DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF789

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_998768.2	Gene:	ZNF789 / 285989	HGNCID:	27801	Length:	425	Species:	Homo sapiens

Alignment Length:	358	Identity:	86/358 - (24%)
Similarity:	129/358 - (36%)	Gaps:	97/358 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KTNNRLTIQRRSVEAKDDGCWADPLSDA-HEGLKINDAEVEQEVL--YEVSYADNEGLEEDHDLY 130
            :|.||        :|....|   |.|:| |:..|:...:...|.|  |::|....|..|
Human    76 RTGNR--------KASGSAC---PGSEARHKMKKLTPKQKFSEDLESYKISVVMQESAE------ 123

  Fly   131 KKEEEESEVNENKEFEDIACEIPFSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEESQPDEEE 195
            |..|   ::::.|||.| :|.:.|....||..:
Human   124 KLSE---KLHKCKEFVD-SCRLTFPTSGDEYSR-------------------------------- 152

  Fly   196 SQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPKNDD 260
                            ...||.:...|.:|      :...:|...|||.||   :.:||.....:
Human   153 ----------------GFLQNLNLIQDQNA------QTRWKQGRYDEDGKP---FNQRSLLLGHE 192

  Fly   261 TDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNI 325
                       :.....|.:.|..|||....|..|:.|...|....||||..|||....|..|.:
Human   193 -----------RILTRAKSYECSECGKVIRRKAWFDQHQRIHFLENPFECKVCGQAFRQRSALTV 246

  Fly   326 HIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVV 390
            | :..|...|||.|..|.:.|........|: |:|..:|.   :||:.|:|.:..|....:|:|:
Human   247 H-KQCHLQNKPYRCHDCGKCFRQLAYLVEHK-RIHTKEKP---YKCSKCEKTFSQNSTLIRHQVI 306

  Fly   391 HTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQN 423
            |:||:...|..|..:|.|:|.|..|.:.....|
Human   307 HSGEKRHKCLECGKAFGRHSTLLCHQQIHSKPN 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	2/4 (50%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	7/20 (35%)
		C2H2 Zn finger	339..360	CDD:275368	5/20 (25%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	7/22 (32%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
ZNF789	NP_998768.2	KRAB	11..71	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<179..303	CDD:227381	39/142 (27%)
		C2H2 Zn finger	179..195	CDD:275368	4/29 (14%)
		C2H2 Zn finger	203..223	CDD:275368	7/19 (37%)
		C2H2 Zn finger	231..251	CDD:275368	7/20 (35%)
		C2H2 Zn finger	259..279	CDD:275368	5/20 (25%)
		zf-H2C2_2	271..296	CDD:290200	8/28 (29%)
		COG5048	<283..420	CDD:227381	19/60 (32%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	7/19 (37%)
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050