDHDLYKKEEE--- 135
            ||.||...  ||...|      :.||.||           ::.|:....:....|:.::.:|   
Human   145 DPSSDLKS--KIETIESTAKSTISQERLYHGIMMESFMRDDIIYSTLRKVSTYDDVLERHQETCM 207

  Fly   136 ----------ESEVNENKEF-------EDIACEIPFSKEDDEQEQQQEYEDMVDKKTGH--DDGE 181
                      :..|.|..:|       .::..|....|.|...::.....|:::..|.:  ....
Human   208 RDVRQAILTHKKRVQETNKFGENIIVHSNVIIEQRHHKYDTPTKRNTYKLDLINHPTSYIRTKTY 272

  Fly   182 ESQECEE--SQPDE-EESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDED 243
            |...||:  .||.. .|..:....|:..:       ..|.|.:.:.:.|:|..:.........|.
Human   273 ECNICEKIFKQPIHLTEHMRIHTGEKPFR-------CKECGRAFSQSASLSTHQRIHTGEKPFEC 330

  Fly   244 KKPRRKYTKRSSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPF 308
            ::..:.:..|||           ..:..:|:..:|.::||.|.|.|:...:...|:..|||.|||
Human   331 EECGKAFRHRSS-----------LNQHHRTHTGEKPYVCDKCQKAFSQNISLVQHLRTHSGEKPF 384

  Fly   309 ECPECGQKEFNRYI--LNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHE--------------- 356
            .|.||| |.| |.|  |:.|||: |.|||||||..|.:.|.|....:.|:               
Human   385 TCNECG-KTF-RQIRHLSEHIRI-HTGEKPYACTACCKTFSHRAYLTHHQRIHTGERPYKCKECG 446

  Fly   357 ----NRVH-RNKKT----PKNFKCNYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNL 412
                .|:| .|.||    .|.::||.|.|.|..:....||:..||||:.:.|..|..:|:.||:|
Human   447 KAFRQRIHLSNHKTVHTGVKAYECNRCGKAYRHDSSFKKHQRHHTGEKPYECNECGKAFSYNSSL 511

  Fly   413 KTH---YRSRQHQNKL 425
            ..|   :|....:||:
Human   512 SRHHEIHRRNAFRNKV 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17802NP_650659.2 zf-AD 4..74 CDD:285071
C2H2 Zn finger 282..302 CDD:275368 6/19 (32%)
C2H2 Zn finger 310..331 CDD:275368 12/22 (55%)
C2H2 Zn finger 339..360 CDD:275368 6/39 (15%)
C2H2 Zn finger 371..388 CDD:275370 6/16 (38%)
zf-met 398..421 CDD:289631 8/25 (32%)
C2H2 Zn finger 399..417 CDD:275368 7/20 (35%)
ZFP69NP_001307107.1 SCAN <3..66 CDD:383046
KRAB 76..137 CDD:214630
COG5048 <233..516 CDD:227381 82/303 (27%)
C2H2 Zn finger 274..294 CDD:275368 5/19 (26%)
C2H2 Zn finger 302..322 CDD:275368 4/19 (21%)
C2H2 Zn finger 330..350 CDD:275368 3/30 (10%)
C2H2 Zn finger 358..378 CDD:275368 6/19 (32%)
C2H2 Zn finger 386..406 CDD:275368 12/22 (55%)
C2H2 Zn finger 414..434 CDD:275368 5/19 (26%)
C2H2 Zn finger 442..462 CDD:275368 5/19 (26%)
C2H2 Zn finger 498..518 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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